Real-world burden of comorbidities in US patients with psoriasis

Shah, K.; Mellars, L.; Changolkar, Arun; Feldman, Steven R.

doi:10.1016/j.jaad.2017.03.037

Cited by 75 publications

(77 citation statements)

References 27 publications

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“…Patients with psoriasis have a higher prevalence of cardiovascular disease, metabolic syndrome and its individual components such as hypertension, diabetes, hyperlipidemia and abdominal obesity, varying according to disease severity. [20][21][22][23][24] A multitude of psychological comorbidities ranging from anxiety, depression, low affective expression, low problem-solving skills, sleep disturbances, sexual dysfunction and suicidal ideation are also linked with psoriasis. [25][26][27] Psoriasis is associated with impaired quality of life (QoL) to a degree comparable with that in diseases such as malignancy, heart disease and diabetes.…”

Section: Clinical Features and Comorbiditiesmentioning

confidence: 99%

Asian consensus on assessment and management of mild to moderate plaque psoriasis with topical therapy

Imafuku

Zheng

Tada

et al. 2018

The Journal of Dermatology

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A working group of dermatologists in Asian countries assessed the current status of psoriatic management in the region to prepare a consensus report on topical treatment in mild to moderate plaque psoriasis. Even though the association of psoriasis with systemic comorbidities is increasingly acknowledged, psoriasis is still lower in health‐care priority lists in the region. The psychosocial impact of psoriasis may be greater in Asian countries due to cultural norms and social discrimination. Non‐adherence to treatment is also common among Asians. The current care given to patients with mild to moderate psoriasis needs to be streamlined, enhanced and organized with a patient‐centered care approach to achieve better outcomes. A comprehensive assessment of the disease severity and its impact on a patient's life is required before initiating treatment. Education and active involvement of the patient in the treatment plan is an important part of psoriatic management. It is recommended to personalize topical treatment to meet the needs of the patient, depending on disease severity, psychosocial impact, the patient's expectations and, more importantly, the patient's willingness and ability to actively follow the treatment procedure. Fixed‐dose combination of corticosteroid and vitamin D analogs is the preferred topical medication for both initial and maintenance phases of treatment. The fast containment of the disease is the goal of the initial phase of 4–8 weeks and it demands a potent fast‐acting topical therapy. Satisfactory control of the disease and prevention of relapses should be achieved during the maintenance phase with twice a week or weekend applications.

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Section: Clinical Features and Comorbiditiesmentioning

confidence: 99%

Asian consensus on assessment and management of mild to moderate plaque psoriasis with topical therapy

Imafuku

Zheng

Tada

et al. 2018

The Journal of Dermatology

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“…P soriasis is a chronic, inflammatory cutaneous disorder affecting skin, nails and joints, often associated with various comorbidities, and posing a severe psychosocial burden in affected individuals (1,2). Psoriasis is common in the general population, with an estimated prevalence in the general population of 1-4.4% (3)(4)(5).…”

