Correlation between endocytoscopy and conventional histopathology in microstructural features of ulcerative colitis

Bessho, Rieko; Kanai, Takanori; Hosoe, Naoki; Kobayashi, Taku; Takayama, Tetsuro; Inoue, Nagamu; Mukai, Makio; Ogata, Haruhiko; Hibi, Toshifumi

doi:10.1007/s00535-011-0439-1

Cited by 59 publications

(57 citation statements)

References 14 publications

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“…Employing an approach similar to that used in the present study, Bessho et al [15] have shown the benefits of classifying the histological activity of UC using EC. In their report, the shape and distance of the crypt were also assessed, and an excellent correlation was revealed between EC and histological diagnosis.…”

Section: Discussionmentioning

confidence: 99%

“…However, their study had some limitations because the EC observations required pretreatment with methylene blue or toluidine blue staining. The additional time required for EC observation was reported to be approximately 20 min in one area [15] . Therefore, a more practical procedure for assessing the histological activity of UC is necessary.…”

Section: Discussionmentioning

confidence: 99%

“…This device can facilitate the differentiation of neoplastic and non-neoplastic lesions, and it can also guide the observations of celiac disease, amebic colitis, serrated polyps, and rectal carcinoids [7][8][9][10][11][12][13][14] . Furthermore, a correlation between EC classification and paired histological sample findings in UC patients has been reported [15] . Narrow-band imaging (NBI; Olympus Medical Systems) is a technique that uses spectral narrow-band optical filters instead of the full spectrum of white light.…”

Section: Introductionmentioning

confidence: 99%

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Endocytoscopic narrow-band imaging efficiency for evaluation of inflammatory activity in ulcerative colitis

Maeda¹,

Ohtsuka²,

Kudo³

et al. 2015

WJG

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AIM:To assess the efficacy of endocytoscopic narrowband imaging (EC-NBI) for evaluating the severity of inflammation in ulcerative colitis (UC). METHODS:This retrospective study was conducted at a single tertiary care referral center. We included UC patients who underwent colonoscopy with endocytoscopy from July 2010 to December 2013. EC-NBI was performed, and the images were evaluated by assessing visibility, increased vascularization, and the increased calibers of capillaries and were classified as Obscure, Visible or Dilated. Obscure was indicative of inactive disease, while Visible and Dilated were indicative of acute inflammation. This study received Institutional Review Board approval. The primary outcome measures included the diagnostic ability of EC-NBI to distinguish between active and inactive UC on the basis of histological activity. The conventional endoscopic images were classified according to the Mayo endoscopic score. A score of 0 or 1 indicated inactive disease, whereas a score of 2 indicated active disease. RESULTS:Fifty-two patients were enrolled. There was a strong correlation between the EC-NBI findings and the histological assessment (r = 0.871, P < 0.01).The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of EC-NBI for diagnosing acute inflammation were 84.0%, 100%, 87.1%, 100%, and 92.3%, respectively, while those for the Mayo endoscopic score were 100%, 40.7%, and accuracy (P < 0.001, P = 0.001 and P = 0.047, respectively). CONCLUSION:The EC-NBI finding of capillaries in the rectal mucosa was strongly correlated with histological inflammation and aided in the differential diagnosis between active and inactive UC.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Endocytoscopic narrow-band imaging efficiency for evaluation of inflammatory activity in ulcerative colitis

Maeda¹,

Ohtsuka²,

Kudo³

et al. 2015

WJG

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“…Bessho et al proposed a scoring system based on the sum of graduated criteria including shave of the crypts graduated (0-3), distance between crypts (0-2) and the visibility of superficial microvessels (0-1). The Endocytoscopy System Score (ECSS) shows a strong correlation with histology and good agreement for distinguishing between active and inactive US [35]. These results were confirmed by Maeda et al who evaluated the performance of virtual chromoendoscopy coupled with endocytoscopy (CE-NBI) compared to standard endoscopy in UC [36].…”

Section: Journal Of Clinical Gastroenterology and Hepatology Issn 257mentioning

confidence: 73%

Assessment of Mucosal Healing in Inflammatory Bowel Disease

Auzoux¹,

Boschetti²,

Lahlou³

et al. 2017

J Clin Gastroenterol Hepatol

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In recent decades, the advent of biological therapy has changed the treatment of inflammatory bowel disease (IBD) and has opened new therapeutic endpoints such as mucosal healing (MH). MH incorporated with clinical remission presents a new concept: deep remission, which correlates with a decrease in hospitalization and surgery and improvement in the patient's quality of life. Several techniques can be used to assess mucosal healing such as endoscopy which remains the gold standard. But considerable variations may exist in the interpretation of the definition of mucosal healing which may also be histological or evaluated by radiological or biological methods. Thus, it is important to study mucosal inflammation by endoscopic scores and by new, more sensitive techniques such as videocapsule endoscopy (VCE), magnetic resonance enterography (MRE), chromoendoscopy and confocal laser endomicroscopy (CLE). Biomarkers, such as fecal calprotectin (FC) were also studied in the evaluation of MH and showed positive results. These methods are currently the subject of validation studies.

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“…Previously, we reported that EC exceeds the diagnostic ability of both PIT and NBI-ME. [13][14][15][16] During EC, the ultra-magnified microvessels of the lesion can be observed, and they have been used to evaluate the inflammation grade of ulcerative colitis, 17 but there is little literature describing ultra-magnified microvessels in conjunction with colorectal neoplasm diagnoses. This pilot study investigated the ultra-magnified microvessel findings of colorectal lesions and compared their diagnostic ability with that of other modalities (eg, NBI-ME, PIT, and EC).…”

mentioning

confidence: 99%

Endocytoscopic microvasculature evaluation is a reliable new diagnostic method for colorectal lesions (with video)

Kudo

Misawa

Wada

et al. 2015

Gastrointestinal Endoscopy

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Correlation between endocytoscopy and conventional histopathology in microstructural features of ulcerative colitis

Abstract: Our novel ECSS has good predictive value for the histopathological activity of UC.

Cited by 59 publications

References 14 publications

Endocytoscopic narrow-band imaging efficiency for evaluation of inflammatory activity in ulcerative colitis

Endocytoscopic narrow-band imaging efficiency for evaluation of inflammatory activity in ulcerative colitis

Assessment of Mucosal Healing in Inflammatory Bowel Disease

Endocytoscopic microvasculature evaluation is a reliable new diagnostic method for colorectal lesions (with video)

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