Role of Point Shear Wave Elastography in the Determination of the Severity of Fibrosis in Pediatric Liver Diseases With Pathologic Correlations

Özkan, Mehmet Burak; Bilgici, Meltem Ceyhan; Eren, Esra; Çaltepe, Gönül; Yılmaz, Gülay Can; Kara, Cengiz; Gün, Seda

doi:10.1002/jum.14277

Cited by 32 publications

(35 citation statements)

References 18 publications

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“…In a series of 75 children, SWV cut offs were 1.67 m/s for pSWE and 1.56 m/s for 2D-SWE in detecting fibrosis or inflammation and 2.09 m/s for pSWE and 2.17 m/s for 2D-SWE in discriminating children with low and high histological liver fibrosis scores. However, both techniques had limited success rates when differentiating low-grade fibrosis from normal liver tissue [14]. In another prospective study, pSWE was feasible in children using both the convex and the linear transducers.…”

Section: Point Swe (Pswe)mentioning

confidence: 99%

Current Knowledge in Ultrasound-Based Liver Elastography of Pediatric Patients

et al. 2018

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Featured Application: In this review we present and discuss the published literature on the use of ultrasound-based liver elastography in children. The published data show that all the available shear wave elastography techniques are feasible and accurate for the assessment of liver fibrosis in children with diffuse liver disease due to several etiologies. For the assessment of focal liver lesions evidences are limited and no conclusion can be drawn so far.Abstract: Studies performed using transient elastography (TE), point shear wave elastography (pSWE) and two-dimensional shear wave elastography (2D-SWE) have shown that these techniques are all feasible and accurate in children for the evaluation of liver fibrosis due to several etiologies. However, for some specific pediatric pathologies, such as biliary atresia, the evidence is still limited. As shown in adults, inflammation is a confounding factor when assessing fibrosis severity and care should be taken when interpreting the results. Due to the scarce comparative data between serological tests and elastography techniques in children, a definite conclusion regarding which is the best cannot be drawn. Neither non-invasive elastographic techniques nor laboratory scores allow determination of the presence and the degree of inflammation, necrosis, iron or copper deposits.

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Section: Point Swe (Pswe)mentioning

confidence: 99%

Current Knowledge in Ultrasound-Based Liver Elastography of Pediatric Patients

et al. 2018

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“…Therefore, an association between SWS and pathological processes of the tumors was not able to be established. However, this was not the aim of the present study, as previous studies have demonstrated that the difference in the stiffness is associated with tissue reorganization, particularly fibrosis and necrosis ( 2 , 47 , 52 ). Secondly, the results of these experiments are not directly applicable to human liver cancer tissues: The present tumor model was implanted under the skin of the nude mice.…”

Section: Discussionmentioning

confidence: 86%

“…A variety of elastography techniques have been developed to visualize and quantify the mechanical properties of biological tissues, including thyroid, breast and liver tissues ( 1 , 2 ). In previous years, virtual touch tissue imaging and quantification (VTIQ), a novel two-dimensional shear wave speed (SWS) measurement technique, has been introduced into clinical practice, which not only provides qualitative but also quantitative measurements of the tissue stiffness ( 3 – 5 ).…”

Section: Introductionmentioning

confidence: 99%

VTIQ evaluates antitumor effects of NET‑1 siRNA by UTMD in HCC xenograft models

Liang

Shang

et al. 2018

Oncol Lett

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The present study used a virtual touch tissue imaging and quantification (VTIQ) method to investigate the change in elasticity in xenograft tumor tissue models following silencing of the neuroepithelial-transforming protein 1 (NET-1) gene by ultrasound-targeted microbubble destruction (UTMD). A total of 24 xenograft models were established by subcutaneous injection of human hepatocellular carcinoma SMMC-7721 cells in BALB/c female nude mice. Then, NET-1 small interfering RNA (siRNA)-conjugated nanobubbles and a glypican-3 antibody were synthesized. The mean and maximum shear wave speed (SWSmean and SWSmax) in the tumor tissue were measured prior to, during, and following therapy using VTIQ. The growth of the tumor size and survival time were recorded. The levels of NET-1 protein were evaluated by immunohistochemical staining. In addition, tumor, liver and kidney tissues of the nude mice were collected to confirm whether gene transfection treatment was toxic in vivo. In the UTMD delivery gene group, SWSmean was correlated with the maximum diameter of the tumor (r=0.9806, P=0.0194). The immunohistochemical staining data indicated that the level of NET-1 protein in the treated groups was significantly decreased compared with those in the control groups. Additionally, no structural damage was observed in the nude mice liver and kidney tissues following treatment. Therefore, VTIQ measurement identified potential changes in the elastic properties of the tumors, which in turn may be associated with the stages of tumor development. The delivery method, UTMD, improves the antitumor effects of NET-1 siRNA and supports gene transfection as a promising therapeutic strategy.

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“…Sonoelastography, which provides measurement of tissue stiffness, increases the diagnosis and progression of steatosis, and limits the value of early stage diagnosis in diseases such as NAFLD [7] . It has now led to the necessity of understanding the pathology of steatosis with the cause of increased incidence of obesity [7,8].…”

Section: Introductionmentioning

confidence: 99%

Effects of fatty filtration at the pediatric liver hemodynamic changes evaluated by Doppler ultrasonography

Özkan¹

2019

Ortadogu Tıp Derg

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Background: Hemodynamic changes in liver vascular structures of patients in the pediatric age group are evaluated by doppler ultrasonography. Material: Fifty-nine hepatosteatosis patients, classified as mild, moderate or severe, and 23 healthy volunteers were included in this 82-person study. The height, weight, liver size tests of the subjects were measured. Those values were compared in the patient and control groups. In the patient and control groups, color duplex Doppler ultrasonography was used to examine portal vein peak velocity, portal vein flow volume, hepatic artery resistive index (RI), hepatic artery pulsatility index (PI) and hepatic artery flow volume. Results: Similar to the degree of hepatosteatosis, increases in body mass index, liver size were statistically significant (p<0.05). The difference between portal vein peak velocity hepatosteatosis and control groups was found statistically significant. As the hepatosteatosis grade increased, there was no statistically significant decrease in hepatic arterial flow volume, portal vein flow volume, and total flow volume. Hepatic artery RI and PI values were statistically significantly lower in the control group than the other groups (p <0.05). There was a significant mild decrease in the mild stool group compared to the middle steat group. Although the hepatic artery RI and PI values did not differ statistically in the comparison of the hepatosteatosis group, there was a minimal increase in the RI and PI values as the steatosis grade increased. Discussion: According to these results, as the level of steatosis increases, the changes in the portal venous structures become more prominent and the resistance increases in vascular structures.

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Role of Point Shear Wave Elastography in the Determination of the Severity of Fibrosis in Pediatric Liver Diseases With Pathologic Correlations

Abstract: The VTQ and VTIQ values reveal high-grade histopathologic fibrosis and have high success rates when distinguishing high- from low-grade fibrosis. However, they have limited success rates when differentiating low-grade fibrosis from normal liver tissue.

Cited by 32 publications

References 18 publications

Current Knowledge in Ultrasound-Based Liver Elastography of Pediatric Patients

Current Knowledge in Ultrasound-Based Liver Elastography of Pediatric Patients

VTIQ evaluates antitumor effects of NET‑1 siRNA by UTMD in HCC xenograft models

Effects of fatty filtration at the pediatric liver hemodynamic changes evaluated by Doppler ultrasonography

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