Reappraisal of Short-term Low-volume Hydration in Cisplatin-based Chemotherapy: Results of a Prospective Feasibility Study in Advanced Lung Cancer in the Okayama Lung Cancer Study Group Trial 1002

Abstract

This study demonstrated prospectively the feasibility of short-term low-volume hydration.

Safety of a short hydration method for cisplatin administration in comparison with a conventional method—a retrospective study

“…Single arm retrospective studies performed by Brock and Alberts (30), Tiseo et al (19) and Lavole et al (21) with patient numbers of 147, 107 and 357 showed the feasibility of short hydration for cisplatin administration. Four single arm prospective studies, one involving 44 patients and performed by Horinouchi et al (22), one involving 46 patients and performed by Hotta et al (23), one involving 45 patients and performed by Ninomiya et al (24) and one involving 46 patients and performed by Horinouchi et al (26) also demonstrated the safety of short hydration for cisplatin. In addition, Ouchi et al (27) retrospectively compared a short hydration protocol performed in 13 patients with a conventional hydration protocol performed in 17 patients and showed a similar safety between the two groups.…”

“…In this connection, magnesium supplementation was used in all six studies mentioned above. These studies, however, varied in the use of mannitol; three studies used it (22,23,30), while the studies by Tiseo et al (19) and Ouchi et al (27) used furosemide and that by Lavole et al (21) did not use any diuretic. Therefore, an optimal short hydration protocol remains to be established.…”

“…In addition, the National Comprehensive Cancer Network has made a short hydration protocol for cisplatin publically available. These trends have encouraged clinical researchers to perform retrospective (21) and prospective (22)(23)(24)(25)(26) studies to re-evaluate short hydration protocols for the administration of cisplatin. These single arm studies have demonstrated the safety of short hydration protocols, but only one retrospective study, with a limited patient number, has compared both short and conventional hydration protocols to examine safety (27).…”

Top 10 reasons why you must learn onco-nephrology

“…To give you an example, JJCO has published several clinical investigations (5)(6)(7)(8) on the optimal hydration with cisplatin administration. It was found that, compared with the traditional long hydration method which requires hospitalization, this new administration method with short hydration (5-7) and magnesium supplementation (8) Reason #3.…”

Chemotherapy for lung cancer: still alive!

“…This treatment strategy tended to show shorter OS than that observed with chemotherapy followed by TKIs (the WJTOG3405 trial showed 36% of patients did not receive platinum doublet chemotherapy) (4,5 in Table 1). Even now, there is a deep-rooted antipathy to chemotherapy despite the availability of drugs to control the nausea and vomiting induced by cisplatin and the fact that it may now be implemented in an outpatient setting (11,12). In addition, NSCLC harboring EGFR gene mutations are sensitive to chemotherapies.…”