Top 10 reasons why you must learn onco-nephrology

Kunitoh, Hideo

doi:10.1093/jjco/hyv166

Cited by 3 publications

(2 citation statements)

References 16 publications

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“…Radiation therapy was excluded from our analysis because it was thought that radiation had little effect on the kidney function [18]. We investigated whether the chemotherapeutic agents known to have nephrotoxicity including cisplatin, carboplatin, ifosfamide, gemcitabine, and pemetrexed were administered during the study period [19]. We reviewed the guidelines and chose the drugs based on the chemotherapy regimen of lung cancer used in our institution [20].…”

Section: Data Collectionmentioning

confidence: 99%

Clinical Significance of Acute Kidney Injury in Lung Cancer Patients

et al. 2021

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Acute kidney injury (AKI) in cancer patients is associated with increased morbidity and mortality. The incidence of AKI in lung cancer seems to be relatively higher compared with other solid organ malignancies, although its impact on patient outcomes remains unclear. Materials and MethodsThe patients newly diagnosed with lung cancer from 2004 to 2013 were enrolled in this retrospective cohort study. The patients were categorized according to the presence and severity of AKI. We compared all-cause mortality and long-term renal outcome according to AKI stage. ResultsA total of 3,202 patients were included in the final analysis. AKI occurred in 1,783 (55.7%) patients during the follow-up period, with the majority having mild AKI stage 1 (75.8%).During the follow-up of 2.6 ± 2.18 years, total 1,251 (53.7%) patients were died and 5-yr survival rate was 46.9%. We found that both AKI development and severity were independent risk factors for all-cause mortality in lung cancer patients, even after adjustment for lung cancerspecific variables including the stage or pathological type. In addition, patients suffered from more severe AKI tend to encounter de novo CKD development, worsening kidney function, and end-stage kidney disease progression. ConclusionIn this study, more than half of the lung cancer patients experienced AKI during their diagnosis and treatment period. Moreover, AKI occurrence and more advanced AKI were associated with a higher mortality risk and adverse kidney outcomes.

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Section: Data Collectionmentioning

confidence: 99%

Clinical Significance of Acute Kidney Injury in Lung Cancer Patients

et al. 2021

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“…Onconephrology is a new subspecialty that aims to improve treatment outcomes by focusing on the complex relationship between the kidneys and cancer 18,19 . Cancer can cause a variety of renal diseases.…”

Section: Case Reportmentioning

confidence: 99%

Primary Tumor Infiltration and Severe Acute Kidney Injury in Patients with Acute Myeloblastic Leukemia

et al. 2020

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In patients with hematologic malignancies, acute kidney injury (AKI) is the most common kidney complication requiring nephrologist consultation. Although the causes of AKI are multifactorial, primary tumor infiltration is rare in patients with acute myeloblastic leukemia (AML). This makes it challenging to determine the cause of AKI and the optimal chemotherapy regimen for AML. We describe two cases of AML (French-American-British classification: M2, M4) in patients with AKI requiring hemodialysis. We successfully identified the cause of AKI as primary leukemic infiltration and started induction chemotherapy in the setting of hemodialysis. This treatment significantly improved renal function and resulted in AML remission. In this report, we describe several clinical characteristics of AKI due to primary tumor infiltration. In addition, we emphasize the importance of onconephrology, a new subspecialty concerned with the complex relationship between the kidneys and cancer.

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Message from the New Editor-in-Chief

Kunitoh

2018

Japanese Journal of Clinical Oncology

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Top 10 reasons why you must learn onco-nephrology

Cited by 3 publications

References 16 publications

Clinical Significance of Acute Kidney Injury in Lung Cancer Patients

Clinical Significance of Acute Kidney Injury in Lung Cancer Patients

Primary Tumor Infiltration and Severe Acute Kidney Injury in Patients with Acute Myeloblastic Leukemia

Message from the New Editor-in-Chief

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