Advances in nano‐preparations for improving tetrandrine solubility and bioavailability
Jie Ling,
Jingping Wu,
Yuening Cao
et al.
Abstract:Tetrandrine (TET) is a natural bis‐benzylisoquinoline alkaloid isolated from Stephania species with a wide range of biological and pharmacologic activities; it mainly serves as an anti‐inflammatory agent or antitumor adjuvant in clinical applications. However, limitations such as prominent hydrophobicity, severe off‐target toxicity, and low absorption result in suboptimal therapeutic outcomes preventing its widespread adoption. Nanoparticles have proven to be efficient devices for targeted drug delivery since … Show more
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