Reaktive Arthritis nach Katzenbiß: eine seltene Manifestation der Katzenkratzkrankheit - Kasuistik und Übersicht

Jendro, M. C.; Weber, Giovanna; Brabant, T.; Zeidler, Henning; Wollenhaupt, J.

doi:10.1007/s003930050074

Cited by 8 publications

(3 citation statements)

References 7 publications

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“…Also, consistent with previous study findings ( 15 ), the PCRs depicted in Figure 2 illustrate an increased likelihood of positivity if blood, serum, and enrichment blood cultures are independently tested. According to these and previous results ( 7 , 18 , 31 , 32 ), a subset of Bartonella spp.–bacteremic patients could be anergic and might not produce a detectable IFA response, or alternatively, the substantial antigenic variation among various Bartonella strains might result in false-negative IFA assay results for some patients. In a study on Bartonella serology conducted by the Centers for Disease Control and Prevention, IFA cross-reactivity among Bartonella species occurred in 94% of patients with suspected cat-scratch disease ( 33 ).…”

Section: Discussionsupporting

confidence: 57%

“…Among these, bartonellae of 14 species or subspecies have been implicated in zoonotic diseases ( 5 , 6 ), including cat-scratch disease, which is caused by B. henselae transmission during a cat bite or scratch and characterized by acute onset of self-limiting fever and regional lymphadenopathy ( 7 – 9 ). Recent observations, however, are causing a paradigm shift from the assumption that infection with a Bartonella sp.…”

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confidence: 99%

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Bartonellaspp. Bacteremia and Rheumatic Symptoms in Patients from Lyme Disease–endemic Region

Maggi¹,

Mozayeni²,

Pultorak³

et al. 2012

Emerg. Infect. Dis.

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Section: Discussionsupporting

confidence: 57%

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confidence: 99%

Bartonellaspp. Bacteremia and Rheumatic Symptoms in Patients from Lyme Disease–endemic Region

Maggi¹,

Mozayeni²,

Pultorak³

et al. 2012

Emerg. Infect. Dis.

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“…A role for cat saliva and for cat bites in the transmission of B. henselae or B. quintana has been suggested but never been fully investigated [22, 52, 70]. Finally, no work has been conducted to determine the sequential dispersion of B. henselae within cat fleas except to document the presence of B. henselae in the lumen of the flea gut.…”

Section: Adaptation Of Bartonella Species To the Arthropod Vectormentioning

confidence: 99%

Ecological fitness and strategies of adaptation ofBartonellaspecies to their hosts and vectors

et al. 2009

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Bartonella spp. are facultative intracellular bacteria that cause characteristic host-restricted hemotropic infections in mammals and are typically transmitted by blood-sucking arthropods. In the mammalian reservoir, these bacteria initially infect a yet unrecognized primary niche, which seeds organisms into the blood stream leading to the establishment of a long-lasting intra-erythrocytic bacteremia as the hall-mark of infection. Bacterial type IV secretion systems, which are supra-molecular transporters ancestrally related to bacterial conjugation systems, represent crucial pathogenicity factors that have contributed to a radial expansion of the Bartonella lineage in nature by facilitating adaptation to unique mammalian hosts. On the molecular level, the type IV secretion system VirB/VirD4 is known to translocate a cocktail of different effector proteins into host cells, which subvert multiple cellular functions to the benefit of the infecting pathogen. Furthermore, bacterial adhesins mediate a critical, early step in the pathogenesis of the bartonellae by binding to extracellular matrix components of host cells, which leads to firm bacterial adhesion to the cell surface as a prerequisite for the efficient translocation of type IV secretion effector proteins. The best-studied adhesins in bartonellae are the orthologous trimeric autotransporter adhesins, BadA in Bartonella henselae and the Vomp family in Bartonella quintana. Genetic diversity and strain variability also appear to enhance the ability of bartonellae to invade not only specific reservoir hosts, but also accidental hosts, as shown for B. henselae. Bartonellae have been identified in many different blood-sucking arthropods, in which they are typically found to cause extracellular infections of the mid-gut epithelium. Adaptation to specific vectors and reservoirs seems to be a common strategy of bartonellae for transmission and host diversity. However, knowledge regarding arthropod specificity/restriction, the mode of transmission, and the bacterial factors involved in arthropod infection and transmission is still limited.

