2018
DOI: 10.2174/1871520617666171106125114
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Recent Advancements in Organotin(IV) Complexes as Potential Anticancer Agents

Abstract: Cancer is a multistep disease incorporating physical, chemical, environmental, metabolic and genetic factors, which play direct or indirect role in the induction and deterioration of cancer. Many of the platinum based drugs were synthesized but due to their systemic toxicity, broad spectrum of action, intrinsic and acquired drug resistivity, it has become necessary to search for the effective anticancer drugs with superior efficiency. Among non-platinum metal compounds with antitumor activity, organotin comple… Show more

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Cited by 61 publications
(54 citation statements)
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“…The coloured Schiff base products that precipitated out on refluxing were filtered and recrystallized from cold methanol and chloroform to afford the pure products. (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20) Transition metal complexes of Co(II), Ni(II), Cu(II) and Zn(II) ions were prepared by reacting a hot methanolic solution (20 ml) of synthesized Schiff base (2 mmol) with a methanolic solution (10 ml) of metal acetate (1 mmol) with vigorous stirring for 2-3 h in a molar ratio of 2:1 at room temperature by adjusting the pH between 4 and 5 (Scheme 2). The different coloured solid complexes that precipitated out were filtered, washed with hot methanol and finally dried in hexane to afford the pure complexes.…”
Section: Synthesis Of Schiff Base Ligands (Hl 1 -Hl 4 )mentioning
confidence: 99%
See 1 more Smart Citation
“…The coloured Schiff base products that precipitated out on refluxing were filtered and recrystallized from cold methanol and chloroform to afford the pure products. (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20) Transition metal complexes of Co(II), Ni(II), Cu(II) and Zn(II) ions were prepared by reacting a hot methanolic solution (20 ml) of synthesized Schiff base (2 mmol) with a methanolic solution (10 ml) of metal acetate (1 mmol) with vigorous stirring for 2-3 h in a molar ratio of 2:1 at room temperature by adjusting the pH between 4 and 5 (Scheme 2). The different coloured solid complexes that precipitated out were filtered, washed with hot methanol and finally dried in hexane to afford the pure complexes.…”
Section: Synthesis Of Schiff Base Ligands (Hl 1 -Hl 4 )mentioning
confidence: 99%
“…So, transition metals of the late first row, cobalt, nickel, copper and zinc, which are biologically applicable metals as they are associated with various biomolecules related to essential physiological activities, have been used for synthesis of complexes. Furthermore, a large number of transition metal complexes derived from salicylaldehyde derivatives have been prepared and tested in the past as possible antitumour agents and many of them exhibited interesting activity in specific cancer models.…”
Section: Introductionmentioning
confidence: 99%
“…An extensive research interest in the rich coordination chemistry of organotin complexes has been not only due to that tin exhibits a variety of coordination numbers and geometries [1,2] but also because of their wide industrial (antifouling paints, wood preservatives and Metallo-pharmaceuticals) [3,4] and valuable biocidal applications (anti-inflammatory anti-hypertensive, anti-hyperbilirubin, antiviral, antiparasitic, antioxidant, antibiotic, cytotoxicity, antiproliferative and antimicrobial). [5][6][7][8][9][10][11][12][13][14] Hence there is a growing need to synthesize new classes of organotin compounds and to study their bioactivityhigh activity and low toxicity in particular.…”
Section: Introductionmentioning
confidence: 99%
“…[3,4] In this context, the coordination chemistry of organotin(IV) and organosilicon(IV) complexes of Schiff bases derived from various heterocycles has been reported to possess versatile bio activities e. g. anticonvulsant, antiproliferative, anticancer, antimicrobial, anticarcinogenic, tuberculostatic, anti-HIV, antifertility, anti inflammatory and antimalarial activities. [5][6][7][8][9][10][11][12][13][14] They are also reported to act as insecticidal, acaricidal, nematicidal and herbicidal agents. In addition, Schiff base organotin(IV) and organosilicon(IV) complexes were of great interest for structural reasons as they offer a great variety of molecular architectures, leading to diverged coordination modes.…”
Section: Introductionmentioning
confidence: 99%