“…We purposely used the average-slice signal measuring method (ASM), 18 i.e., the mean value of all voxels (pixels) within a slice, instead of a measurement based on the region of interest (ROI) 1,21,22 to eliminate any spatial variations in the ‰uctuations caused by image shifting in a plane. The sum of the total pixel values through the plane were divided by the number of pixels: 64×64=4096 pixels/slice, giving S mean,i in Eq.…”