Recent Advancements in Triazole-based Click Chemistry in Cancer Drug Discovery and Development

Ak, Yadav; Mishra, Vivek; Kumar, Deepak; Kumar, Arun

doi:10.1055/s-0042-1751452

Cited by 13 publications

(1 citation statement)

References 116 publications

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“…It requires only a light click to accomplish a conversion rate close to 100% . The “Click” is fast, gentle, thorough, and even unassisted; thus, it is utilized in many fields such as material preparation, bioimaging, and chemical synthesis . Motivated by the strengths of click chemistry, the efficient connectivity properties of clicks are employed in the sensing field to pioneer novel and superior technologies.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous Detection of Micro-RNAs by a Disposable Biosensor via the Click Chemistry Connection Strategy

Liu,

Wang,

et al. 2024

Anal. Chem.

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Section: Introductionmentioning

confidence: 99%

Simultaneous Detection of Micro-RNAs by a Disposable Biosensor via the Click Chemistry Connection Strategy

Liu,

Wang,

et al. 2024

Anal. Chem.

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Novel tetrahydropyran‐triazole hybrids with antiproliferative activity against human tumor cells

Quintana,

González‐Bakker,

Khan

et al. 2024

Archiv der Pharmazie

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A series of new hybrid compounds was prepared combining tetrahydropyran rings with different aromatic systems by means of a 1,2,3‐triazole, using a building block strategy. The design of these structures was guided by Lead‐Likeness and Molecular Analysis (LLAMA) software, adding modifications to our most potent scaffold (the tetrahydropyran ring) to generate promising “lead‐like” candidates, which were subsequently compared against reported anticancer compounds. Our synthesized compounds demonstrated significant antiproliferative activity when compared with the standards cisplatin and 5‐fluorouracil, across a panel of six different tumor cell lines. Moreover, compared with our group's previous hybrid compounds, these new structures exhibit similar activity while offering simpler synthesis and greater potential for structural diversification, a fact that was previously an issue. Further investigations on the most active compounds included assessments of reproductive cell survival, inhibition of cell migration, and effects on nuclear morphology, indicating potential diverse mechanisms of action for these compounds. Pharmacokinetic properties were also calculated for the whole series of compounds using the pkCSM online software.

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Recent advancement of HDAC inhibitors against breast cancer

et al. 2023

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Recent Advancements in Triazole-based Click Chemistry in Cancer Drug Discovery and Development

Abstract: Triazole-based compounds possess a broad range of activity and can be synthesized using click chemistry. Many new chemotherapeutic agents have been developed in recent years by exploiting click chemistry and these are covered in this review.

Cited by 13 publications

References 116 publications

Simultaneous Detection of Micro-RNAs by a Disposable Biosensor via the Click Chemistry Connection Strategy

Simultaneous Detection of Micro-RNAs by a Disposable Biosensor via the Click Chemistry Connection Strategy

Novel tetrahydropyran‐triazole hybrids with antiproliferative activity against human tumor cells

Recent advancement of HDAC inhibitors against breast cancer

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