Real-Time Elastography in the Diagnosis of Patients Suspected of Having Prostate Cancer: A Meta-analysis

Zhang, Binglan; Ma, Xuelei; Zhan, Wenli; Zhu, Fengqin; Li, Minmin; Huang, Juan; Li, Yanyan; Li, Xue; Liu, Lei; Wei, Yuquan

doi:10.1016/j.ultrasmedbio.2014.02.020

Cited by 48 publications

(38 citation statements)

References 30 publications

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“…Deeks’ funnel plots showed no significant publication bias, and according to the QUADAS-2 questionnaire, the 7 studies were of high quality. Our results showed that SWE had a pooled sensitivity of 84.4% and specificity of 86.0% for the detection of PCa; these values are both higher than those obtained for traditional TRUS 32 and real-time elastography for the diagnosis of patients with suspected PCa 37 . The AUC (0.91) and DOR (33.069) further indicated perfect overall accuracy.…”

Section: Discussionmentioning

confidence: 49%

Accuracy of shear wave elastography for the diagnosis of prostate cancer: A meta-analysis

Liang

Wang

et al. 2017

Sci Rep

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Many studies have established the high diagnostic accuracy of shear wave elastography (SWE) for the detection of prostate cancer (PCa); however, its utility remains a subject of debate. This meta-analysis sought to appraise the overall accuracy of SWE for the detection of PCa. A literature search of the PubMed, Embase, Cochrane Library, Web of Science and CNKI (China National Knowledge Infrastructure) databases was conducted. In all of the included studies, the diagnostic accuracy of SWE was compared with that of histopathology, which was used as a standard. Data were pooled, and the sensitivity, specificity, area under the curve (AUC), positive likelihood ratio (PLR), negative likelihood ratio (NLR), and diagnostic odds ratio (DOR) were calculated to estimate the accuracy of SWE. The pooled sensitivity and specificity for the diagnosis of PCa by SWE were 0.844 (95% confidence interval: 0.696–0.927) and 0.860 (0.792–0.908), respectively. The AUC was 0.91 (0.89–0.94), the PLR was 6.017 (3.674–9.853), and the NLR was 0.182 (0.085–0.389). The DOR was 33.069 (10.222–106.982). Thus, SWE exhibited high accuracy for the detection of PCa using histopathology as a diagnostic standard. Moreover, SWE may reduce the number of core biopsies needed.

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Section: Discussionmentioning

confidence: 49%

Accuracy of shear wave elastography for the diagnosis of prostate cancer: A meta-analysis

Liang

Wang

et al. 2017

Sci Rep

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“…Zhang et al performed a meta-analysis including SE data from 7 studies (508 patients) compared to histopathology following radical prostatectomy, showing a pooled sensitivity of 72% and specificity of 76% for prostate cancer detection (Table 3, 125). In another study by Brock et al in 229 patients with biopsy-proven prostate cancer using grey-scale ultrasonography and SE, the sensitivity and specificity of SE in detecting prostate cancer was 51% and 72% respectively, compared to 18% and 90% respectively for conventional grey-scale ultrasonography.…”

Section: Clinical Applications Of Ultrasound Elastographymentioning

confidence: 99%

Ultrasound Elastography: Review of Techniques and Clinical Applications

et al. 2017

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Elastography-based imaging techniques have received substantial attention in recent years for non-invasive assessment of tissue mechanical properties. These techniques take advantage of changed soft tissue elasticity in various pathologies to yield qualitative and quantitative information that can be used for diagnostic purposes. Measurements are acquired in specialized imaging modes that can detect tissue stiffness in response to an applied mechanical force (compression or shear wave). Ultrasound-based methods are of particular interest due to its many inherent advantages, such as wide availability including at the bedside and relatively low cost. Several ultrasound elastography techniques using different excitation methods have been developed. In general, these can be classified into strain imaging methods that use internal or external compression stimuli, and shear wave imaging that use ultrasound-generated traveling shear wave stimuli. While ultrasound elastography has shown promising results for non-invasive assessment of liver fibrosis, new applications in breast, thyroid, prostate, kidney and lymph node imaging are emerging.Here, we review the basic principles, foundation physics, and limitations of ultrasound elastography and summarize its current clinical use and ongoing developments in various clinical applications.

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“…In a metaanalysis by Aboumarzouk et al (35), the sensitivity and specificity of SE were in the range of 71%-82% and 60%-95%, respectively, with radical prostatectomy specimens as the reference standard. A more recent metaanalysis by Zhang et al (36) comparing SE with radical prostatectomy specimens reported a pooled sensitivity of 72% and specificity of 76%. Benign conditions such as prostatitis, fibrosis, and atrophy may demonstrate decreased elasticity, resulting in false-positive results.…”

Section: Ultrasound Elastographymentioning

confidence: 99%

Utility of Ultrasound in the Diagnosis, Treatment, and Follow-up of Prostate Cancer: State of the Art

2016

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Prostate cancer screening currently consists of serum prostatespecific antigen and digital rectal examination, followed by transrectal ultrasound-guided biopsy for diagnostic confirmation. Although the current paradigm of prostate cancer screening has led to a decrease in advanced disease and cancer-related mortality, these techniques have limitations in terms of sensitivity and specificity, resulting in missed cancers that are clinically significant and the overdetection of clinically insignificant cancers. New imaging techniques and technologies are required to improve the detection of prostate cancer. This article summarizes the use of novel ultrasound techniques and technologies in the detection, biopsy, and treatment of prostate cancer.

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Real-Time Elastography in the Diagnosis of Patients Suspected of Having Prostate Cancer: A Meta-analysis

Cited by 48 publications

References 30 publications

Accuracy of shear wave elastography for the diagnosis of prostate cancer: A meta-analysis

Accuracy of shear wave elastography for the diagnosis of prostate cancer: A meta-analysis

Ultrasound Elastography: Review of Techniques and Clinical Applications

Utility of Ultrasound in the Diagnosis, Treatment, and Follow-up of Prostate Cancer: State of the Art

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