Reanalysis of the Final Results of the European Carotid Surgery Trial

Rothwell, Peter M.; Gutnikov, Sergei A.; Warlow, Charles

doi:10.1161/01.str.0000054671.71777.c7

Cited by 391 publications

(232 citation statements)

References 52 publications

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“…It has been suggested that patients with 50% to 69% stenosis may also expect some benefit from CEA. These findings were found consistent in the reanalysis of the data (Rothwell, Gutnikov, & Warlow 2003) and have been corroborated by an evidence-based review (Chaturvedi et al 2005). This latter report adds that asymptomatic patients with 60 -99% stenosis may benefit, if treated in this way, with peri-operative morbidity and mortality less than 3%.…”

Section: Treatment Of Carotid Diseasesupporting

confidence: 80%

Carotid atherosclerotic plaque characterisation by measurement of ultrasound sound speed in vitro at high frequency, 20MHz

Brewin¹,

Srodon²,

Greenwald³

et al. 2014

Ultrasonics

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Section: Treatment Of Carotid Diseasesupporting

confidence: 80%

Carotid atherosclerotic plaque characterisation by measurement of ultrasound sound speed in vitro at high frequency, 20MHz

Brewin¹,

Srodon²,

Greenwald³

et al. 2014

Ultrasonics

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“…[19][20][21][22] Outcome of these studies was a clinical cerebrovascular event, whether visible on computer tomography (CT) or not. As CMIs are too small to visualize on CT, they were not taken into account in this setting.…”

Section: Discussionmentioning

confidence: 99%

7.0 T MRI Detection of Cerebral Microinfarcts in Patients with a Symptomatic High-Grade Carotid artery Stenosis

Rotte

Köning

Hartog

et al. 2014

J Cereb Blood Flow Metab

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In the current study, the presence of cerebral cortical microinfarcts (CMIs) was evaluated in a series of 21 patients with a symptomatic high-grade 450% stenosis of the carotid artery. A T 2 -weighted fluid-attenuated inversion recovery sequence and a T 1 -weighted turbo field echo sequence of the brain were obtained at 7.0 Tesla magnetic resonance imaging. Primary study endpoint was the number of CMIs and macroinfarcts. In total, 53 cerebral infarcts (35 macroinfarcts; 18 CMIs) were found ipsilateral to the symptomatic carotid artery, in 14 patients (67%). In four of these patients, both CMIs and macroinfarcts were visible. In the contralateral hemisphere, seven infarcts (five macroinfarcts and two CMIs) were found in five patients (24%). In the ipsilateral hemispheres, the number of CMIs and macroinfarcts were significantly correlated (P = 0.02). Unpaired comparison of medians showed that the number of CMIs in the ipsilateral hemisphere was significantly higher than the number of CMIs in the contralateral hemisphere (P = 0.04). No significant correlation was found between stenosis grade and the number of any infarct. The current study shows that in symptomatic patients with significant extracranial carotid artery stenosis, CMIs are part of the total cerebrovascular burden and these CMIs prevail with a similar pattern as observed macroinfarcts.

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“…In this paper, the degree of stenosis is reported in percentages equivalent to the NASCET definition [23,24].…”

Section: Methodsmentioning

confidence: 99%

Genetic control of chemokines in severe human internal carotid artery stenosis

et al. 2008

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Background and purpose: Atherosclerosis is an inflammatory disease. Chemokines and chemokine receptors are known to be involved in atherogenesis. Common single nucleotide polymorphisms (SNPs) affect transcription in response to inflammatory stimuli. The aim of this study was to evaluate the correlations between MCP-1, RANTES, SDF-1, CCR2, and CCR5 gene polymorphisms with increased risk of internal carotid artery (ICA) stenosis. Methods: Hundred and twelve patients, consecutively recruited for ICA occlusive disease, and 282 controls were genotyped for MCP-1-2518G, RANTES-403A, CCR5D32, CCR2 V64I, and SDF-1-801A polymorphisms. Results: The frequency of the SDF-1A allele was significantly different between cases and controls: 0.32 vs. 0.20, respectively (OR 1.81; 95% CI 1.25-2.60; p = 0.007). The frequency of the RANTES-403G allele was significantly higher in patients with stenosis >70% (OR, 2.45; 95% CI 1.12-5.71; p = 0.015). No significant differences were observed with the other polymorphisms. Conclusion:The reported results seem to correlate the polymorphisms of the genes encoding for SDF-1, RANTES with pathogenesis and progression of ICA occlusive disease. Although suggestive, these results need confirmation in prospective cross-sectional studies.

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Reanalysis of the Final Results of the European Carotid Surgery Trial

Cited by 391 publications

References 52 publications

Carotid atherosclerotic plaque characterisation by measurement of ultrasound sound speed in vitro at high frequency, 20MHz

Carotid atherosclerotic plaque characterisation by measurement of ultrasound sound speed in vitro at high frequency, 20MHz

7.0 T MRI Detection of Cerebral Microinfarcts in Patients with a Symptomatic High-Grade Carotid artery Stenosis

Genetic control of chemokines in severe human internal carotid artery stenosis

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