“…During admission, blood pressure and heart rate measurements using a Dinamap Ò (GE Healthcare, Chalfont St. Giles, UK) blood pressure monitor using the oscillometric method and 12-lead digital ECG recordings were taken in the supine position, after resting for at least 10 minutes, at the following times: (i) day -1 (the day prior to first dosing) -time 0 (24 hours before first dosing) and 1, 2, 3, 4, 6, 8, 10, 12, and 16 hours after; (ii) day 1 (day of first dosing) -pre-dose and 1, 2, 3, 4, 6, 8, 10, 12, and 16 hours post-dose; (iii) from day 2 to day 9 -pre-dose and 2 hours post-dose; and (iv) day 10 (day of last dosing) -pre-dose and 1, 2, 3, 4,6,8,10,12,16,24,48, and 72 hours post-dose. Digital ECGs were performed in triplicate (with an interval of 5 minutes, with a difference of at least 1 minute between each of the three recordings).…”