Following sustainable development, companies and researchers of the packaging area are developing biodegradable materials from renewable resources. This work proposed the production of biodegradable cassava starch films by extrusion, evaluating different additives: glycerol and water as plasticizers, acids as chemical modifiers and microfibrillated cellulose (CMF) as reinforcer. The films were evaluated by their mechanical properties (thickness, tensile strength, percentage of elongation at break and Young's modulus), and surface (moisture, solubility, contact angle, color difference and opacity). It was obtained films with diversified and promising characteristics. From the obtained results the optimal film was chosen, that is, with the best properties for application as food packaging. After that, films were elaborated with anthocyanin for potential use as smart package. Beyond the characterization already described for films produced in the first step of this work, morphology and crystallinity were also evaluated. pH indicator activity was verified for two kinds of meat (beef and fish), at three different concentrations of anthocyanin (5, 10 and 20) mg of anthocyanin/100 g of film, at two different storage conditions (ambient and under refrigeration). By the color change measurement of the film, it was possible to correlate the pH change of the foods tested. The obtained results were promising, since the films performed as good pH indicators, as the color changes was noticeable to the naked eye, and this change was more pronounced in films with lower anthocyanin content.