“…Amide bond is present in about 25% of pharmaceutical drugs, and amide bond formation is one of the most performed reactions in synthesizing pharmaceuticals . Amides are reactive partners in a variety of synthetic transformations because of their coordination with metal complexes, conformational diversity, and high polarity . Amide bond acts as a directing group in C–H functionalization for olefination, arylation, alkylation, cyanation, borylation, and silylation .…”