Recent advancements in electrospinning design for tissue engineering applications: A review

Abstract

Electrospinning, a technique used to fabricate fibrous scaffolds, has gained popularity in recent years as a method to produce tissue engineered grafts with architectural similarities to the extracellular matrix. Beyond its versatility in material selection, electrospinning also provides many tools to tune the fiber morphology and scaffold geometry. Recent efforts have focused on extending the capabilities of electrospinning to produce scaffolds that better recapitulate tissue properties and enhance regeneration. This review highlights these advancements by providing an overview of the processing variables and setups used to modulate scaffold architecture, discussing strategies to improve cellular infiltration and guide cell behavior, and providing a summary of electrospinning applications in tissue engineering. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 2892-2905, 2017.

Target regulation of both VECs and VSMCs by dual‐loading miRNA‐126 and miRNA‐145 in the bilayered electrospun membrane for small‐diameter vascular regeneration

“…Electrospinning is a unique technique to prepare nano‐ or micro‐structured membranes, and has been widely used to fabricate vascular grafts . Electrospun fibrous membranes can also efficiently load bioactive agents and drugs for regulation of cellular physiological functions . However, ultrafine fibrous membranes may exhibit limitations by improving cell adhesion rather than cellular infiltration, whereas electrospun fibers in micron‐size can be of great benefit to cell ingrowth .…”

“…[1][2][3] Electrospun fibrous membranes can also efficiently load bioactive agents and drugs for regulation of cellular physiological functions. 10,11 However, ultrafine fibrous membranes may exhibit limitations by improving cell adhesion rather than cellular infiltration, whereas electrospun fibers in micron-size can be of great benefit to cell ingrowth. [12][13][14][15] Therefore, double or multiple-layered electrospun membranes with different fiber diameters can fulfill various functions to facilitate rapid and complex tissue recovery.…”

Recent studies on electrospinning preparation of patterned, core–shell, and aligned scaffolds

“…[43][44][45] The effect of process variables and material diversity on fiber has been well documented. [46][47][48][49] In this review, we provide an in-depth focus on electrospinning underlining techniques to produce fibers for biological morphology and application. Herein, we discuss the basic working principles and compare several additional features electrostatic lens auxiliary electrode, core-shell, the core structure of the spray nozzle and a needle core induction receiver.…”

Electrospun polymer blend with tunable structure for oil–water separation

“…Among various techniques for preparation of membranes, electrospinning (ES) has attracted considerable attention. Electrospun nanofibrous membranes can be engineered to have interconnected porous structure with large surface area to volume ratio which makes them good candidates for several applications such as filtration, waterproof clothing, drug delivery, and tissue engineering …”