Recent advances and prospects of hyaluronan as a multifunctional therapeutic system

Kotla, Niranjan G.; Bonam, Srinivasa Reddy; Rasala, Swetha; Wankar, Jitendra; Bohara, Raghvendra A.; Bayry, Jagadeesh; Rochev, Yury; Pandit, Abhay

doi:10.1016/j.jconrel.2021.07.002

Cited by 75 publications

(70 citation statements)

References 178 publications

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“…Despite this functional complexity, the medical and cosmetic use of the HA polymer is a growing industry, and in particular experimental studies predict that targeting HA synthesis, hyaluronidases, and HA receptors has enormous therapeutic potential for improving wound repair and management of cancer. For example, application of HMW–HA and its modified derivatives improve cutaneous wound repair [ 25 , 150 ]. HMW–HA is also being developed in experimental models and clinical trials to target CD44 for both imaging and delivery of therapeutics to cancer stem cells [ 145 , 151 ].…”

Section: Discussionmentioning

confidence: 99%

Hyaluronan Functions in Wound Repair That Are Captured to Fuel Breast Cancer Progression

et al. 2021

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Signaling from an actively remodeling extracellular matrix (ECM) has emerged as a critical factor in regulating both the repair of tissue injuries and the progression of diseases such as metastatic cancer. Hyaluronan (HA) is a major component of the ECM that normally functions in tissue injury to sequentially promote then suppress inflammation and fibrosis, a duality in which is featured, and regulated in, wound repair. These essential response-to-injury functions of HA in the microenvironment are hijacked by tumor cells for invasion and avoidance of immune detection. In this review, we first discuss the numerous size-dependent functions of HA and emphasize the multifunctional nature of two of its receptors (CD44 and RHAMM) in regulating the signaling duality of HA in excisional wound healing. This is followed by a discussion of how HA metabolism is de-regulated in malignant progression and how targeting HA might be used to better manage breast cancer progression.

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Section: Discussionmentioning

confidence: 99%

Hyaluronan Functions in Wound Repair That Are Captured to Fuel Breast Cancer Progression

et al. 2021

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“…In a simple approach using an octenyl succinate half-ester as reactive acylating reagent, an amphiphilic HA could be synthesized in aqueous media (Eenschooten et al, 2010). Unsaturated HA esters serve as promising building blocks for the generation of novel supramolecular hydrogel networks with potential applications in regenerative, cell-based research and therapies (Highley et al, 2016;D'Amora et al, 2019;Kotla et al, 2021).…”

Section: Esterification Reactionsmentioning

confidence: 99%

Chemical Modification of Hyaluronan and Their Biomedical Applications

2022

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Hyaluronan, the extracellular matrix glycosaminoglycan, is an important structural component of many tissues playing a critical role in a variety of biological contexts. This makes hyaluronan, which can be biotechnologically produced in large scale, an attractive starting polymer for chemical modifications. This review provides a broad overview of different synthesis strategies used for modulating the biological as well as material properties of this polysaccharide. We discuss current advances and challenges of derivatization reactions targeting the primary and secondary hydroxyl groups or carboxylic acid groups and the N-acetyl groups after deamidation. In addition, we give examples for approaches using hyaluronan as biomedical polymer matrix and consequences of chemical modifications on the interaction of hyaluronan with cells via receptor-mediated signaling. Collectively, hyaluronan derivatives play a significant role in biomedical research and applications indicating the great promise for future innovative therapies.

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“…Currently, many HA formulations are used worldwide for the treatment of pathological conditions such as bacterial acute rhinopharyngitis, eye surgery and osteoarthritis [ 117 , 118 , 119 ]. A few commercial intrarectal formulations that provide a protective barrier for intestinal epithelium are also available to promote mucosal healing and maintain gut microbial balance [ 120 ]. In a preclinical study, intracolonic administration of a combination of HA and mesalamine promoted wound healing in colonic injuries and inhibited myeloperoxidase (MPO) activity in the inflamed colon tissue of rats subjected to TNBS-induced colitis [ 121 ].…”

Section: Ha and Inflammatory Bowel Diseasementioning

confidence: 99%

Hyaluronan: A Neuroimmune Modulator in the Microbiota-Gut Axis

Bosi

Banfi

Bistoletti

et al. 2021

Cells

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The commensal microbiota plays a fundamental role in maintaining host gut homeostasis by controlling several metabolic, neuronal and immune functions. Conversely, changes in the gut microenvironment may alter the saprophytic microbial community and function, hampering the positive relationship with the host. In this bidirectional interplay between the gut microbiota and the host, hyaluronan (HA), an unbranched glycosaminoglycan component of the extracellular matrix, has a multifaceted role. HA is fundamental for bacterial metabolism and influences bacterial adhesiveness to the mucosal layer and diffusion across the epithelial barrier. In the host, HA may be produced and distributed in different cellular components within the gut microenvironment, playing a role in the modulation of immune and neuronal responses. This review covers the more recent studies highlighting the relevance of HA as a putative modulator of the communication between luminal bacteria and the host gut neuro-immune axis both in health and disease conditions, such as inflammatory bowel disease and ischemia/reperfusion injury.

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Recent advances and prospects of hyaluronan as a multifunctional therapeutic system

Cited by 75 publications

References 178 publications

Hyaluronan Functions in Wound Repair That Are Captured to Fuel Breast Cancer Progression

Hyaluronan Functions in Wound Repair That Are Captured to Fuel Breast Cancer Progression

Chemical Modification of Hyaluronan and Their Biomedical Applications

Hyaluronan: A Neuroimmune Modulator in the Microbiota-Gut Axis

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