2020
DOI: 10.3390/pharmaceutics12121156
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Recent Advances and Challenges in Controlling the Spatiotemporal Release of Combinatorial Anticancer Drugs from Nanoparticles

Abstract: To overcome cancer, various chemotherapeutic studies are in progress; among these, studies on nano-formulated combinatorial drugs (NFCDs) are being actively pursued. NFCDs function via a fusion technology that includes a drug delivery system using nanoparticles as a carrier and a combinatorial drug therapy using two or more drugs. It not only includes the advantages of these two technologies, such as ensuring stability of drugs, selectively transporting drugs to cancer cells, and synergistic effects of two or … Show more

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Cited by 23 publications
(21 citation statements)
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“…Overall, polymer nanoparticles are a promising platform for co-delivery of drug combinations for ovarian cancer treatment. Advances in nanoparticle design can improve drug delivery by addressing drug resistance [ 4 , 28 , 30 , 31 , 69 , 71 ]. Specifically, sequential combination therapy with free drug formulations has been shown to improve drug efficacy and overcome resistance mechanisms.…”
Section: Discussionmentioning
confidence: 99%
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“…Overall, polymer nanoparticles are a promising platform for co-delivery of drug combinations for ovarian cancer treatment. Advances in nanoparticle design can improve drug delivery by addressing drug resistance [ 4 , 28 , 30 , 31 , 69 , 71 ]. Specifically, sequential combination therapy with free drug formulations has been shown to improve drug efficacy and overcome resistance mechanisms.…”
Section: Discussionmentioning
confidence: 99%
“…Incorporation of the drugs into nanoparticles can improve the solubility and reduce toxicity [ 18 , 69 ]. Controlled drug release from nanoparticles could facilitate sequential drug delivery to facilitate improved control of the pharmacokinetics [ 30 , 31 , 70 ]. Thus, we review polymer-based nanoparticles (micelles, dendrimers, and solid lipid polymer-based platforms ( Figure 4 )) for simultaneous and sequential delivery of platinum- or taxane-based combinations applied to ovarian cancer with an emphasis on quantitative evaluation of nanoparticle formulation on drug synergy.…”
Section: Nanoparticle Formulation Of Drug Combinationsmentioning
confidence: 99%
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