Recapsoma®: A Novel Mixture Based on Bergamot, Ipomoea Batatas, Policosanol Extracts and Liposomal Berberine for the Treatment of Hypercholesterolemia

Amante, Chiara; Esposito, Tiziana; Luccheo, Gianni; Luccheo, Luigi; Russo, Paola; Gaudio, Pasquale Del

doi:10.3390/life12081162

Cited by 4 publications

(4 citation statements)

References 44 publications

(44 reference statements)

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“…Lipid nanoparticles are bioactive carrier systems that can improve transport, pharmacokinetics, and stability of encapsulated nutraceuticals; nanoemulsions and microemulsions have also been employed [46]. These formulations have been utilized to deliver nutraceuticals for the treatment of hypercholesterolemia in adult subjects, such as polyphenols and bergamot [47]. Some, but not all, guidelines for dyslipidemia include nutraceuticals among potentially effective treatment options for mild dyslipidemia.…”

Section: Nutraceuticals In the Treatment Of Familial Hypercholesterol...mentioning

confidence: 99%

Diet and Lipid-Lowering Nutraceuticals in Pediatric Patients with Familial Hypercholesterolemia

Capra,

Biasucci,

Banderali

et al. 2024

Children

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Familial hypercholesterolemia is a genetically determined disease characterized by elevated plasma total and LDL cholesterol levels from the very first years of life, leading to early atherosclerosis. Nutritional intervention is the first-line treatment, complemented with nutraceuticals and drug therapy when necessary. Nutraceuticals with a lipid-lowering effect have been extensively studied in the past few decades, and have been recently included in international guidelines as a complement to nutritional and pharmacological treatment in subjects with dyslipidemia. In this review, we explore current nutritional interventions for dyslipidemia in childhood, with a specific focus on the main nutraceuticals studied for treating severe dyslipidemia in pediatric patients. Additionally, we briefly describe their primary mechanisms of action and highlight the advantages and risks associated with the use of lipid-lowering nutraceuticals in childhood.

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Section: Nutraceuticals In the Treatment Of Familial Hypercholesterol...mentioning

confidence: 99%

Diet and Lipid-Lowering Nutraceuticals in Pediatric Patients with Familial Hypercholesterolemia

Capra,

Biasucci,

Banderali

et al. 2024

Children

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“…It contains abundant nutrients, including protein, carbohydrates, minerals, vitamins, carotenoids, dietary fber, and polyphenols. Previous studies have reported that sweet potato has many benefcial efects such as antioxidation [5][6][7], anticancer [8,9], anti-infammatory [10], liver protection [11], and prevention of cardiovascular disease [12]. Owing to its nutritional components and agronomic advantages, sweet potato could help prevent and reduce mal-or overnutrition in developing and developed countries.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Nutrients and Antioxidant Activities in Sweet Potatoes

Xi-You,

Rong-Jiao,

Xin-Yu

et al. 2024

Journal of Food Biochemistry

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Sweet potato has played an important role in human diets for centuries. Sweet potato is an excellent source of nutrients and natural health-promoting chemicals such as carotenoids, vitamin C, and polyphenols. In this article, we selected forty-eight sweet potato cultivars to evaluate the contents of proximate compositions, phytochemicals, and total antioxidative capacity (TAC). In addition, the sensory taste test was conducted as well. The concentrations of chemical constituents varied significantly among the 48 cultivars. The starch content ranged from 10.58% to 28.08%. The protein concentration was between 2.00% and 12.16%. A noticeable variability was found in vitamin C (8.17–66.09 mg·100 g−1), total polyphenols (0.32–13.82 µg·g−1), and carotenoids (0.22–559.70 µg·g−1). 3,5-dicaffeoylquinic acid was the dominant phenolic acid derivative in all varieties, followed by chlorogenic acid. The content ranges of 3,5-dicaffeoylquinic acid and chlorogenic acid were 0.41–92.18 µg·100 g−1 and 1.59–63.98 µg·100 g−1, respectively. Remarkable DPPH (0.19–0.59 µg·g−1) and ABTS+ (0.19–1.42 µg·g−1) antioxidant activities were also observed in these sweet potatoes. TAC was related to vitamin C, carotenoids, total polyphenols, and caffeic acid derivatives. The purple flesh cultivars, especially Mianzishu-9, Jiheishu-1, and Qianshu-18-5-1, rich in protein, starch, and antioxidants, had immense potential to improve malnutrition and hidden hunger. The dark orange flesh cultivars Hongxiangjiao and Ziyunhongxinshu performed best in sensory taste evaluation, but the nutrients and antioxidant effects were ordinary. These cultivars were suitable for enriching the human food systems.