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confidence: 99%

Itch in Psoriasis: A New Look at Well-known Subject

Reszke¹,

Białynicki‐Birula²,

Szepietowski³

2019

Acta Derm Venerol

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SIGNIFICANCEPsoriasis is a chronic inflammatory cutaneous disease fre quently encountered in the general population. The majo rity of psoriatic patients experience chronic itch. The cur rent study has extensively evaluated the prevalence and clinical characteristics of chronic itch in a cohort of psoriatic subjects. Moreover, we have investigated clinical itch-rela ted differences between senior and non-senior groups of patients, as well as possible associations between chronic itch, systemic comorbidities and pharmacotherapy.Psoriasis is a chronic inflammatory dermatosis, frequently presenting with chronic itch. This study investigated the prevalence and detailed clinical characteristics of chronic itch in 143 psoriatic patients, with regard to different age groups, comorbidities and pharmacotherapy. Chronic itch was reported by 72% of subjects. Patients aged 65 years and over presented higher 4-Item Itch Questionnaire (4IIQ) scores (8.6 ± 3.4 vs. 7.4 ± 2.5 points; p = 0.03) and rarely experienced itching at midday (p = 0.009). Chronic itch correlated with aspirin intake and xerosis intensity. 4IIQ scores were higher in patients with asthma/chronic obstructive pulmonary disease, peptic ulcer disease and those taking insulin. Logistic regression analysis found that chronic itch was positively correlated with the use of antacids, angiotensin receptor blockers, angiotensin enzyme converting inhibitors, beta-blockers, xerosis intensity and Physician's Global Assessment score, whereas psychiatric drugs other than selective serotonin reuptake inhibitors, allopurinol, coexistence of arterial hypertension and application of emollients acted conversely. Elderly psoriatic patients present several differences in the characteristics of chronic itch, and chronic itch may be associated with comorbidities and pharmacotherapy. To the best of our knowledge, this is the first study to report possible associations between psoriatic pruritus and co-administration of drugs utilized in various systemic conditions. ActaDV ActaDV Advances in dermatology and venereologyActa Dermato-Venereologica R. Reszke et al. 430 www.medicaljournals.se/acta ActaDV ActaDV Advances in dermatology and venereology Acta Dermato-Venereologica R. Reszke et al. 432 www.medicaljournals.se/acta ActaDV ActaDV Advances in dermatology and venereology Acta Dermato-Venereologica 433 Itch in psoriasis Acta Derm Venereol 2019 ActaDV ActaDV Advances in dermatology and venereology Acta Dermato-Venereologica R. Reszke et al. 434

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“…Findings in this pediatric study are similar to trends for comorbidities in adults with psoriasis. For instance, adult psoriasis is associated with a higher prevalence of diabetes mellitus (1.22, 95% CI 1.11‐1.35) and rheumatologic disease (2.04, 95% CI 1.71‐2.42), as well as major depression (OR: 2.09, 95% CI 1.41‐3.11), and an incidence rate per 100 patient‐years of 18.81 for hyperlipidemia, 6.81 for obesity, and 7.36 for depression …”

Section: Discussionmentioning

confidence: 99%

A retrospective cohort study to evaluate the development of comorbidities, including psychiatric comorbidities, among a pediatric psoriasis population

Paller

Schenfeld²,

Accortt

et al. 2019

Pediatric Dermatology

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Background/Objective Compared with the adult psoriasis population, knowledge about the incidence of comorbidities in the pediatric psoriasis population is limited. The objective of this study was to assess the prevalence and incidence of comorbidities, including psychiatric comorbidities, in patients with pediatric psoriasis. Methods In this claims‐based, retrospective cohort study, patients with pediatric psoriasis were matched 1:3 with a nonpsoriasis cohort based on age, sex, and index date (the earliest of inpatient claims or the latter of two outpatient claims). Results Obesity, serious infection, and juvenile idiopathic arthropathy had higher prevalence and incidence rates in the psoriasis cohort than the nonpsoriasis cohort. Psychiatric comorbidities were also more common in the psoriasis cohort than the nonpsoriasis cohort, as were ulcerative colitis and Crohn disease. Stratifying the psoriasis cohort by disease severity—mild and moderate‐to‐severe—found no differences in incidence rates of comorbidities between the two subsets. Conclusion The incidence rates of many comorbid conditions were higher for patients with pediatric psoriasis compared with patients without pediatric psoriasis, and similar between patients with moderate‐to‐severe and mild pediatric psoriasis.

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Real-world burden of comorbidities in US patients with psoriasis

Cited by 75 publications

References 27 publications

Asian consensus on assessment and management of mild to moderate plaque psoriasis with topical therapy

Asian consensus on assessment and management of mild to moderate plaque psoriasis with topical therapy

Itch in Psoriasis: A New Look at Well-known Subject

A retrospective cohort study to evaluate the development of comorbidities, including psychiatric comorbidities, among a pediatric psoriasis population

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