A retrospective cohort study to evaluate the development of comorbidities, including psychiatric comorbidities, among a pediatric psoriasis population

Abstract

Background/Objective Compared with the adult psoriasis population, knowledge about the incidence of comorbidities in the pediatric psoriasis population is limited. The objective of this study was to assess the prevalence and incidence of comorbidities, including psychiatric comorbidities, in patients with pediatric psoriasis. Methods In this claims‐based, retrospective cohort study, patients with pediatric psoriasis were matched 1:3 with a nonpsoriasis cohort based on age, sex, and index date (the earliest of inpatient claims or the latter of two outpatient claims). Results Obesity, serious infection, and juvenile idiopathic arthropathy had higher prevalence and incidence rates in the psoriasis cohort than the nonpsoriasis cohort. Psychiatric comorbidities were also more common in the psoriasis cohort than the nonpsoriasis cohort, as were ulcerative colitis and Crohn disease. Stratifying the psoriasis cohort by disease severity—mild and moderate‐to‐severe—found no differences in incidence rates of comorbidities between the two subsets. Conclusion The incidence rates of many comorbid conditions were higher for patients with pediatric psoriasis compared with patients without pediatric psoriasis, and similar between patients with moderate‐to‐severe and mild pediatric psoriasis.

Efficacy and safety of ixekizumab in a phase III , randomized, double‐blind, placebo‐controlled study in paediatric patients with moderate‐to‐severe plaque psoriasis ( IXORA ‐ PEDS )

“…Paediatric plaque psoriasis affects approximately 1% of children and adolescents, and is estimated to occur first before 20 years of age in 35–50% of adults with plaque psoriasis . Paediatric psoriasis can be associated with reduced quality of life and a higher incidence of multiple comorbidities, including psoriatic arthritis, obesity, diabetes, Crohn's disease, ulcerative colitis and psychiatric comorbidities . Thus, early recognition and treatment of paediatric psoriasis are important for overall health and quality of life.…”

Psoriasis Comorbidities in Childhood

“…Известно, что псориаз у взрослых связан с коморбидными заболеваниями, ряд которых объединен термином «псориатический марш»: системное воспаление у больных псориазом вначале способствует развитию инсулинорезистентности, затем сахарного диабета, что в дальнейшем приводит к эндотелиальной дисфункции, затем к развитию атеросклероза и его осложнений в виде инфаркта миокарда и инсульта [4]. Среди последних выделяют метаболический синдром, гиперлипидемию, ожирение, сердечно-сосудистые заболевания (гипертоническая болезнь, ишемическая болезнь сердца), сахарный диабет и др.…”

“…Среди последних выделяют метаболический синдром, гиперлипидемию, ожирение, сердечно-сосудистые заболевания (гипертоническая болезнь, ишемическая болезнь сердца), сахарный диабет и др. Данные о распространенности основных коморбидностей псориаза отражены в таблице [4]. Эти заболевания нередко имеют общие с псориазом патогенетические особенности и способны напрямую влиять на течение болезни, прогноз и снижение качества жизни пациентов [3].…”

“…Вышеназванные патологии у детей с псориазом встречаются в 3-4 раза чаще, чем в общей популяции [27,57]. При этом в ряде исследований показано, что болезнь Крона более прочно ассоциирована с заболеванием, чем язвенный колит [4]. Среди причин возникновения ВЗК у детей с псориазом выделяют генетическую предрасположенность и особенности иммунного ответа организма [27,58].…”

The prevalence of bipolar disorder in autoimmune disease: a systematic review and meta-analysis

“…The present study centered on several common autoimmune diseases with a: systemic lupus erythematosus, rheumatoid arthritis, psoriasis, multiple sclerosis, ulcerative colitis, Crohn's disease, ankylosing spondylitis, pemphigus, and Sjogren's syndrome. Ten cohort and case control studies from 2004 to the present (8)(9)(10)(11)(12)(13)(14)(15)(16)(17) were summarized, 16 groups of comparative data were included, and a metaanalysis was performed. We present the following article in accordance with the PRISMA reporting checklist (available at http://dx.doi.org/10.21037/apm-20-2293).…”