Rebamipide liposome as an effective ocular delivery system for the management of dry eye disease

Qiao, Han; Wang, Chao; Sun, Mengchi; Fu, Shuwen; Zhao, Fangxue; Wang, Danping; Zhang, He; Zhai, Yinglei; Sun, Jun

doi:10.1016/j.jddst.2022.103654

Cited by 14 publications

(11 citation statements)

References 22 publications

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“…Table 1 shows that there is a slight increase in the hydrodynamic diameter of the transfersomes during storage (no more than 6%). According to the literature data, liposomal systems are characterized by a slight increase in size and polydispersity index during storage [ 37 , 38 , 39 , 40 ]. It is worth noting that changes in size in most cases were insignificant; however, it is mentioned that fresh liposomes show greater efficiency than liposomes stored for a long time [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

Transdermal Delivery of 2-PAM as a Tool to Increase the Effectiveness of Traditional Treatment of Organophosphate Poisoning

Васильева

Gaynanova

Zueva

et al. 2022

IJMS

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For the first time, the efficacy of post-exposure treatment of organophosphate (OP) poisoning was increased by transdermal delivery of acetylcholinesterase (AChE) reactivator pyridine-2-aldoxime methochloride (2-PAM) as a preventive countermeasure. By selecting the optimal ratio of components, classical transfersomes (based on soybean phosphatidylcholine and Tween 20) and modified transfersomes (based on soybean phosphatidylcholine, Tween 20 and pyrrolidinium cationic surfactants with different hydrocarbon tail lengths) were obtained for 2-PAM encapsulation. Transfersomes modified with tetradecylpyrrolidinium bromide showed the best results in encapsulation efficiency and sustained release of 2-PAM from vesicles. Using Franz cells, it was found that the incorporation of surfactants into PC liposomes results in a more prolonged release of 2-PAM through the rat skin. Transfersomes containing 2-PAM, after exhaustive physical and chemical characterization, were embedded in a gel based on Carbopol® 940. A significantly high degree of erythrocyte AChE reactivation (23 ± 7%) was shown for 2-PAM in unmodified transfersomes in vivo. Preliminary transdermal administration of 2-PAM 24 h before emergency post-exposure treatment of OP poisoning leads to an increase in the survival rate of rats from 55% to 90%.

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Section: Discussionmentioning

confidence: 99%

Transdermal Delivery of 2-PAM as a Tool to Increase the Effectiveness of Traditional Treatment of Organophosphate Poisoning

Васильева

Gaynanova

Zueva

et al. 2022

IJMS

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“…They exhibited an equivalent therapeutic effect observed by fluorescein staining compared to the commercially available rebamipide formulation which was several times more concentrated than the nanoliposomes. The nanoliposomes improved drug retention and allowed for sufficient drug concentration at the cornea and aqueous humor, reducing the frequency of administration and the adverse effects [ 152 ].…”

Section: Nano-based Dds For Anterior Segment Diseasesmentioning

confidence: 99%

Breaking Barriers in Eye Treatment: Polymeric Nano-Based Drug-Delivery System for Anterior Segment Diseases and Glaucoma

Ashkar

Jain

et al. 2023

Polymers

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The eye has anatomical structures that function as robust static and dynamic barriers, limiting the penetration, residence time, and bioavailability of medications administered topically. The development of polymeric nano-based drug-delivery systems (DDS) could be the solution to these challenges: it can pass through ocular barriers, offering higher bioavailability of administered drugs to targeted tissues that are otherwise inaccessible; it can stay in ocular tissues for longer periods of time, requiring fewer drug administrations; and it can be made up of polymers that are biodegradable and nano-sized, minimizing the undesirable effects of the administered molecules. Therefore, therapeutic innovations in polymeric nano-based DDS have been widely explored for ophthalmic drug-delivery applications. In this review, we will give a comprehensive overview of polymeric nano-based drug-delivery systems (DDS) used in the treatment of ocular diseases. We will then examine the current therapeutic challenges of various ocular diseases and analyze how different types of biopolymers can potentially enhance our therapeutic options. A literature review of the preclinical and clinical studies published between 2017 and 2022 was conducted. Thanks to the advances in polymer science, the ocular DDS has rapidly evolved, showing great promise to help clinicians better manage patients.

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“…Utilizing eye drops containing Rebamipide loaded liposomes showed better stability, controlled release rate, and better tolerance by the patients. Application via liposomes could improve the bioavailability of the drug in the cornea, enhance its effectiveness, and reduce the dosage and irritation effects [ 34 ].…”

Section: Topical Nano-formulations For Ocular Drug Deliverymentioning

confidence: 99%

Application of Convergent Science and Technology toward Ocular Disease Treatment

et al. 2023

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Eyes are one of the main critical organs of the body that provide our brain with the most information about the surrounding environment. Disturbance in the activity of this informational organ, resulting from different ocular diseases, could affect the quality of life, so finding appropriate methods for treating ocular disease has attracted lots of attention. This is especially due to the ineffectiveness of the conventional therapeutic method to deliver drugs into the interior parts of the eye, and the also presence of barriers such as tear film, blood-ocular, and blood-retina barriers. Recently, some novel techniques, such as different types of contact lenses, micro and nanoneedles and in situ gels, have been introduced which can overcome the previously mentioned barriers. These novel techniques could enhance the bioavailability of therapeutic components inside the eyes, deliver them to the posterior side of the eyes, release them in a controlled manner, and reduce the side effects of previous methods (such as eye drops). Accordingly, this review paper aims to summarize some of the evidence on the effectiveness of these new techniques for treating ocular disease, their preclinical and clinical progression, current limitations, and future perspectives.

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Rebamipide liposome as an effective ocular delivery system for the management of dry eye disease

Cited by 14 publications

References 22 publications

Transdermal Delivery of 2-PAM as a Tool to Increase the Effectiveness of Traditional Treatment of Organophosphate Poisoning

Transdermal Delivery of 2-PAM as a Tool to Increase the Effectiveness of Traditional Treatment of Organophosphate Poisoning

Breaking Barriers in Eye Treatment: Polymeric Nano-Based Drug-Delivery System for Anterior Segment Diseases and Glaucoma

Application of Convergent Science and Technology toward Ocular Disease Treatment

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