Real-time photoacoustic assessment of radiofrequency ablation lesion formation in the left atrium

Thao

et al. 2020

Sensors

Correct guiding of the catheter is a critical issue in almost all balloon catheter applications, including arterial stenosis expansion, coronary arterial diseases, and gastrointestinal tracking. To achieve safe and precise guiding of the balloon catheter, a novel imaging method with high-resolution, sufficient depth of penetration, and real-time display is required. Here, we present a new balloon catheter guiding method using fast photoacoustic microscopy (PAM) technique for precise balloon catheter tracking and visualization as a feasibility study. We implemented ex vivo and in vivo experiments with three different medium conditions of balloon catheter: no air, air, and water. Acquired cross-sectional, maximum amplitude projection (MAP), and volumetric 3D PAM images demonstrated its capability as a new imaging guiding tool for balloon catheter tracking and visualization.

Section: Introductionmentioning

confidence: 99%

Feasibility Study of Precise Balloon Catheter Tracking and Visualization with Fast Photoacoustic Microscopy

Thao

et al. 2020

Sensors

Journal of Biophotonics

“…Other RF hybrid technology platforms are trying to meet the key unmet requirements of radiofrequency catheter ablation, namely, real‐time lesion and tissue monitoring for the improvement of RF ablation accuracy and efficacy and the reduction of complications and re‐do procedures. Ultrasound [20] and optoacoustic [22–24] based hybrid technologies have the advantage of a higher penetration depth than OCT imaging. However, an “all optical” technology like OCT has the advantages of compactness and less susceptibility to electrical noise and interference coming from RF energy delivery.…”

Section: Discussionmentioning

confidence: 99%

“…Several RF hybrid technology platforms have been reported in the literature, including an optically‐guided RF catheter from Medlumics [16], an optical coherence tomography catheter for forward imaging [17], polarization based opticla coherence tomography [18], spectroscopic monitoring [19], a hybrid ultrasound/RF catheter from Phillips [20], a hybrid Near Field Ultra Sound/RF catheter [21] and hybrid RF/optoacoustic catheters [22–24].…”

Section: Introductionmentioning

confidence: 99%

Advanced fully integrated radiofrequency/optical‐coherence‐tomography irrigated catheter for atrial fibrillation ablation

Tiporlini

Ahderom

Pratten

et al. 2020

The inability of current catheter ablation procedures to accurately monitor lesion formation limits their safety and efficacy. An advanced fully integrated radiofrequency (RF)/optical coherence tomography (OCT) ablation catheter is developed, which enables real‐time monitoring during ablation. An OCT fiber array is especially designed, developed and integrated into an off‐the‐shelf irrigated RF ablation catheter. In‐vitro experimental studies performed on poultry and ovine hearts demonstrate the ability of the integrated RF/OCT system to provide information on the quality and orientation of catheter/wall contact. Experimental results show that adipose tissue can be accurately identified from normal myocardial tissue with 94% accuracy and lesion formation is monitored with an overall accuracy of 93%. The ability to predict pop events is also demonstrated, with an accuracy of 86%.

J. Innov. Opt. Health Sci.

“…4,18 To meet this clinical need, several catheter-based minimally invasive methods, such as intracardiac echocardiography, optical coherence tomography and photoacoustic, are being developed. [19][20][21][22][23] The laser Doppler technique presented in this paper has been evaluated in an in vivo animal model. Thermal application of the miocardium Fig.…”

Section: Discussionmentioning

confidence: 99%

Assessment of myocardial viability using a minimally invasive laser Doppler flowmetry on pig model

Litvinova

Stegemann

Leyva

2020

Background: The intra-operative real-time assessment of tissue viability can potentially improve therapy delivery and clinical outcome in cardiovascular therapies. Cardiac ablation therapy for the treatment of supraventricular or ventricular arrhythmia continues to be done without being able to assess if the intended lesion and lesion size have been achieved. Here, we report a method for continuous measurements of cardiac muscle microcirculation to provide an instrument for real-time ablation monitoring. Methods: We performed two acute open chest animal studies to assess the ability to perform real-time monitoring of creation and size of ablation lesion using a standard RF irrigated catheter. Radiofrequency ablation and laser Doppler were applied to different endocardial areas of alive open-chest pig. Results: We performed two experiments at three different RF ablation energy setting and different ablation times. Perfusion signals before and after ablation were found extensively and distinctively different. By increasing the ablation energy and time, the perfusion signal was decreasing. Conclusion: In vivo assessing the local microcirculation during RF ablation by laser Doppler can potentially be useful to differentiate between viable and nonviable ablated beating heart in real time.