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Cat‐scratch disease–associated arthropathy

Giladi¹,

Maman²,

Paran³

et al. 2005

Arthritis & Rheumatism

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Objective. To characterize the articular manifestations of cat-scratch disease (CSD) and to evaluate the long-term clinical outcome of those manifestations.Methods. A community-and hospital-based surveillance study of CSD was conducted in Israel between 1991 and 2002. CSD was defined as present in a patient when a compatible clinical syndrome and a positive confirmatory finding of Bartonella henselae (by serology and/or polymerase chain reaction) were identified. CSD patients with arthropathy (arthritis/arthralgia) that limited or precluded usual activities of daily living constituted the study group. Patients were followed up until >6 weeks after resolution of symptoms, or if symptoms persisted, for >12 months. CSD patients without arthropathy served as controls.Results. Among 841 CSD patients, 24 (2.9%) had rheumatoid factor-negative arthropathy that was often severe and disabling. Both univariate and multivariate analyses identified female sex (67% of arthropathy patients versus 40% of controls; relative risk [RR] 2.5, P ‫؍‬ 0.047), age older than 20 years (100% of arthropathy patients versus 43% of controls; RR 4.9, P ‫؍‬ 0.001), and erythema nodosum (21% of arthropathy patients versus 2% of controls; RR 7.9, P ‫؍‬ 0.001) as variables significantly associated with arthropathy. Knee, wrist, ankle, and elbow joints were most frequently affected. Ten patients (42%) had severe arthropathy in the weight-bearing joints, which substantially limited their ability to walk, and 4 of these patients were hospitalized. All of the patients had regional lymphadenopathy, 37.5% had nocturnal joint pain, and 25% had morning stiffness. Nineteen patients (79.2%) recovered after a median duration of 6 weeks (range 1-24 weeks), whereas 5 patients (20.8%) developed chronic disease persisting 16-53 months (median 30 months) after the onset of arthropathy.Conclusion. This is the first comprehensive study of arthropathy in CSD. CSD-associated arthropathy is an uncommon syndrome affecting mostly young and middle-age women. It is often severe and disabling, and may take a chronic course.Cat-scratch disease (CSD) is a common zoonosis caused principally by Bartonella henselae. Typical CSD, which occurs in ϳ90% of CSD cases, is characterized by subacute regional lymphadenitis that is often associated with systemic symptoms such as fever and malaise. When CSD affects other organs, as occurs in ϳ10% of patients, the disease is designated atypical CSD. Atypical CSD includes Parinaud's oculoglandular syndrome, neuroretinitis, encephalitis, peripheral neuritis, granulomatous hepatitis, and/or splenitis, osteomyelitis, erythema nodosum, pneumonitis, and prolonged fever of unknown origin (1). Over the last decade we have occasionally observed CSD patients with severe, protracted, and often disabling arthropathy. A literature search identified only a few CSD patients with arthropathy having been reported since 1950 (2-7), when "la maladie des griffes de chat" was first defined as a syndrome (8), raising doubts regarding whether arthropathy is a r...

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Reaktive Arthritis nach Katzenbiß: eine seltene Manifestation der Katzenkratzkrankheit - Kasuistik und Übersicht

Cited by 8 publications

References 7 publications

Bartonellaspp. Bacteremia and Rheumatic Symptoms in Patients from Lyme Disease–endemic Region

Bartonellaspp. Bacteremia and Rheumatic Symptoms in Patients from Lyme Disease–endemic Region

Ecological fitness and strategies of adaptation ofBartonellaspecies to their hosts and vectors

Cat‐scratch disease–associated arthropathy

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