Purpose: We examined the hypothesis that the fat-saturation pulse in a global oŠ-resonance state caused by magneticˆeld (B 0 ) drift produced signal ‰uctuation in echo planar imaging (EPI) time series.Methods: We performed 3 experiments using 2 types of phantoms, one of which was homemade and contained water and a well emulsiˆed fat source.Results: We found that B 0 drift was approximately +30 Hz in theˆrst 30-min EPI time series and +15 Hz in the second series. We experimentally reproduced the signal ‰uctua-tions observed during actual measurement in an artiˆcial global oŠ-resonance state using a fat-saturation pulse, the frequency proˆle of which also aŠected the pattern of ‰uctuation.Conclusion: These results are direct evidence that the fat-saturation pulse is a source of signal ‰uctuation in the presence of B 0 drift.