Rearrangements and stereochemistry of sulfur additions to olefins

Reaction of quadricyclane with fluorinated sulfur-containing compounds

“…Only 3,4,5-trithiatricyclo[5.2.1.0 2,6 ]non-8-ene (32% yield) was formed as a result of the sulfur reaction with NBD [19,20]. In sharp contrast to NBD, 2 does not react with sulfur in DMF solvent (70 8C, 5 h, see Section 3.1).…”

“…The reaction mixture was agitated overnight at ambient temperature, diluted with 10% HCl (600 mL), extracted with CH 2 Cl 2 (50 mL Â 3). The extract was washed with 10% HCl (300 mL Â 2), dried over MgSO 4 , solvent was removed under vacuum and the residue was distilled under reduced pressure to give 20 g (32%) of 3,4,5-trithiatricyclo[5.2.1.0 2,6 ]non-8-ene [19,20], b.p. 68-70/ 15 mmHg, purity 98% purity.…”

Hetero-Diels-Alder and Cheletropic Additions of Sulfur Dioxide to 1,2-Dimethylidenecycloalkanes. Determination of Thermochemical and Kinetics Parameters for Reactions in Solution and Comparison with Estimates From Quantum Calculations

“…1 (3)); 3.88 (d, 2 J 13.7, H b ÀC(3)); 2.79 (ddd, 2 J 11.8, 3 J 11.8, J 3.7, H a ÀC (5) or H a ÀC(7)); 2.68 (ddd, 2 J 16.5, 3 J 6.5, J 4.0, H a ÀC (7) or H a ÀC(5)); 2.45 (ddd, 2 J 16.5, 3 J 10.5, J 3.7, H b ÀC(5) or H b ÀC(7)); 2.27 (ddd, 2 J 11.8, 3 J 5.9, J 4.0, H b ÀC(7) or H b ÀC(5)); 2.19 (m, H a ÀC(6)); 2.01 (m, H b ÀC (6)). The yellow soln.…”

Synthesis, Characterization, and Biological Activity Studies of Copper(II) Mixed Compound with Histamine and Nalidixic Acid

“…Also, it is suggested that quinolone may form coordination complexes with a transition metal ion present in the cytoplasm or with a metal biocomplex; this metal ion could be copper(II) [ 12 ]. Copper in biological systems is usually found surrounded by imidazole moieties from histidine residues [ 13 , 14 ]. Copper concentration increases when a disease like arthritis or a neoplasia is present; therefore under the stress caused by the disease, copper may be available for coordination with some endogenic or exogenic compounds like peptides and drugs, respectively.…”