Recent advances and therapeutic journey of coumarins: current status and perspectives

Barot, Kuldipsinh P.; Jain, Sourabh; Kremer, Laurent; Singh, Shubhra; Ghate, Manjunath

doi:10.1007/s00044-015-1350-8

Cited by 122 publications

(72 citation statements)

References 177 publications

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“…As part of the umbelliferae family, SD contains many natural coumarins and some of the SD pyranocoumarins substitution pattern indicated for praeruptorin F, cis-3'-isovaleryl-4'-acetylkhellactone, praeruptorin B, cis-3', 4'-disenecioylkhellactone, cis-3'-isovaleryl-4'-senecioylkhellactone, (−)-cis-khellactone were at C-8/C-1'/C-3'/0/C-7, with divaricoumarins at C7 and C8 [10] . Moreover, strong synergistic interactions were also featured when pyranocoumarins were combined with common anti-tumor drugs such as vincristine, doxorubicin, and PTX [41] . These structural properties of SD engender anti-neoplastic attributes that could pose as an anti-cancer drug or an adjuvant in mainstream therapeutics with lowered cytotoxicity for chemotherapeutics.…”

Section: Discussionmentioning

confidence: 99%

Saposhnikoviae divaricata : a phytochemical, pharmacological, and pharmacokinetic review

Kreiner

Pang

Lenon

et al. 2017

Chinese Journal of Natural Medicines

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Saposhnikoviae divaricata (Turcz.) Schischk (SD) is a traditional Chinese herb commonly used to treat clinical conditions such as rheumatism and allergic rhinitis. This review article evaluates a collection of works on in vitro and biochemical studies of SD. The discourse on the diverse class of chromones and coumarins in SD offers an insight to the pharmacological effects of these bioactive constituents as anti-inflammatory, analgesic, immunoregulatory, antioxidative, and anti-proliferative agents. It is highlighted that there is a structural relationship between the constituents and bioactive activities, which in effect provides a valid reasoning and reaffirm the use of SD in the treatment of the pathologies in Chinese medicine.

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Section: Discussionmentioning

confidence: 99%

Saposhnikoviae divaricata : a phytochemical, pharmacological, and pharmacokinetic review

Kreiner

Pang

Lenon

et al. 2017

Chinese Journal of Natural Medicines

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“…). This diversity has attracted substantial attention from medicinal chemists for the development of related synthetic agents (Barot et al, 2015). Although many attempts have been made to examine novel structures for biological activities, it is increasingly important to investigate the details of the molecular mechanisms and targets to further strengthen their indication and to avoid unexpected side-effects.…”

mentioning

confidence: 99%

Seselin ameliorates inflammation via targeting Jak2 to suppress the proinflammatory phenotype of macrophages

Sun

Song

et al. 2018

British J Pharmacology

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Background and Purpose Sepsis is a serious clinical condition with a high mortality rate. Anti inflammatory agents have been found to be beneficial for the treatment of sepsis. Here, we have evaluated the anti‐inflammatory activity of seselin in models of sepsis and investigated the underlying molecular mechanism(s). Experimental Approach In vivo therapeutic effects of seselin was evaluated in two models of sepsis, caecal ligation and puncture or injection of LPS, in C57BL/6 mice. In vitro, anti‐inflammatory activity of seselin was assessed with macrophages stimulated with LPS and IFN‐γ. Anti inflammatory actions were analysed with immunohistochemical methods, ELISA and Western blotting. Flow cytometry was used to assess markers of macrophage phenotype (pro‐ or anti‐inflammatory). Other methods used included co‐immunoprecipitation, cellular thermal shift assay and molecular docking. Key Results In vivo, seselin clearly ameliorated sepsis induced by caecal ligation and puncture. In lung tissue from septic mice and in cultured macrophages, seselin down‐regulated levels of proinflammatory factors and activity of STAT1 and p65, the master signal pathway molecules for polarization of macrophages into the proinflammatory phenotype. Importantly, adoptive transfer of bone marrow‐derived macrophages, pretreated with seselin, lowered systemic proinflammatory factors in mice challenged with LPS. The underlying mechanism was that seselin targeted Jak2 to block interaction with IFNγ receptors and downstream STAT1. Conclusions and Implications Seselin exhibited anti‐inflammatory activity through its action on Jak2. These results indicated a possible application of seselin to the treatment of inflammatory disease via blocking the development of the proinflammatory phenotype of macrophages.

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“…Coumarin consists of a benzene ring attached to a pyrone ring and classified as a member of the benzopyrone family of compounds. Coumarin is the parent compound of the coumarin family, which is the large class of naturally occurring phenolic compound [8]. In this work, we designed and synthesized 7-substituted coumarin derivatives using various aromatic, and heterocyclic amines.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, anti-inflammatory, analgesic, 5-lipoxygenase (5-LOX) inhibition activities, and molecular docking study of 7-substituted coumarin derivatives

Srivastava

Vyas

Variya

et al. 2016

Bioorganic Chemistry

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Recent advances and therapeutic journey of coumarins: current status and perspectives

Cited by 122 publications

References 177 publications

Saposhnikoviae divaricata : a phytochemical, pharmacological, and pharmacokinetic review

Saposhnikoviae divaricata : a phytochemical, pharmacological, and pharmacokinetic review

Seselin ameliorates inflammation via targeting Jak2 to suppress the proinflammatory phenotype of macrophages

Synthesis, anti-inflammatory, analgesic, 5-lipoxygenase (5-LOX) inhibition activities, and molecular docking study of 7-substituted coumarin derivatives

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