Effect of Nesfatin-1 on Rat Humerus Mechanical Properties under Quasi-Static and Impact Loading Conditions

Skic, Anna; Puzio, Iwona; Tymicki, Grzegorz; Kołodziej, Paweł; Pawłowska-Olszewska, Marta; Skic, Kamil; Beer–Lech, Karolina; Bieńko, Marek; Gołacki, Krzysztof

doi:10.3390/ma15010333

Cited by 3 publications

(3 citation statements)

References 37 publications

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“…The authors stated that for higher loading rates the bone exhibited lower fracture toughness. Similar results were obtained by Skic et al, [18], who showed that the force needed to fracture under dynamic loads was lower than the force at fracture under quasi-static conditions.…”

Section: Introductionsupporting

confidence: 90%

“…The mass moment of inertia of the pendulum arm I P = 0.072 kg•m 2 allowed to obtain a constant velocity (V I ) during the impact. Before starting the test, the pendulum was set vertically, the angular displacement sensor readings were zeroed, and then the arm was defl ected by an angle of 9.15° that allowed to obtain a specifi c speed value V I = 0.5 m•s -1 [18][19][20].…”

Section: Methodsmentioning

confidence: 99%

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Methodological Aspects of Rat Bone Mechanical Impact

Skic¹,

Kołodziej²,

Puzio³

et al. 2022

Adv. Sci. Technol. Res. J.

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A three-point bending test under quasi-static load conditions is usually used in studies on the bones' mechanical properties. On its basis, the bone strength is determined, corresponding to the maximum force required for the fracture. In natural conditions, bone fractures most often occur as a result of an impact or fall, i.e. under dynamic loads, when a large force acts on the bone in a concise time. This work presents the results of a dynamic two-point bending test of rat bones. Two groups of the humerus were analyzed: healthy (as a control) and ovariectomized rats (as an osteoporosis model). During the bending test in the analyzed bone cross-section, a complex state of the surface density of internal forces will appear, characterized by the simultaneous occurrence of normal and tangential stresses. The obtained results determined the influence of osteoporotic changes on the transmitted dynamic forces values. The values of tensile and compressive stresses occurring at bone fracture were dependent rather on the bone asymmetry, the moment of inertia of its cross-section, and material properties than the loading force.

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Section: Introductionsupporting

confidence: 90%

Section: Methodsmentioning

confidence: 99%

Methodological Aspects of Rat Bone Mechanical Impact

Skic¹,

Kołodziej²,

Puzio³

et al. 2022

Adv. Sci. Technol. Res. J.

View full text Add to dashboard Cite

show abstract

“…COX-2, IL-6 and IL-8 in human primary chondrocytes in patients with osteoarthritis ( 30 ); it may play a role in pathogenesis or osteoarthritis, although the exact pathogenesis remains undefined ( 30 , 87 , 88 ). Pre-clinical studies have shown nesfatin-1 to be protective of bone tissue in rodents ( 31 , 32 ). Thus it was suggested that this adipokine may be used therapeutically in the management of OP ( 89 ).…”

Section: Introductionmentioning

confidence: 99%

The role of adipokines in osteoporosis management: a mini review

Patil,

Fredericks

2024

Front. Endocrinol.

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The prevalence of osteoporosis has been on the rise globally. With ageing populations, research has sought therapeutic solutions in novel areas. One such area is that of the adipokines. Current literature points to an important role for these chemical mediators in relation to bone metabolism. Well-established adipokines have been broadly reported upon. These include adiponectin and leptin. However, other novel adipokines such as visfatin, nesfatin-1, meteorin-like protein (Metrnl), apelin and lipocalin-2 are starting to be addressed pre-clinically and clinically. Adipokines hold pro-inflammatory and anti-inflammatory properties that influence the pathophysiology of various bone diseases. Omentin-1 and vaspin, two novel adipokines, share cardioprotective effects and play essential roles in bone metabolism. Studies have reported bone-protective effects of omentin-1, whilst others report negative associations between omentin-1 and bone mineral density. Lipocalin-2 is linked to poor bone microarchitecture in mice and is even suggested to mediate osteoporosis development from prolonged disuse. Nesfatin-1, an anorexigenic adipokine, has been known to preserve bone density. Animal studies have demonstrated that nesfatin-1 treatment limits bone loss and increases bone strength, suggesting exogenous use as a potential treatment for osteopenic disorders. Pre-clinical studies have shown adipokine apelin to have a role in bone metabolism, mediated by the enhancement of osteoblast genesis and the inhibition of programmed cell death. Although many investigations have reported conflicting findings, sufficient literature supports the notion that adipokines have a significant influence on the metabolism of bone. This review aims at highlighting the role of novel adipokines in osteoporosis while also discussing their potential for treating osteoporosis.

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Novel Adipokines and Their Role in Bone Metabolism: A Narrative Review

2023

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The growing burden of obesity and osteoporosis is a major public health concern. Emerging evidence of the role of adipokines on bone metabolism has led to the discovery of novel adipokines over the last decade. Obesity is recognized as a state of adipose tissue inflammation that adversely affects bone health. Adipokines secreted from white adipose tissue (WAT) and bone marrow adipose tissue (BMAT) exerts endocrine and paracrine effects on the survival and function of osteoblasts and osteoclasts. An increase in marrow fat is implicated in osteoporosis and, hence, it is crucial to understand the complex interplay between adipocytes and bone. The objective of this review is to summarize recent advances in our understanding of the role of different adipokines on bone metabolism. Methods: This is a comprehensive review of the literature available in PubMED and Cochrane databases, with an emphasis on the last five years using the keywords. Results: Leptin has shown some positive effects on bone metabolism; in contrast, both adiponectin and chemerin have consistently shown a negative association with BMD. No significant association was found between resistin and BMD. Novel adipokines such as visfatin, LCN-2, Nesfatin-1, RBP-4, apelin, and vaspin have shown bone-protective and osteoanabolic properties that could be translated into therapeutic targets. Conclusion: New evidence suggests the potential role of novel adipokines as biomarkers to predict osteoporosis risk, and as therapeutic targets for the treatment of osteoporosis.

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Effect of Nesfatin-1 on Rat Humerus Mechanical Properties under Quasi-Static and Impact Loading Conditions

Cited by 3 publications

References 37 publications

Methodological Aspects of Rat Bone Mechanical Impact

Methodological Aspects of Rat Bone Mechanical Impact

The role of adipokines in osteoporosis management: a mini review

Novel Adipokines and Their Role in Bone Metabolism: A Narrative Review

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