Photoacoustic-guided endovenous laser ablation: Characterization and in vivo canine study

Yan, Yan; John, Samuel; Shaik, Tanyeem; Patel, Bijal; Lam, Mai T.; Kabbani, Loay; Mehrmohammadi, Mohammad

doi:10.1016/j.pacs.2021.100298

Cited by 14 publications

(4 citation statements)

References 43 publications

(50 reference statements)

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“…19,152,217 5.4 Photoacoustic-Guided Surgical Navigation PA-guided intervention is a growing research field that is described in several reviews. [218][219][220] Preclinical studies have demonstrated the feasibility of various applications, such as pedicle screw evaluation, 221 catheter-based interventions, 222,223 and liver surgery. 224 In cardiac, catheter-based interventions accurate navigation is essential for diagnosis and effective treatment.…”

Section: Intravascular Photoacoustic Imaging To Identify Vulnerable P...mentioning

confidence: 99%

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Photoacoustic imaging on its way toward clinical utility: a tutorial review focusing on practical application in medicine

2023

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Photoacoustic imaging (PAI) enables the visualization of optical contrast with ultrasonic imaging. It is a field of intense research, with great promise for clinical application. Understanding the principles of PAI is important for engineering research and image interpretation.Aim: In this tutorial review, we lay out the imaging physics, instrumentation requirements, standardization, and some practical examples for (junior) researchers, who have an interest in developing PAI systems and applications for clinical translation or applying PAI in clinical research.Approach: We discuss PAI principles and implementation in a shared context, emphasizing technical solutions that are amenable to broad clinical deployment, considering factors such as robustness, mobility, and cost in addition to image quality and quantification.Results: Photoacoustics, capitalizing on endogenous contrast or administered contrast agents that are approved for human use, yields highly informative images in clinical settings, which can support diagnosis and interventions in the future.Conclusion: PAI offers unique image contrast that has been demonstrated in a broad set of clinical scenarios. The transition of PAI from a "nice-to-have" to a "need-to-have" modality will require dedicated clinical studies that evaluate therapeutic decision-making based on PAI and consideration of the actual value for patients and clinicians, compared with the associated cost.

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Section: Intravascular Photoacoustic Imaging To Identify Vulnerable P...mentioning

confidence: 99%

“…PA-guided intervention is a growing research field that is described in several reviews 218 – 220 Preclinical studies have demonstrated the feasibility of various applications, such as pedicle screw evaluation, 221 catheter-based interventions, 222 , 223 and liver surgery 224 …”

Section: Clinical and Translational Researchmentioning

confidence: 99%

Photoacoustic imaging on its way toward clinical utility: a tutorial review focusing on practical application in medicine

2023

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“…The output of PA thermometer was used as the feed-back controller for photothermal therapy [27] . An integrated photoacoustic guided system was developed for endovenous laser ablation [28] .…”

Section: Introductionmentioning

confidence: 99%

In vivo photothermal therapy monitored by multi-position calibrated photoacoustic thermometer

Peng

Wang

et al. 2023

Photoacoustics

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“…Photoacoustic computed tomography (PACT), a hybrid imaging modality that combines the rich contrast of optical absorption and deep penetration of ultrasound detection, have been widely used for disease diagnosis and surgical guidance [23]- [31]. PACT's capability of deep-tissue functional imaging can be readily used for thrombus factor estimation.When the photons from a pulsed laser are diffused in tissue and absorbed by either endogenous or exogenous chromophores, the absorbed optical energy is completely or partially converted to heat, resulting in transient temperature rise that leads to thermoelastic expansion and pressure rise.…”

Section: Introductionmentioning

confidence: 99%

Deep thrombosis characterization using photoacoustic imaging with intravascular light delivery

Tang

Klippel

et al. 2022

Biomed. Eng. Lett.

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Venous thromboembolism (VTE) is a condition in which blood clots form within the deep veins of the leg or pelvis to cause deep vein thrombosis. The optimal treatment of VTE is determined by thrombus properties such as the age, size, and chemical composition of the blood clots. The thrombus properties can be readily evaluated by using photoacoustic computed tomography (PACT), a hybrid imaging modality that combines the rich contrast of optical imaging and deep penetration of ultrasound imaging. With inherent sensitivity to endogenous chromophores such as hemoglobin, multispectral PACT can provide composition information and oxygenation level in the clots. However, conventional PACT of clots relies on external light illumination, which provides limited penetration depth due to strong optical scattering of intervening tissue. In our study, this depth limitation is overcome by using intravascular light delivery with a thin optical ber. To demonstrate in vitro blood clot characterization, clots with different acuteness and oxygenation levels were placed underneath ten-centimeter-thick chicken breast tissue and imaged using multiple wavelengths. Acoustic frequency analysis was performed on the received PA channel signals, and oxygenation level was estimated using multispectral linear spectral unmixing. The results show that, with intravascular light delivery, clot oxygenation level can be accurately measured, and the clot age can thus be estimated. In addition, we found that retracted and unretracted clots had different acoustic frequency spectrum. While unretracted clots had stronger high frequency components, retracted clots had much higher low frequency components due to densely packed red blood cells. The PACT characterization of the clots was consistent with the histology results and mechanical tests.

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Photoacoustic-guided endovenous laser ablation: Characterization and in vivo canine study

Cited by 14 publications

References 43 publications

Photoacoustic imaging on its way toward clinical utility: a tutorial review focusing on practical application in medicine

Photoacoustic imaging on its way toward clinical utility: a tutorial review focusing on practical application in medicine

In vivo photothermal therapy monitored by multi-position calibrated photoacoustic thermometer

Deep thrombosis characterization using photoacoustic imaging with intravascular light delivery

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