Readability and quality assessment of internet‐based patient education materials related to laryngeal cancer

Narwani, Vishal; Nalamada, Keerthana; Lee, Michael; Kothari, Prasad; Lakhani, Raj

doi:10.1002/hed.23939

Cited by 38 publications

(44 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Conversely, more effort was made to describe the effects and benefits of treatment. This is a fairly known problem with online cancer information [20][21][22][37][38][39] which makes reporting one-sided and thus withholds important information for treatment decision-making. However, this may not apply to all websites considered.…”

Section: Principal Results and Comparison With Prior Workmentioning

confidence: 99%

“…It has become common practice to review most visible online cancer information on therapy using scientifically validated tools [20][21][22][23][24] to explore what shortcomings exist and what should be taken into account when using the information. Online treatment information is used by patients to support their treatment decision-making [25].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Exploring the Most Visible German Websites on Melanoma Immunotherapy: A Web-Based Analysis

et al. 2018

View full text Add to dashboard Cite

show abstract

Section: Principal Results and Comparison With Prior Workmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Exploring the Most Visible German Websites on Melanoma Immunotherapy: A Web-Based Analysis

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Due to recent advances in minimally invasive surgery, radiotherapy, chemotherapy, concurrent radiochemotherapy, biological therapy and other comprehensive treatment modalities, patient survival times have increased and patient quality of life has improved (5). However, the high rates of relapse and metastasis of laryngeal cancer in addition to chemotherapy resistance lead to poor treatment outcomes (6,7). Thus, to investigate and develop novel targeted treatments for cancer, laryngeal cancer must be investigated from a novel perspective.…”

Section: Introductionmentioning

confidence: 99%

Xanthohumol inhibits proliferation of laryngeal squamous cell carcinoma

Wang

Yin

et al. 2016

Oncology Letters

View full text Add to dashboard Cite

Abstract. Xanthohumol is a flavonoid compound that exhibits antioxidant and anticancer effects, and is used to treat atherosclerosis. The aim of the present study was to investigate the effect of xanthohumol on the cell proliferation of laryngeal squamous cell carcinoma and to understand the mechanism of its action. The effects of xanthohumol on the cell viability and apoptosis rate of laryngeal squamous cell carcinoma SCC4 cells were assessed by Annexin V-fluorescein isothiocyanate/propidium iodide staining. In addition, the expression levels of pro-apoptotic proteins, caspase-3, caspase-8, caspase-9, poly ADP ribose polymerase (PARP) p53 and apoptosis-inducing factor (AIF), as well as anti-apoptotic markers, B-cell lymphoma 2 (Bcl-2) and myeloid cell leukemia 1 (Mcl-1), were analyzed by western blotting. The results revealed that treatment with 40 µM xanthohumol significantly inhibited the proliferation of SCC4 cells. Furthermore, xanthohumol treatment (40 µM) induced SCC4 cell apoptosis, as indicated by the significant increase in activity and expression of caspase-3, caspase-8, caspase-9, PARP, p53 and AIF. By contrast, the protein expression of Bcl-2 and Mcl-1 was significantly decreased following treatment with 40 µM xanthohumol. Taken together, the results of the present study indicated that xanthohumol mediates growth suppression and apoptosis induction, which was mediated via the suppression of Bcl-2 and Mcl-1 and activation of PARP, p53 and AIF signaling pathways. Therefore, future studies that investigate xanthohumol as a potential therapeutic agent for laryngeal squamous cell carcinoma are required.

show abstract

“…Health literacy is defined as the “degree to which individuals have the capacity to obtain, process and understand basic health information and services needed to make appropriate health decisions.” (p. 3) Low health literacy is associated with increased hospital rates and even mortality 30 and is related to the educational level of patients, which is relatively low among head and neck cancer patients . Yet, Narwani et al evaluated online available patient information for larynx cancer and demonstrated that it was written at an advanced level, similar to that of Time magazine . Indeed, also after the first evaluation of our PDA, participants recommended simplifying the PDA to make it more readable and understandable.…”

Section: Discussionmentioning

confidence: 99%

Improving decision making in larynx cancer by developing a decision aid: A mixed methods approach

et al. 2019

View full text Add to dashboard Cite

ObjectivePatients diagnosed with advanced larynx cancer face a decisional process in which they can choose between radiotherapy, chemoradiotherapy, or a total laryngectomy with adjuvant radiotherapy. Clinicians do not always agree on the best clinical treatment, making the decisional process for patients a complex problem.MethodsGuided by the International Patient Decision Aid (PDA) Standards, we followed three developmental phases for which we held semi‐structured in‐depth interviews with patients and physicians, thinking‐out‐loud sessions, and a study‐specific questionnaire. Audio‐recorded interviews were verbatim transcribed, thematically coded, and analyzed. Phase 1 consisted of an evaluation of the decisional needs and the regular counseling process; phase 2 tested the comprehensibility and usability of the PDA; and phase 3 beta tested the feasibility of the PDA.ResultsPatients and doctors agreed on the need for development of a PDA. Major revisions were conducted after phase 1 to improve the readability and replace the majority of text with video animations. Patients and physicians considered the PDA to be a major improvement to the current counseling process.ConclusionThis study describes the development of a comprehensible and easy‐to‐use online patient decision aid for advanced larynx cancer, which was found satisfactory by patients and physicians (available on http://www.treatmentchoice.info). The outcome of the interviews underscores the need for better patient counseling. The feasibility and satisfaction among newly diagnosed patients as well as doctors will need to be proven. To this end, we started a multicenter trial evaluating the PDA in clinical practice (http://ClinicalTrials.gov Identifier: NCT03292341).Level of EvidenceNA Laryngoscope, 129:2733–2739, 2019

show abstract

Readability and quality assessment of internet‐based patient education materials related to laryngeal cancer

Abstract: Our study suggests much of the laryngeal cancer information available online is of suboptimal quality and written at a level too difficult for the average adult to read comfortably.

Cited by 38 publications

References 33 publications

Exploring the Most Visible German Websites on Melanoma Immunotherapy: A Web-Based Analysis

Exploring the Most Visible German Websites on Melanoma Immunotherapy: A Web-Based Analysis

Xanthohumol inhibits proliferation of laryngeal squamous cell carcinoma

Improving decision making in larynx cancer by developing a decision aid: A mixed methods approach

Contact Info

Product

Resources

About