Real-time in vivo virtual histology of colorectal lesions when using the endocytoscopy system

Sasajima, Keita; Kudo, Shin‐ei; Inoue, Haruhiro; Takeuchi, Takahito; Kashida, Hiroshi; Hidaka, Eiji; Kawachi, Hiroshi; Sakashita, Masanori; Tanaka, Junichi; Shiokawa, Akira

doi:10.1016/j.gie.2006.01.021

Cited by 138 publications

(117 citation statements)

References 8 publications

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“…This device can facilitate the differentiation of neoplastic and non-neoplastic lesions, and it can also guide the observations of celiac disease, amebic colitis, serrated polyps, and rectal carcinoids [7][8][9][10][11][12][13][14] . Furthermore, a correlation between EC classification and paired histological sample findings in UC patients has been reported [15] .…”

Section: Introductionmentioning

confidence: 99%

Endocytoscopic narrow-band imaging efficiency for evaluation of inflammatory activity in ulcerative colitis

Maeda¹,

Ohtsuka²,

Kudo³

et al. 2015

WJG

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AIM:To assess the efficacy of endocytoscopic narrowband imaging (EC-NBI) for evaluating the severity of inflammation in ulcerative colitis (UC). METHODS:This retrospective study was conducted at a single tertiary care referral center. We included UC patients who underwent colonoscopy with endocytoscopy from July 2010 to December 2013. EC-NBI was performed, and the images were evaluated by assessing visibility, increased vascularization, and the increased calibers of capillaries and were classified as Obscure, Visible or Dilated. Obscure was indicative of inactive disease, while Visible and Dilated were indicative of acute inflammation. This study received Institutional Review Board approval. The primary outcome measures included the diagnostic ability of EC-NBI to distinguish between active and inactive UC on the basis of histological activity. The conventional endoscopic images were classified according to the Mayo endoscopic score. A score of 0 or 1 indicated inactive disease, whereas a score of 2 indicated active disease. RESULTS:Fifty-two patients were enrolled. There was a strong correlation between the EC-NBI findings and the histological assessment (r = 0.871, P < 0.01).The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of EC-NBI for diagnosing acute inflammation were 84.0%, 100%, 87.1%, 100%, and 92.3%, respectively, while those for the Mayo endoscopic score were 100%, 40.7%, and accuracy (P < 0.001, P = 0.001 and P = 0.047, respectively). CONCLUSION:The EC-NBI finding of capillaries in the rectal mucosa was strongly correlated with histological inflammation and aided in the differential diagnosis between active and inactive UC.

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Section: Introductionmentioning

confidence: 99%

Endocytoscopic narrow-band imaging efficiency for evaluation of inflammatory activity in ulcerative colitis

Maeda¹,

Ohtsuka²,

Kudo³

et al. 2015

WJG

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“…Two devices are currently available that allow in vivo microscopic inspection of the microstructural mucosal features of the gastrointestinal tract: confocal laser endomicroscopy (CLE) (Pentax, Tokyo, Japan, and Mauna Kea Technologies, Paris, France) [1][2][3][4][5][6] and an endocytoscopy system (ECS) with an ultra-magnification light microscopy device (Olympus Medical Systems, Tokyo, Japan) [1,[7][8][9][10]. There are two types of each device, probe-based and integrated-scope types [6,11].…”

Section: Introductionmentioning

confidence: 99%

Correlation between endocytoscopy and conventional histopathology in microstructural features of ulcerative colitis

et al. 2011

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“…For endoscopy, ultrahigh magnification endoscopes have been developed ("Endocytoscopy") that deliver high resolution images of the uppermost epithelial layer of the gastrointestinal tract. With different staining techniques, in vivo microscopy of superficial cells becomes possible [10][11][12]. Confocal laser endomicroscopy (CLE) is substantially different.…”

Section: Technique Of Confocal Endomicroscopymentioning

confidence: 99%

Confocal Laser Endomicroscopy: Applications in Clinical and Translational Science—A Comprehensive Review

Goetz

2012

ISRN Pathology

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Confocal laser endomicroscopy (CLE) is a novel tool in the endoscopist's armamentarium. It allows on-site histological information. The ability of gastroenterologists to interpret such microscopic information has been demonstrated in multiple studies from the upper and lower gastrointestinal tract. Recently, the field of application has expanded to provide hepatobiliary and intra-abdominal CLE imaging. CLE allows "smart," targeted biopsies and is able to guide endoscopic interventions. But CLE is also translational in its approach and permits functional imaging that significantly impacts on our understanding of gastrointestinal diseases. Molecular imaging with CLE allows detection and characterization of lesions and may even be used for prediction of response to targeted therapy. This paper provides a comprehensive review over current applications of CLE in clinical applications and translational science.

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Real-time in vivo virtual histology of colorectal lesions when using the endocytoscopy system

Cited by 138 publications

References 8 publications

Endocytoscopic narrow-band imaging efficiency for evaluation of inflammatory activity in ulcerative colitis

Endocytoscopic narrow-band imaging efficiency for evaluation of inflammatory activity in ulcerative colitis

Correlation between endocytoscopy and conventional histopathology in microstructural features of ulcerative colitis

Confocal Laser Endomicroscopy: Applications in Clinical and Translational Science—A Comprehensive Review

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