Real-time in-die compaction monitoring of dry-coated tablets

Liu, Jingfei; Stephens, James D.; Kowalczyk, Brian R.; Cetinkaya, Çetin

doi:10.1016/j.ijpharm.2011.05.029

Cited by 18 publications

(4 citation statements)

References 17 publications

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“…In the case of SHC, the small size of the molecule and its decomposition in CO2, may keep the chitosan chains closer during gelation, allowing formation of a stronger network. Its combination with either phosphate buffer or BGP enables to reach both good mechanical properties and rapid gelation kinetics [22], making them advantageous compared to previously developed CH physical thermogels made with BGP alone, sodium hydrogen carbonate [55] dibasic sodium phosphate [56] or ammonium hydrogen phosphate [57]. The absence of chemical initiators, crosslinkers, radiation and high temperature during gelation is favorable for cell survival and may facilitate clinical transfer, compared to many other hydrogel systems [58][59][60][61].…”

Section: Discussionmentioning

confidence: 99%

Injectable Chitosan Hydrogels with Enhanced Mechanical Properties for Nucleus Pulposus Regeneration

Alinejad

Adoungotchodo

Grant

et al. 2019

Tissue Engineering Part A

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Section: Discussionmentioning

confidence: 99%

Injectable Chitosan Hydrogels with Enhanced Mechanical Properties for Nucleus Pulposus Regeneration

Alinejad

Adoungotchodo

Grant

et al. 2019

Tissue Engineering Part A

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“…the accurate estimation of the effective values of the strain and hence, the Young's modulus. Several methodologies including ultrasonic techniques have been used to obtain the effective elastic moduli of pharmaceutical tablets (Akseli and Cetinkaya, 2008;Akseli et al, 2010;Bassam et al, 1990;Hancock, 2000;Ketolainen et al, 1995;Liu and Cetinkaya, 2010;Liu et al, 2011;Porion et al, 2010;Roberts et al, 1991). Since the Young's modulus has an explicit dependence on the porosity, Mazel et al, 2012, andPalomäki et al, 2015, have devised an experimental technique to measure the porosity dependent Young's modulus of pharmaceutical compacts.…”

Section: Link To Mechanical Propertiesmentioning

confidence: 99%

Characterisation of pore structures of pharmaceutical tablets: A review

Markl

Strobel

Schlossnikl

et al. 2018

International Journal of Pharmaceutics

104

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Traditionally, the development of a new solid dosage form is formulation-driven and less focus is put on the design of a specific microstructure for the drug delivery system. However, the compaction process particularly impacts the microstructure, or more precisely, the pore architecture in a pharmaceutical tablet. Besides the formulation, the pore structure is a major contributor to the overall performance of oral solid dosage forms as it directly affects the liquid uptake rate, which is the very first step of the dissolution process. In future, additive manufacturing is a potential game changer to design the inner structures and realise a tailor-made pore structure. In pharmaceutical development the pore structure is most commonly only described by the total porosity of the tablet matrix. Yet it is of great importance to consider other parameters to fully resolve the interplay between microstructure and dosage form performance. Specifically, tortuosity, connectivity, as well as pore shape, size and orientation all impact the flow paths and play an important role in describing the fluid flow in a pharmaceutical tablet. This review presents the key properties of the pore structures in solid dosage forms and it discusses how to measure these properties. In particular, the principles, advantages and limitations of helium pycnometry, mercury porosimetry, terahertz time-domain spectroscopy, nuclear magnetic resonance and X-ray computed microtomography are discussed.

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“…The dwell time of a typical commercial compaction press is on a millisecond scale ranging from ~5ms to over 80 ms while the acoustic pulse method of acquiring the Time-of-Flight (ToF) is on the microsecond (μs) scale Leskinen et al, 2010) thus allowing many acquisitions during a single compaction event (real-time in-die monitoring). It has been previously established that, by utilizing a non-destructive off-line acoustic pulse-echo method Liu et al, 2011;Liu and Cetinkaya, 2010;Smith et al, 2011), the mechanical properties of tablets with complex geometries such as dry-coated and layered tablets can be characterized. It was also shown that not only can in-die measurements be made, but they can be done wirelessly and also in-line (out-of-die post compaction), resulting in comparative differentiation in solid dosage mechanical properties Stephens et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Correlation of solid dosage porosity and tensile strength with acoustically extracted mechanical properties

Mack

Cleland³

et al. 2018

International Journal of Pharmaceutics

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Currently, the compressed tablet and its oral administration is the most popular drug delivery modality in medicine. The accurate porosity and tensile strength characterization of a tablet design is vital for predicting its performance such as disintegration, dissolution, and drug-release efficiency upon administration as well as ensuring its mechanical integrity. In current work, a non-destructive contact ultrasonic approach and an associated testing procedure are presented and employed to quantify and relate the acoustically extracted mechanical properties of pharmaceutical compacts to direct porosity and tensile strength measurements. Based on a comprehensive set of experimental data, it is demonstrated how strongly the acoustic wave propagation is modulated and correlated to the tablet porosity and tensile strength of a compact made using spray-dried lactose and microcrystalline cellulose with varying mixture ratios. The effect of mixing ratio on the porosity and tensile strength on the resulting compacts is quantified and, with the acoustic experimental data, mixing ratio is related to the compact ultrasonic characteristics. The ultrasonic techniques provide a rapid, non-destructive means for evaluating compacts in formulation development and manufacturing. The presented approach and data could find critical applications in continuous tablet manufacturing, its real-time quality monitoring, as well as minimizing batch-to-batch quality variations.

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Real-time in-die compaction monitoring of dry-coated tablets

Cited by 18 publications

References 17 publications

Injectable Chitosan Hydrogels with Enhanced Mechanical Properties for Nucleus Pulposus Regeneration

Injectable Chitosan Hydrogels with Enhanced Mechanical Properties for Nucleus Pulposus Regeneration

Characterisation of pore structures of pharmaceutical tablets: A review

Correlation of solid dosage porosity and tensile strength with acoustically extracted mechanical properties

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