Recent advance: Sulfur ylides in organic synthesis

Abstract

Sulfur ylides are versatile structures that display various characteristics and participate in a myriad of reactions to produce simple, effective, and sometimes stereoselective reactions toward synthesizing sulfur‐containing compounds. Nonetheless, their fulfillment tremendous developments have been made in this field in the past few decades. In this comprehensive review, luminosity is illuminated on the application of sulfur ylides involved in various domino, cascade annulation reactions, and carbene trapping reagents with chameleonic reactivity. In the past numerous decennary, chemists have used sulfur ylides in solvent‐dependent, rhodium catalyzed, dealkylative intercepted, photochemical reaction, halotrifluoromethylation, benzannulation, amidation various name reactions such as Mizoroki–Heck, Suzuki–Miyaura, and Sommelet–Hauser rearrangements. Moreover, other prime applications include metal catalysis, epoxidation of carbonyl compounds, acylmethylation, cyclomerization, oxidation, and insertion reactions. Additionally, some sulfur ylides are extremely useful structures that play a major role in the synthesis of various medicinally active heterocycles structural motifs. This review article discusses all these reactions, their proposed mechanisms, and their application in the current scenario, at length. This tutorial review concludes by providing a future outlook on the investigation into sulfur ylides and various other compounds synthesized using it have great potential to be used in industries, laboratories, pharmaceutical companies, drug production, clinical use, medicinal chemistry, and agrochemical purposes.

Solvent-involved synthesis of pyrrolidin-5-one-2-carboxamides via a sequential Ugi/olefination reaction

“…On the basis of the results obtained and the related literature, 15 a plausible reaction mechanism for the Ugi/olefination reaction is proposed, as depicted in Scheme 3. The Ugi adducts A could be converted into sulfur ylides B with the help of K 2 CO 3 .…”