Real-world impact of the high concentration non-avian high molecular weight hyaluronan on pain medication use among osteoarthritis patients

Chitnis, A.S.; Etter, Katherine; Holy, Chantal E.; Gray, F; Manalac, Fernando J.; Bisson, Brad

doi:10.1080/03007995.2019.1596670

Cited by 9 publications

(13 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…3,[33][34][35][36][37][38][39] Intra-articular HA injection may reduce the use of pain medications (Table 3). 3,33 In a retrospective claims analysis of patients who received their first IAHA injection between 2004 and 2011, McIntyre et al 3 found a 10% reduction in the average number of NSAID prescriptions filled and a 15% reduction in the number of patients receiving any NSAID prescription (P < .001). Furthermore, there was a 55% reduction in the average number of steroid injection prescriptions filled and a 57% reduction in the number of patients receiving any steroid prescription (P < .001).…”

Section: Health Care Resource Utilizationmentioning

confidence: 99%

Intra-articular Hyaluronic Acid for Osteoarthritis of the Knee in the United States: A Systematic Review of Economic Evaluations

Mordin

Parrish²,

Masaquel

et al. 2021

Clin Med�Insights�Arthritis�Musculoskelet Disord

Self Cite

View full text Add to dashboard Cite

Background: The economic impact of intra-articular hyaluronic acid (IAHA) for the treatment of knee pain associated with osteoarthritis (OA) has been evaluated in the United States, but not systematically summarized. Objective: We reviewed the literature to determine the economic impact of IAHA for pain associated with knee OA in the United States. Methods: A literature review was performed in PubMed (including MEDLINE and MEDLINE In-Process), Embase, the Cochrane Database of Systematic Reviews, and National Health Service Economic Evaluation Database and was limited to English language human studies published from January 2000 to October 2020. Results: The literature search identified 215 unique abstracts; of these, 47 were selected for full-text review and 21 studies met the inclusion criteria. Intra-articular hyaluronic acid injections delayed progression to total knee arthroplasty (TKA), and repeated courses of treatment successfully delayed TKA by more than 5 years. Intra-articular hyaluronic acid was found to reduce the use of pain medications overall and reduce the number of patients receiving opioid prescriptions by 6% ( P < .001). Several studies showed that IAHA is more cost-effective in treating pain associated with knee OA compared with conventional care with nonsteroidal anti-inflammatory drugs (NSAIDs), analgesics, and corticosteroids, and several authors concluded that IAHA should be the dominant treatment strategy. Conclusions: Current studies suggest that IAHA may reduce the use of pain medications, such as NSAIDs and opioids, and impact time to TKA procedures, thus potentially decreasing overall treatment costs of knee OA over time. Furthermore, IAHA was determined to be cost-effective against NSAIDs, corticosteroids, analgesics, and conservative treatment. As the safety and efficacy of IAHA for knee OA have been well established, the findings from our literature review may be used to inform future economic evaluations.

show abstract

Section: Health Care Resource Utilizationmentioning

confidence: 99%

Intra-articular Hyaluronic Acid for Osteoarthritis of the Knee in the United States: A Systematic Review of Economic Evaluations

Mordin

Parrish²,

Masaquel

et al. 2021

Clin Med�Insights�Arthritis�Musculoskelet Disord

Self Cite

View full text Add to dashboard Cite

show abstract

“…Not only was there a substantially lower percentage of opioid naive patients initiating use, more than half of the opioid users discontinued filling new opioid prescriptions after HA injection. Other clinical trials have also reported the reduced need for analgesic or rescue medication following HA use [17][18][19][20]. A 34.9% reduction in acetaminophen use at 52 weeks has been reported for patients who underwent repeated series of bioengineered HA [17].…”

Section: Discussionmentioning

confidence: 99%

“…A 34.9% reduction in acetaminophen use at 52 weeks has been reported for patients who underwent repeated series of bioengineered HA [17]. Chitnis and coworkers examined the utilization of nonsteroidal anti-inflammatory drugs (NSAIDs), CS injections, and opioids in the 6 months before and after HA treatment period, using commercial claims data [18]. In their cohort of 29,076 patients, the proportion of patients filling NSAID, CS injection, and opioid prescriptions decreased by 6, 28 and 4%, respectively.…”

Section: Discussionmentioning

confidence: 99%

“…16 on the first knee OA diagnosis during the data period, with at least a 6-month look-back period with no knee OA diagnosis. This was a mid-range look-back period based on prior studies [7,18,22,23] that have used 0-12 months to look-back for diagnosis of conditions and/or comorbidities. Patients were excluded if they had unknown age or gender, unknown state, enrollment gap of more than 3 months, with HA or KA before the first knee OA diagnosis or did not have pharmacy benefits.…”

Section: Methodsmentioning

confidence: 99%

“…Alternative, nonsurgical methods for knee pain management include intra-articular injections (corticosteroids [CS] or hyaluronic acid [HA]), physical therapy, weight loss, home exercise programs and use of nonsteroidal antiinflammatory drugs. The use of HA has been reported to reduce the need for analgesic or rescue medication [17][18][19][20]. However, the AAOS CPG did not recommend HA based on a meta-analysis of its clinical efficacy, while an inconclusive recommendation was provided for CS [3].…”

mentioning

confidence: 99%

See 2 more Smart Citations

Decrease in Opioid and Intra-Articular Corticosteroid Burden After Intra-Articular Hyaluronic Acid for Knee Osteoarthritis Treatment

et al. 2020

View full text Add to dashboard Cite

Aim: We studied changes in opioid prescriptions and corticosteroid injection use for knee osteoarthritis patients before and after intra-articular hyaluronic acid (HA) use and opioid prescriptions before and after knee arthroplasty (KA). Materials & methods: A total of 1,017,578 knee osteoarthritis members were ascertained from a commercial claims database (Health Intelligence Company LLC, IL, USA) using ICD9/ICD10 diagnosis codes. Results: Eighty two percent of HA patients did not fill opioid prescriptions postinjection, with 54% of opioid users discontinuing fills. Two-thirds of KA patients filled opioid prescriptions within 6 months postsurgery, with 78% of opioid users continuing fills and 62% of nonusers initiating use. Conclusion: Alternative therapies, such as HA, that reduce opioid use may alleviate opioid addiction risks for KA patients who use opioids in the pre- and postoperative periods.

show abstract

Different molecular weights of hyaluronan research in knee osteoarthritis: A state-of-the-art review

Lu²,

Lin

et al. 2023

Matrix Biology

View full text Add to dashboard Cite

Real-world impact of the high concentration non-avian high molecular weight hyaluronan on pain medication use among osteoarthritis patients

Cited by 9 publications

References 9 publications

Intra-articular Hyaluronic Acid for Osteoarthritis of the Knee in the United States: A Systematic Review of Economic Evaluations

Intra-articular Hyaluronic Acid for Osteoarthritis of the Knee in the United States: A Systematic Review of Economic Evaluations

Decrease in Opioid and Intra-Articular Corticosteroid Burden After Intra-Articular Hyaluronic Acid for Knee Osteoarthritis Treatment

Different molecular weights of hyaluronan research in knee osteoarthritis: A state-of-the-art review

Contact Info

Product

Resources

About