Real-time visualization of dynamic fractures in porcine bones and the loading-rate effect on their fracture toughness

Zhai, Xiaoling; Gao, Jinling; Nie, Yizhou; Guo, Zherui; Kedir, Nesredin; Claus, Benjamin; Sun, Tao; Fezzaa, Kamel; Xiao, Xianghui; Chen, Weinong W.

doi:10.1016/j.jmps.2019.07.010

Cited by 25 publications

(7 citation statements)

References 55 publications

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“…Cracks of rat bones receiving nesfatin-1 took a highly zig-zag path [ 4 ]. There were a large number of crack deflections in a short distance ( Figure 6 g–i).…”

Section: Resultsmentioning

confidence: 99%

“…Under physiological conditions, the bone is most often affected by the forces of compression, stretching, and bending. However, a bone fracture usually occurs as a result of a sudden trauma, a fall or impact, in which the bone is subjected to transverse forces [ 4 ]. Classical methods of examining the mechanical properties of bones are based on the quasi-static three-point bending test [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

“…Bone is not only an anisotropic but also a viscoelastic material. Its mechanical behaviors depend on the loading rate [ 4 ]. So far, few studies have been carried out on the impact test of whole bones.…”

Section: Introductionmentioning

confidence: 99%

“…The authors concluded that the bone response to compression revealed a foam-type behavior over the whole explored range of strain rates. Zhai et al [ 4 ] analyzed the loading rate effect on the fracture toughness of porcine bone specimens and found that the fracture initiation of cortical bone decreased as the loading rate increased. The impact of free-falling mass was well described for plant tissues [ 9 , 10 , 11 ] or engineering materials [ 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

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Effect of Nesfatin-1 on Rat Humerus Mechanical Properties under Quasi-Static and Impact Loading Conditions

et al. 2022

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The investigations on the response of bone tissue under different loading conditions are important from clinical and engineering points of view. In this paper, the influence of nesfatin-1 administration on rat humerus mechanical properties was analyzed. The classical three-point bending and impact tests were carried out for three rat bone groups: control (SHO), the humerus of animals under the conditions of established osteopenia (OVX), and bones of rats receiving nesfatin-1 after ovariectomy (NES). The experiments proved that the bone strength parameters measured under various mechanical loading conditions increased after the nesfatin-1 administration. The OVX bones were most susceptible to deformation and had the smallest fracture toughness. The SEM images of humerus fracture surface in this group showed that ovariectomized rats had a much looser bone structure compared to the SHO and NES females. Loosening of the bone structure was also confirmed by the densitometric and qualitative EDS analysis, showing a decrease in the OVX bones’ mineral content. The samples of the NES group were characterized by the largest values of maximum force obtained under both quasi-static and impact conditions. The energies absorbed during the impact and the critical energy for fracture (from the three-point bending test) were similar for the SHO and NES groups. Statistically significant differences were observed between the mean Fi max values of all analyzed sample groups. The obtained results suggest that the impact test was more sensitive than the classical quasi-static three-point bending one. Hence, Fi max could be used as a parameter to predict bone fracture toughness.

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“…Cracks of rat bones receiving nesfatin-1 took a highly zig-zag path [ 4 ]. There were a large number of crack deflections in a short distance ( Figure 6 g–i).…”

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effect of Nesfatin-1 on Rat Humerus Mechanical Properties under Quasi-Static and Impact Loading Conditions

et al. 2022

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“…In order to shed light on the complex bioregeneration of this type of major bone defect non-destructively in three dimensions and due to its excellent density resolution, synchrotron microtomography (SR-µCT) has been frequently applied to study samples from these bioregenerated femurs (3 and 6 months after implantation using bone tissue engineering) [20]. Advancing research by employing SR-µCT in situ studies of bioregenerated bone under axial load offers the unique opportunity to access information about its micro-mechanical properties as well as elasticity, especially for the case when large segmental discontinuity bone defects are studied-for example, with respect to density variations and variations in osseous microarchitecture which lead to cracks under load [30,45].…”

Section: Micromechanical Response Of Bio-regenerated Rat Bonementioning

confidence: 99%

TomoPress—In Situ Synchrotron-Based Microtomography under Axial Load

et al. 2020

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Computed tomography (CT) with hard X-rays is a mature technique that is in regular use to depict the interior of opaque specimens with spatial resolutions up to the micrometre range (microtomography or µCT). Short acquisition times and sophisticated contrast modes are accessible when synchrotron light sources are combined with microtomography—SR-µCT. Both features render SR-µCT as excellent probe to study delicate samples in situ, for example under mechanical load by deploying corresponding sample environments. The so-called TomoPress is such a device available within the public user programme of tomography beamline ID19 of the European Synchrotron Radiation Facility (ESRF). It allows one to study samples under high axial load (up to 500 N) with high spatial resolution up to the micrometer range. Different gauges are installed to allow online monitoring of the applied force. Constant humidity, temperature and wetting are routinely available as well. The article shall outline basic design principles of the press as well as parameters for its utilisation in a descriptive manner. Selected examples underline the potential of the device for such diverse fields as biomedical research, life sciences and materials research.

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Fatigue behavior of cortical bone: a review

Gong

2020

Acta Mech. Sin.

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Real-time visualization of dynamic fractures in porcine bones and the loading-rate effect on their fracture toughness

Cited by 25 publications

References 55 publications

Effect of Nesfatin-1 on Rat Humerus Mechanical Properties under Quasi-Static and Impact Loading Conditions

Effect of Nesfatin-1 on Rat Humerus Mechanical Properties under Quasi-Static and Impact Loading Conditions

TomoPress—In Situ Synchrotron-Based Microtomography under Axial Load

Fatigue behavior of cortical bone: a review

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