Feasibility Study of Precise Balloon Catheter Tracking and Visualization with Fast Photoacoustic Microscopy

Kim, Jahae; Thao, Thi; Kim, Jin Young; Min, Jung‐Joon; Kim, Chulhong; Lee, Changho

doi:10.3390/s20195585

Cited by 10 publications

(7 citation statements)

References 56 publications

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“…The laser was controlled at approximately 5 mJ/cm 2 below the maximum ANSI limit (20 mJ/cm 2 under visible light). The measured axial and lateral resolutions were 27 and 14 µm, respectively [ 49 ], and are well matched to the theoretical values. The single B-scan was displayed at 1064 × 200 pixels using a 25 Hz frame rate.…”

Section: Methodssupporting

confidence: 59%

In Vivo Quantitative Vasculature Segmentation and Assessment for Photodynamic Therapy Process Monitoring Using Photoacoustic Microscopy

Thao

Yoo

Park

et al. 2021

Sensors

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Vascular damage is one of the therapeutic mechanisms of photodynamic therapy (PDT). In particular, short-term PDT treatments can effectively destroy malignant lesions while minimizing damage to nonmalignant tissue. In this study, we investigate the feasibility of label-free quantitative photoacoustic microscopy (PAM) for monitoring the vasculature changes under the effect of PDT in mouse ear melanoma tumors. In particular, quantitative vasculature evaluation was conducted based on Hessian filter segmentation. Three-dimensional morphological PAM and depth-resolved images before and after PDT treatment were acquired. In addition, five quantitative vasculature parameters, including the PA signal, vessel diameter, vessel density, perfused vessel density, and vessel complexity, were analyzed to evaluate the influence of PDT on four different areas: Two melanoma tumors, and control and normal vessel areas. The quantitative and qualitative results successfully demonstrated the potential of the proposed PAM-based quantitative approach to evaluate the effectiveness of the PDT method.

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Section: Methodssupporting

confidence: 59%

In Vivo Quantitative Vasculature Segmentation and Assessment for Photodynamic Therapy Process Monitoring Using Photoacoustic Microscopy

Thao

Yoo

Park

et al. 2021

Sensors

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“…This integrated scan system was used to drive the beam to scan the object’s surface, with a speed of 25 Hz B-scan. The data acquisition time for a mouse ear with an area of 10 × 12 mm is 180 s. The measured lateral and axial resolutions were 12 and 45 µm, respectively [ 21 ]. A LabVIEW program (National Instruments, Austin, TX, USA) was used to operate the OR-PAM system.…”

Section: Methodsmentioning

confidence: 99%

“…These benefits overcome the limited resolution of USI [ 18 , 19 , 20 ]. Moreover, PAM is a compact, inexpensive, non-ionized, label-free, functional, and real-time imaging modality [ 21 , 22 , 23 , 24 , 25 ]. It particularly aids the visualization of the distribution of intrinsic molecules in the body, such as hemoglobin, lipid, melanin, and proteins [ 26 , 27 , 28 , 29 , 30 , 31 ].…”

Section: Introductionmentioning

confidence: 99%

Pilot Study: Quantitative Photoacoustic Evaluation of Peripheral Vascular Dynamics Induced by Carfilzomib In Vivo

Thao

Chu

et al. 2021

Sensors

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Carfilzomib is mainly used to treat multiple myeloma. Several side effects have been reported in patients treated with carfilzomib, especially those associated with cardiovascular events, such as hypertension, congestive heart failure, and coronary artery disease. However, the side effects, especially the manifestation of cardiovascular events through capillaries, have not been fully investigated. Here, we performed a pilot experiment to monitor peripheral vascular dynamics in a mouse ear under the effects of carfilzomib using a quantitative photoacoustic vascular evaluation method. Before and after injecting the carfilzomib, bortezomib, and PBS solutions, we acquired high-resolution three-dimensional PAM data of the peripheral vasculature of the mouse ear during each experiment for 10 h. Then, the PAM maximum amplitude projection (MAP) images and five quantitative vascular parameters, i.e., photoacoustic (PA) signal, diameter, density, length fraction, and fractal dimension, were estimated. Quantitative results showed that carfilzomib induces a strong effect on the peripheral vascular system through a significant increase in all vascular parameters up to 50%, especially during the first 30 min after injection. Meanwhile, bortezomib and PBS do not have much impact on the peripheral vascular system. This pilot study verified PAM as a comprehensive method to investigate peripheral vasculature, along with the effects of carfilzomib. Therefore, we expect that PAM may be useful to predict cardiovascular events caused by carfilzomib.

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“…The omnidirectional nature of the PA signal enables angle-independent ablation catheter tip tracking. Several research groups have utilized PA imaging for guiding medical procedures that require the placement and positioning of external objects such as metallic needles [ 27 , 28 ], catheters [ 29 ], and balloon catheters [ 30 ]. Most of these reported methods are using external illumination to perform PA imaging.…”

Section: Introductionmentioning

confidence: 99%

Photoacoustic-guided endovenous laser ablation: Characterization and in vivo canine study

et al. 2021

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Endovenous laser ablation (EVLA) is a minimally invasive surgical procedure, often guided by ultrasound (US) imaging, for treating venous insufficiencies. US imaging limitations in accurately visualizing the catheter and the lack of a temperature monitoring system can lead to sub-optimal outcomes. An integrated photoacoustic (PA)-guided EVLA system has been previously developed and reported to overcome the shortcomings of US-guided procedure. In this study, we further characterized the system and tested the in vivo utility. In addition, PA thermometry was further explored by compensating the variation of PA signal with temperature with respect to the temperature-dependent absorption of blood and water. In vivo imaging results indicated that the PA-guided EVLA system can provide high contrast and accurate images of the ablation catheter tip overlaid on US images of the background tissue. Additionally, absorption-compensated PA signal amplitudes over a relevant range of temperature were measured and demonstrated.

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Feasibility Study of Precise Balloon Catheter Tracking and Visualization with Fast Photoacoustic Microscopy

Cited by 10 publications

References 56 publications

In Vivo Quantitative Vasculature Segmentation and Assessment for Photodynamic Therapy Process Monitoring Using Photoacoustic Microscopy

In Vivo Quantitative Vasculature Segmentation and Assessment for Photodynamic Therapy Process Monitoring Using Photoacoustic Microscopy

Pilot Study: Quantitative Photoacoustic Evaluation of Peripheral Vascular Dynamics Induced by Carfilzomib In Vivo

Photoacoustic-guided endovenous laser ablation: Characterization and in vivo canine study

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