Real time monitoring of aminothiol level in blood using a near-infrared dye assisted deep tissue fluorescence and photoacoustic bimodal imaging

Anees, Palapuravan; Joseph, James; Sreejith, Sivaramapanicker; Menon, Nishanth Venugopal; Kang, Yuejun; Yu, Sidney; Ajayaghosh, Ayyappanpillai; Zhao, Yanli

doi:10.1039/c5sc04986e

Cited by 64 publications

(44 citation statements)

References 66 publications

(15 reference statements)

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“…8 However, in the NIR region (650–900 nm), the absorption coefficient of tissue is greatly suppressed to a minimum level, thus it drastically reduces the noise from the auto-fluorescence and increases tissue penetration. 8 Therefore, developing GFR agents in the NIR window is crucial for non-invasive transcutaneous assessment of kidney function.…”

Section: Introductionmentioning

confidence: 99%

Zwitterionic near infrared fluorescent agents for noninvasive real-time transcutaneous assessment of kidney function

et al. 2017

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Section: Introductionmentioning

confidence: 99%

Zwitterionic near infrared fluorescent agents for noninvasive real-time transcutaneous assessment of kidney function

et al. 2017

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“…Currently, according to noninvasive, real‐time, and high‐resolution modalities for the disease detection, optical imaging approaches are emerging as ideal technology . Molecular information of the disease anatomical structure and even the disease metabolism can be obtained from the optical signals .…”

Section: Introductionmentioning

confidence: 99%

Polyacrylamide Nanoparticles with Visible and Near-Infrared Autofluorescence

Xie

Zhang

et al. 2017

Part. Part. Syst. Charact.

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Nowadays, self‐fluorescent materials such as quantum dots are widely studied and applied in biomedical field. However, the biggest obstacle is biocompatibility. Here, a novel autofluorescent nanoparticle is constructed by crosslinking polyacrylamide nanoparticles (PAANPs) that contain ε‐poly‐l‐lysine with glutaraldehyde (named fPAANPs). The nanoparticle has a mean size of about 16 nm, a zeta potential of about +16 mV, and strong visible and near‐infrared autofluorescence. The nanoparticle can be efficiently internalized into cells with high biocompatibility, the LC50 of which in RAW264.7, HepG2, and Hepa1‐6 cells is 6, 9, and 7.5 mg mL−1, respectively. The nanoparticle shows no visible impact on the mice vitality even at a high intravenously administered dose (126 mg kg−1). The autofluorescence of fPAANPs shows high stability, persistence, allowing long‐term dynamic imaging for 25 d in subcutaneous injections and 18 d in xenograft tumors in mice. The nanoparticle thus provides a self‐traceable nanomaterial that can be exploited as drug carrier and potential photodynamic therapy photosensitizer.

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“…The fixation of CO 2 as carbonates or bicarbonatesc an be followed by 13 CNMR spectroscopy ( Figure 2). The 13 CNMR spectrum recorded in CD 3 CN after purging with CO 2 revealed a new signal at d = 171.3 ppm, which corresponded to the resonance of the carbonatei on ( Figure 2b).…”

Section: Nmr Spectroscopys Tudiesmentioning

confidence: 99%

“…As chematic illustration of the purging setup is shown in Figure S2 in the Supporting Information. 13 CNMR spectroscopy experiments for establishing carbonate formation were performed by directly bubbling CO 2 gas continuously into as olution of Sq-Zn 2 + in CD 3 CN containing approximately 1% water in aW ilmad NMR tube (5 mm in diameter,w ith ap recision limit up to 500 MHz) until the visual color changed from violet to blue. The sample was then subjected to NMR spectroscopy by recording 61 000 scans.…”

Section: Co 2 Sensing Experimentsmentioning

confidence: 99%

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An Unsymmetrical Squaraine‐Dye‐Based Chemical Platform for Multiple Analyte Recognition

Philips

Ghosh

Sudheesh

et al. 2017

Chemistry A European J

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The design of fluorescent molecular platforms capable of responding to multiple analytes is a topic of great interest. Herein, the use of a Zn -complexed unsymmetrical squaraine dye, Sq-Zn , as a chemical platform for recognizing structurally distinct analytes is reported. The squaraine ring is substituted on one side with a dipicolylamine unit, which acts as the metal ion receptor, whereas the other part of the molecule carries a dibutylaniline moiety, which is an electron donor. The molecular system is unique because it can respond specifically to different types of analytes, namely, atmospheric carbon dioxide, cyclic phosphates, and picric acid. Moreover, the interaction of these analytes can be monitored colorimetrically and fluorimetrically, which favors both qualitative and quantitative analyses. The distinct response towards cyclic and linear phosphates, as well as the selective response towards picric acid, among the various nitroaromatic compounds was achieved with sensitivity at the ppm level. The flexible coordination offered by Zn plays a significant role in the discrimination of these analytes with high specificity. Dye Sq-Zn introduced herein is a single-molecule construct that can be used for the selective and sensitive response towards analytes of environmental and biological relevance.

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Real time monitoring of aminothiol level in blood using a near-infrared dye assisted deep tissue fluorescence and photoacoustic bimodal imaging

Abstract: Real time monitoring of blood aminothiol level by a near-IR dye assisted fluorescence–photoacoustic bimodal imaging is reported.

Cited by 64 publications

References 66 publications

Zwitterionic near infrared fluorescent agents for noninvasive real-time transcutaneous assessment of kidney function

Zwitterionic near infrared fluorescent agents for noninvasive real-time transcutaneous assessment of kidney function

Polyacrylamide Nanoparticles with Visible and Near-Infrared Autofluorescence

An Unsymmetrical Squaraine‐Dye‐Based Chemical Platform for Multiple Analyte Recognition

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