Recent Advancements in Prognostic Factors of Epithelial Ovarian Carcinoma

Abstract

Ovarian cancer remains the most common cause of gynecologic cancer-related death among women in developed countries. Nevertheless, subgroups of ovarian cancer patients experience relatively longer survival. Efforts to identify prognostic factors that characterize such patients are ongoing, with investigational areas including tumor characteristics, surgical management, inheritance patterns, immunologic factors, and genomic patterns. This review discusses various demographic, clinical, and molecular factors implicating longevity and ovarian cancer survival. Continued efforts at identifying these prognosticators may result in invaluable adjuncts to the treatment of ovarian cancer, with the ultimate goal of advancing patient care.

Patient inflammatory status and CD4+/CD8+ intraepithelial tumor lymphocyte infiltration are predictors of outcomes in high-grade serous ovarian cancer

“…Among these, high-grade serous ovarian cancers (HGSOCs) are the most prevalent representing 80-85% and display the highest mortality rates [2]. Several prognostic factors have been proposed for HGSOC, including: stage, quality of debulking surgery, and response to chemotherapy [3,4], however only a few of them have been demonstrated clinically relevant [5].…”

Perbedaan Kadar Interferon Gamma Cairan Asites Pada Subtipe Histopatologi Serosa dan Non-Serosa Kanker Ovarium Tipe Epitel

“…Kanker ovarium paling banyak adalah tipe epitel, dimana 70% pasien datang sudah dalam stadium lanjut, dengan angka ketahanan hidup 10 tahun sekitar 15-30%; sedangkan angka ketahanan hidup untuk stadium awal adalah lebih dari 90%. 4 Kanker ovarium tipe epitel merupakan penyakit heterogen dengan berbagai subtipe histologi (histotipe) yang berbeda dalam asal sel, patogenesis, perubahan molekuler, ekspresi gen, dan prognosis. Secara histologis, WHO mengklasifikasikan tumor ovarium tipe epitel menjadi tipe serosa, musinosa, endometrioid, clear cell, seromusin, brenner dan karsinoma yang tidak terdiferensiasi.…”

Ovarian carcinoma: An overview of current status

“…In a recent study, different factors found associated with the prognosis of EOC include patient's age, performance status, tumor stage and ascites, tumor grade, histopathologic subtype, obesity, surgical de-bulking, expression of genes (CYP4B1, CEPT1, CHMP4A), and immunological factors [21] .…”

“…Antibody therapy, immune checkpoint inhibitors, vaccine strategies, adoptive cell therapy, and combinatorial immunotherapy are all used for the treatment of the disease [16] . There are numerous review papers discussing ovarian carcinoma's origin and its development [17] , types and subtypes [13,18] , diagnosis [19,20] , prognosis [21] , and treatment [16,[22][23][24] . As such, there is a need to review and update existing information on ovarian carcinoma.…”