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“…According to the World Health Organization (WHO), cardiovascular diseases (CVDs) are the leading cause of mortality, both in industrialized and developing countries [ 1 ]. In 2019, around 17.9 million people died from CVDs, representing 32% of deaths world-wide.…”

Section: Introductionmentioning

confidence: 99%

“…In 2019, around 17.9 million people died from CVDs, representing 32% of deaths world-wide. By 2030, it is estimated that at least 24 million people may die mainly from heart attack or stroke [ 1 , 2 ].…”

Section: Introductionmentioning

confidence: 99%

Anti-Hypercholesterolemia Effects of Edible Seaweed Extracts and Metabolomic Changes in Hep-G2 and Caco-2 Cell Lines

Coelho

Pacheco

2023

Life

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Hypercholesterolemia is a major risk for the development of cardiovascular diseases (CVDs), the main cause of mortality worldwide, and it is characterized by high levels of circulating cholesterol. The drugs currently available for hypercholesterolemia control have several side effects, so it is necessary to develop new effective and safer therapies. Seaweeds serve as sources of several bioactive compounds with claimed beneficial effects. Eisenia bicyclis (Aramé) and Porphyra tenera (Nori) are edible seaweeds that were previously recognized as rich in bioactive compounds. In the present study, we aim to evaluate the anti-hypercholesterolemia effect of these two seaweed extracts and their health potential. Both extracts, but more efficiently Aramé extract, have liver 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) inhibitory activity as well as the capability to reduce approximately 30% of cholesterol permeation through human Caco-2 cells by simulating the intestinal lining, which is a target for hypercholesterolemia treatments. An untargeted metabolomic assay on human intestinal Caco-2 and liver Hep-G2 cell lines exposed to Aramé and Nori extracts revealed changes in the cells’ metabolism, indicating the extracts’ health beneficial effects. The metabolic pathways affected by exposure to both extracts were associated with lipid metabolism, such as phospholipids, and fatty acid metabolism, amino acid pathways, cofactors, vitamins, and cellular respiration metabolism. The effects were more profound in Aramé-treated cells, but they were also observed in Nori-exposed cells. The metabolite modifications were associated with the protection against CVDs and other diseases and to the improvement of the cells’ oxidative stress tolerance. The results obtained for the anti-hypercholesterolemia properties, in addition to the revelation of the positive impact on cell metabolism, offer an important contribution for further evaluation of these seaweed extracts as functional foods or for CVD prevention.

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Recapsoma®: A Novel Mixture Based on Bergamot, Ipomoea Batatas, Policosanol Extracts and Liposomal Berberine for the Treatment of Hypercholesterolemia

Cited by 4 publications

References 44 publications

Diet and Lipid-Lowering Nutraceuticals in Pediatric Patients with Familial Hypercholesterolemia

Diet and Lipid-Lowering Nutraceuticals in Pediatric Patients with Familial Hypercholesterolemia

Comparison of Nutrients and Antioxidant Activities in Sweet Potatoes

Anti-Hypercholesterolemia Effects of Edible Seaweed Extracts and Metabolomic Changes in Hep-G2 and Caco-2 Cell Lines

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