Real time shear wave elastography in chronic liver diseases: Accuracy for predicting liver fibrosis, in comparison with serum markers

Abstract

SWE showed a significant correlation with the severity of liver fibrosis and was useful and accurate to predict significant and advanced fibrosis, comparable with serum markers.

Validation of Shear Wave Elastography Cutoff Values on the Supersonic Aixplorer for Practical Clinical Use in Liver Fibrosis Staging

“…Previous SWE studies have proposed various cutoff values for distinguishing different fibrosis stages, such as early/no fibrosis, advanced fibrosis and cirrhosis (Beland et al 2014; Jeong et al 2014; Samir et al 2015; Sporea et al 2014). Some of these studies have focused on identifying cutoff values for the diagnosis of METAVIR fibrosis stage F2 and higher (Beland et al 2014; Jeong et al 2014; Samir et al 2015).…”

“…Some of these studies have focused on identifying cutoff values for the diagnosis of METAVIR fibrosis stage F2 and higher (Beland et al 2014; Jeong et al 2014; Samir et al 2015). However, these cutoff values have been generated from single data sets and have not, to our knowledge, subsequently been validated on independent cohorts.…”

“…As a noninvasive, inexpensive and portable technique, ultrasound elastography has shown promising results (Chon et al 2012; Friedrich-Rust et al 2012; Friedrich-Rust et al 2008). In particular, shear-wave elastography (SWE) derived estimates of shear-wave speed and hepatic Young’s modulus (eYM) have been shown to be related to liver fibrosis stage, (Beland et al 2014a; Deffieux et al 2015; Feng et al 2016; Jeong et al 2014; Sporea et al 2014; Tada et al 2015; Zheng et al 2015) and cutoff eYM or shear-wave speed values for different liver fibrosis stages have been proposed in a number of studies (Beland et al 2014b; Jeong et al 2014; Samir et al 2015). A recent meta-analysis of SWE studies summarizes this dilemma where in 12 manuscripts reviewed have generated 12 different cutoff values for variable sensitivities and specificities (Feng et al 2016).…”

Role of Point Shear Wave Elastography in the Determination of the Severity of Fibrosis in Pediatric Liver Diseases With Pathologic Correlations

“…Noninvasive quantitative methods such as point shear wave elastography are used to measure tissue stiffness . An alternative method of biopsy in children is becoming increasingly necessary.…”

Combined acoustic radiation force impulse, aminotransferase to platelet ratio index and Forns index assessment for hepatic fibrosis grading in hepatitis B

“…One of the advantages of APRI and Forns index over the other noninvasive tests is that they are based on readily available blood tests and simple to use. Although these strategies have been widely applied in the past decade for hepatitis C evaluation [15,16] , their accuracy for CHB grading are still not comparable with liver biopsy. Therefore, a combined use of these non-invasive methods may be another promising and practical diagnostic application in CHB patients.…”