Real-time spatial compound sonography of Achilles tendon in patients with heterozygous familial hypercholesterolaemia and normal physical examination

Bartolotta, Tommaso Vincenzo; Taibbi, Adele; Malizia, G; Mamone, Giuseppe; Barbagallo, Carlo M.; Midiri, Massimo; Lagalla, Roberto

doi:10.1007/s11547-007-0162-4

Cited by 5 publications

(3 citation statements)

References 26 publications

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“…The main novel aspect of our study is that we used MR imaging-based fatwater separation and tendon volume to study tendon xanthomas at baseline and after treatment. Tendon volume measurement is clearly relevant given that size is a prime indicator of xanthoma severity (5,29), whereas fat-water separation enables the pathophysiology of tendon xanthomas to be studied and provides another potential measure of treatment response other than tendon size.…”

Section: Control Subjects Versus Patients With Fh At Baselinementioning

confidence: 99%

Achilles Tendon Xanthomas: Fat-Water Separation at Baseline and after Treatment

Griffith

Yeung

et al. 2017

Radiology

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Purpose To investigate the fat-water content of Achilles tendon xanthomas at baseline and after treatment and to compare this assessment with that of ultrasonography (US) and other magnetic resonance (MR) imaging-based parameters. Materials and Methods Forty-eight Achilles tendons with clinically apparent xanthomas in 24 patients with familial hypercholesterolemia (FH) (six men, 18 women; mean age ± standard deviation, 58 years ± 9) were compared with 20 Achilles tendons in 10 control subjects without FH (two men, eight women; mean age, 62 years ± 7). US imaging measurements (thickness, width, cross-sectional area, echogenicity) and 3.0-T MR imaging measurements (thickness, width, cross-sectional area, volume, and fat-water separation) of the Achilles tendons were obtained at baseline and in patients with FH at 3 and 6 months after treatment with probucol, a cholesterol-lowering agent. Nonparametric tests compared baseline data, whereas repeated-measures analyses assessed treatment change. Results At baseline, all US and MR imaging-based parameters were higher in xanthoma tendons compared with those in control tendons (all P < .05). The mean relative water content per unit volume was 71% higher (42.0% ± 6.7) in xanthoma tendons than in control tendons (24.5% 6 5.8; P < .001). After 6 months of cholesterol-lowering treatment, only MR imaging measurements of tendon volume (P = .007), relative fat (P = .041), and relative water content (P < .001) showed significant changes. As relative tendon fat content decreased with treatment, relative water content increased. Conclusion Most of the enlargement of Achilles tendon xanthomas is due to an increase in water content rather than fat. For depicting treatment change, relative tendon water content was the most sensitive parameter, followed by tendon volume and relative tendon fat content. RSNA, 2017 Online supplemental material is available for this article.

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Section: Control Subjects Versus Patients With Fh At Baselinementioning

confidence: 99%

Achilles Tendon Xanthomas: Fat-Water Separation at Baseline and after Treatment

Griffith

Yeung

et al. 2017

Radiology

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“…1). Ausschlusskriterium war neben akuten und chronischen Beschwerden von Patella-und Achillessehnen das Vorliegen von Systemerkrankungen (Hypercholesterinämie, Hyperurikämie, Kollagenosen) oder bestehende Vorerkrankungen aus dem rheumatischen Formenkreis [22,23]. Die aktuelle Einnahme von Antibiotika oder nicht steroidalen Antiphlogistika führte ebenso zum Ausschluss.…”

Section: Probandenunclassified

Intra- und interobserver Variabilität sonografischer Untersuchungen an Patella- und Achillessehnen

Cassel¹,

Müller²,

Carlsohn³

et al. 2012

Sportverletz Sportschaden

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“…16 Another recent study showed that compound sonography is an effective tool in the assessment of Achilles tendon xanthomas in patients with heterozygous familial hypercholesterolemia and normal physical examination, providing better quality images when compared with high resolution ultrasonography. 17 A study of 125 patients (67 operative, 58 nonoperative) followed with ultrasound examined re-rupture rates when operative intervention was performed if a gap greater than 5 mm existed on ultrasound after immobilization of the ankle in maximal plantar flexion. No significant difference was found in re-rupture rates (two in nonoperative and one in operative) when this criterion was used.…”

Section: Biology and Physiologymentioning

confidence: 99%