Recent advances and progress of fluorescent bio-/chemosensors based on aggregation-induced emission molecules

Mao, Liucheng; Liu, Yanzhu; Yang, Saijiao; Li, Yongxiu; Zhang, Xiaoyong; Wei, Yen

doi:10.1016/j.dyepig.2018.10.045

Cited by 178 publications

(48 citation statements)

References 130 publications

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“…[34] Meanwhile, AIE has great potential for a myriad of applications. [35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50][51] For example, recent literature reports have explored the practical applications of AIE luminogens (AIEgens), as components of electronic devices, [52][53][54][55][56][57][58][59] chemo-/biosensors, [60][61][62][63][64][65][66] bioimaging agents, [67][68][69][70][71][72] and theranostics. [73][74][75][76][77][78] By contrasting AIE with ACQ, we can conclude that molecular-level theories and properties do not necessarily correlate with properties of aggregates.…”

Section: Introductionmentioning

confidence: 99%

Aggregate Science: From Structures to Properties

et al. 2020

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Molecular science entails the study of structures and properties of materials at the level of single molecules or small interacting complexes of molecules. Moving beyond single molecules and well‐defined complexes, aggregates (i.e., irregular clusters of many molecules) serve as a particularly useful form of materials that often display modified or wholly new properties compared to their molecular components. Some unique structures and phenomena such as polymorphic aggregates, aggregation‐induced symmetry breaking, and cluster excitons are only identified in aggregates, as a few examples of their exotic features. Here, by virtue of the flourishing research on aggregation‐induced emission, the concept of “aggregate science” is put forward to fill the gaps between molecules and aggregates. Structures and properties on the aggregate scale are also systematically summarized. The structure–property relationships established for aggregates are expected to contribute to new materials and technological development. Ultimately, aggregate science may become an interdisciplinary research field and serves as a general platform for academic research.

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Section: Introductionmentioning

confidence: 99%

Aggregate Science: From Structures to Properties

et al. 2020

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“…Finally, it is important to point out that, the aggregation of organic dyes with aggregation‐induced emission have also be used widely for biological imaging and sensing applications . In future, their applications especially in biomedical analysis should be cited.…”

Section: Resultsmentioning

confidence: 99%

Spectrophotometric study of ketoconazole binding with citrate capped silver nanoparticles and its monitoring in human plasma samples

Pashazadeh-Panahi

Hasanzadeh

Eivazzadeh‐Keihan

2020

J of Molecular Recognition

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Ketoconazole or Nizoral is an antifungal medication used to treat various type of fungal infections. It has been reported that this antifungal agent is able to induce a variety of heart function side effects, such as long‐QT syndrome, and ventricular arrhythmias. Hence, prescribing, identifying and controlling the side effects of medications such as ketoconazole is essential for human safety. In this study, a distinct and fast colorimetric probe based on citrate capped silver nanoparticles (Cit‐AgNPs) was introduced for determination of trace amounts of ketoconazole. Cit‐AgNPs were synthesized trough a novel method and applied for the quantification of ketoconazole in human plasma samples. Ultraviolet‐visible spectroscopy, transmission electron microcopy, dynamic light scattering, and energy dispersive X‐ray spectroscopy analysis, have been utilized for characterization of Cit‐AgNPs. It was revealed that in the presence of ketoconazole, the absorption intensity of Cit‐AgNPs was decreased by increasing the ketoconazole concentration. Moreover, this reaction is accompanied by a color change from shiny yellow to brown/red in acidic pH. Under acidic pH and optimum condition, the calibration graph of the assay was linear in the range of 0.1 to 0.8 μM. According to the obtained results Cit‐AgNPs can be used as a novel probe for the sensitive and specific detection and determination of similar drugs in clinical samples. Also, this method open a new way to biomedical analyses of pharmaceutical samples which is necessary in TDM.

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“…Finally, it is important to point out that, mussel-inspired chemistry is an important method for surface modification and fabrication of functional materials. [80][81][82][83][84][85][86][87][88][89][90][91][92][93][94] In future, their applications especially in biomedical analysis should be cited…”

Section: Short-term Stability Of Dpa-gqdsmentioning

confidence: 99%

A novel optical probe based on d‐penicillamine‐functionalized graphene quantum dots: Preparation and application as signal amplification element to minoring of ions in human biofluid

Pashazadeh-Panahi

Hasanzadeh

Eivazzadeh‐Keihan

2020

J of Molecular Recognition

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In this study, d‐penicillamine‐functionalized graphene quantum dots (DPA‐GQD) has been synthesized, which significantly increases the fluorescence intensity of GQD. We used this simple fluorescent probe for metal ions detection in human plasma samples. Designed DPA‐GQD respond to Hg2+, Cu2+, Au2+, Ag+, Co2+, Zn2+, and Pb2+ with high sensitivity. The fluorescence intensity of this probe decreased significantly in the presence of metal ions such as, Hg2+, Cu2+, Au2+, Ag+, Co2+, Zn2+, and Pb2+. In this work, a promising probe for ions monitoring was introduced. Moreover, DPA‐GQD probe has been tested in plasma samples. The functionalized DPA‐GQDs exhibits great promise as an alternative to previous fluorescent probes for bio‐labeling, sensing, and other biomedical applications in aqueous solution.

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Recent advances and progress of fluorescent bio-/chemosensors based on aggregation-induced emission molecules

Cited by 178 publications

References 130 publications

Aggregate Science: From Structures to Properties

Aggregate Science: From Structures to Properties

Spectrophotometric study of ketoconazole binding with citrate capped silver nanoparticles and its monitoring in human plasma samples

A novel optical probe based on d‐penicillamine‐functionalized graphene quantum dots: Preparation and application as signal amplification element to minoring of ions in human biofluid

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