Different molecular weights of hyaluronan research in knee osteoarthritis: A state-of-the-art review

Lu, Ko-Hsiu; Lu, Peace Wun-Ang; Lin, Chiao‐Wen; Lu, Eric; Yang, Shun‐Fa

doi:10.1016/j.matbio.2023.02.006

Cited by 12 publications

(5 citation statements)

References 166 publications

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“…The molecular weight of sodium hyaluronate (10 mg/mL) used in Hyalgan is 500-730 kDa. It is obtained from rooster combs and is highly purified [34][35][36][37][38]. The other ingredients are sodium chloride, sodium dihydrogen phosphate dihydrate, disodium phosphate dodecahydrate and water.…”

Section: Methodsmentioning

confidence: 99%

The effect of hyaluronic acid concentration on the rheological and tribological properties of artificial synovial fluid base solutions

Grykin,

Klekotka,

Dąbrowski

2023

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Synovial joints are a basic part of the human body. Lack of proper lubrication of joints can lead to significant wear of their surfaces. The tribological and rheological properties of artificial synovial fluid solutions based on hyaluronic acid were studied. It was found that the concentration of selected hyaluronic acid solutions significantly affects the investigated parameters. The most promising results were obtained for 8 wt% hyaluronic acid solution, which showed the highest viscosity and wettability, and the lowest wear.

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Section: Methodsmentioning

confidence: 99%

The effect of hyaluronic acid concentration on the rheological and tribological properties of artificial synovial fluid base solutions

Grykin,

Klekotka,

Dąbrowski

2023

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“…Inflammation is a hallmark of rheumatic diseases [ 77 ], and HA plays a multifaceted role in this process [ 78 ]. Pathological conditions often lead to changes in the quantity and molecular weight of HA in synovial fluid, with implications for disease severity and progression [ 79 ]. During the inflammatory phase, HA actively participates in the recruitment and activation of immune cells, such as macrophages and neutrophils [ 79 ].…”

Section: Pathophysiological Role Of Hyaluronic Acid In Rheumatic Dise...mentioning

confidence: 99%

“…Pathological conditions often lead to changes in the quantity and molecular weight of HA in synovial fluid, with implications for disease severity and progression [ 79 ]. During the inflammatory phase, HA actively participates in the recruitment and activation of immune cells, such as macrophages and neutrophils [ 79 ]. HA engages with specific cell surface receptors, such as CD44 [ 80 ], and the binding affinity of HA to these receptors can vary depending on its molecular weight [ 81 ].…”

Section: Pathophysiological Role Of Hyaluronic Acid In Rheumatic Dise...mentioning

confidence: 99%

Hyaluronic Acid in Rheumatology

Sprott,

Fleck

2023

Pharmaceutics

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Hyaluronic acid (HA), also known as hyaluronan, is an anionic glycosaminoglycan widely distributed throughout various tissues of the human body. It stands out from other glycosaminoglycans as it lacks sulfation and can attain considerable size: the average human synovial HA molecule weighs about 7 million Dalton (Da), equivalent to roughly 20,000 disaccharide monomers; although some sources report a lower range of 3–4 million Da. In recent years, HA has garnered significant attention in the field of rheumatology due to its involvement in joint lubrication, cartilage maintenance, and modulation of inflammatory and/or immune responses. This review aims to provide a comprehensive overview of HA’s involvement in rheumatology, covering its physiology, pharmacology, therapeutic applications, and potential future directions for enhancing patient outcomes. Nevertheless, the use of HA therapy in rheumatology remains controversial with conflicting evidence regarding its efficacy and safety. In conclusion, HA represents a promising therapeutic option to improve joint function and alleviate inflammation and pain.

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“…Pharmacological treatments for KOA include nonsteroidal anti-inflammatory drugs, such as and acetaminophen, which have varying efficacy and can only provide short-term relief of inflammation and pain [ 9 , 10 ]. There are also long-term medications like tricyclic antidepressants such as amitriptyline and opioids.…”

Section: Introductionmentioning

confidence: 99%

The impact of Yoga on patients with knee osteoarthritis: A systematic review and meta-analysis of randomized controlled trials

Lu,

Kang,

Huang

et al. 2024

PLoS ONE

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Objective The objective of this review is to conduct a comprehensive and systematic assessment of the efficacy of Yoga as an intervention for knee osteoarthritis (KOA). Methods We searched PubMed, Cochrane Library, Embase, Web of Science, and PEDro as of January 3, 2024. Retrieved a total of 200 articles. Standardised mean differences (SMDs) and 95% confidence intervals (CI) were calculated. Results The study included a total of 8 trials and involved 756 KOA patients. The results indicated that compared to the control group, Yoga exercise showed significant improvements in alleviating pain (SMD = -0.92; 95% CI = -1.64 ~ - 0.20; P = 0.01, I2 = 94%), stiffness (SMD = -0.51; 95% CI = -0.91 ~ -0.12; P = 0.01; I2 = 66%) and physical function (SMD = -0.53; 95% CI = -0.89 ~ -0.17; P = 0.004; I2 = 59%) among KOA patients. However, there was no significant improvement observed in terms of activities of activity of daily living (ADL) (SMD = 1.03; 95% CI = -0.01 ~ 2.07; P = 0.05; I2 = 84%), and quality of life (QOL) (SMD = 0.21; 95% CI = -0.33 ~ 0.74; P = 0.44; I2 = 83%) with the practice of Yoga. Conclusions In general, Yoga has been found to be effective in reducing pain and stiffness in KOA patients, it can also improve the physical function of patients. However, there is limited evidence to suggest significant improvements in terms of ADL and QOL.

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Different molecular weights of hyaluronan research in knee osteoarthritis: A state-of-the-art review

Cited by 12 publications

References 166 publications

The effect of hyaluronic acid concentration on the rheological and tribological properties of artificial synovial fluid base solutions

The effect of hyaluronic acid concentration on the rheological and tribological properties of artificial synovial fluid base solutions

Hyaluronic Acid in Rheumatology

The impact of Yoga on patients with knee osteoarthritis: A systematic review and meta-analysis of randomized controlled trials

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