Rearing and Caring for a Future Xenograft Donor Pig

Hansen, Axel Kornerup; Dahl, Kirsten; Sørensen, Dorte Bratbo

doi:10.1186/1751-0147-45-s1-s45

Cited by 2 publications

(2 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To reduce psychological and physiological stress that can be transmitted to organs, transgenic pigs will have stimulation, including toys and possibly conspecifics. 46 They will not be slaughtered in massive slaughtering factories that increase stress and pain; rather, in order to ensure the safe retrieval of organs, transgenic pigs will be as painlessly sedated as possible. In other words, there is a compelling reason inherent in xenotransplantation research itself to treat transgenic pigs as well as possible and to minimize pain.…”

Section: Transgenic Pigs Must Have Lives Worth Livingmentioning

confidence: 99%

“…In order to maximize the health of the transplantable organs and minimize zoonotic concerns, transgenic pigs will not be housed in cramped, miserable cages, nor will they live in their own waste as is often the case on industrialized farms. To reduce psychological and physiological stress that can be transmitted to organs, transgenic pigs will have stimulation, including toys and possibly conspecifics 46 . They will not be slaughtered in massive slaughtering factories that increase stress and pain; rather, in order to ensure the safe retrieval of organs, transgenic pigs will be as painlessly sedated as possible.…”

Section: Transgenic Pigs Must Have Lives Worth Livingmentioning

confidence: 99%

See 1 more Smart Citation

In defense of xenotransplantation research: Because of, not in spite of, animal welfare concerns

Bobier

Cooper

Hurst

et al. 2022

Xenotransplantation

View full text Add to dashboard Cite

It is envisioned that one day xenotransplantation will bring about a future where transplantable organs can be safely and efficiently grown in transgenic pigs to help meet the global organ shortage. While recent advances have brought this future closer, worries remain about whether it will be beneficial overall. The unique challenges and risks posed to humans that arise from transplanting across the species barrier, in addition to the costs borne by non-human animals, has led some to question the value of xenotransplantation altogether. In response, we defend the value of xenotransplantation research, because it can satisfy stringent welfare conditions on the permissibility of animal research and use. Along the way, we respond to the alleged concerns, and conclude that they do not currently warrant a cessation or a curtailing of xenotransplantation research.

show abstract

Section: Transgenic Pigs Must Have Lives Worth Livingmentioning

confidence: 99%

Section: Transgenic Pigs Must Have Lives Worth Livingmentioning

confidence: 99%

In defense of xenotransplantation research: Because of, not in spite of, animal welfare concerns

Bobier

Cooper

Hurst

et al. 2022

Xenotransplantation

View full text Add to dashboard Cite

show abstract

A Gross Comparative Anatomical Study of Hearts in Human Cadavers and Pigs

Garg

Singh

Sharma

et al. 2013

IJMDS

View full text Add to dashboard Cite

diameter and 6.6 cm (5cm-8cm) anteroposteriorly. The human heart was trapezoidal in shape. The pig heart, in contrast, was a broad cone shaped organ. In humans, the left atrium received the four pulmonary veins whereas in pig it received two pulmonary veins. In right atrium of man, orifices of superior and inferior caval veins were in a direct line whereas in pig veins opened at right angles to each other. The present study suggests that the morphology of human and porcine heart is almost similar with significant anatomical differences between porcine and human hearts that might effect the success of the cardiac xenograft within the human recipient.

show abstract

Rearing and Caring for a Future Xenograft Donor Pig

Cited by 2 publications

References 27 publications

In defense of xenotransplantation research: Because of, not in spite of, animal welfare concerns

In defense of xenotransplantation research: Because of, not in spite of, animal welfare concerns

A Gross Comparative Anatomical Study of Hearts in Human Cadavers and Pigs

Contact Info

Product

Resources

About