Reactivity of 7-Aminoindoles with Acetylacetone

Ethyl 2-[(Z)-2-(2-nitrophenyl)hydrazinylidene]propanoate

“…However, the synthesis of phenylhydrazone by the condensation of phenylhydrazine with carbonyl compounds or by condensation of o-nitroaniline diazonium with ethyl -methylacetoacetate in basic medium (Japp-Klingemann reaction) lead to two tautomeric products (Murakami et al, 1993;Wagaw et al, 1999;Lipinska et al, 1999). Based on our indole synthesis program (El Kihel et al, 2013, 2007El Ouar et al, 1995), we report in this work the isolation of the majority product of the mixture of the two tautomers.…”

Crystal structure of (Z)-ethyl 3-[2-(5-methyl-7-nitro-1H-indole-2-carbonyl)hydrazinylidene]butanoate

“…For medicinal activity, see: El Kihel et al (2007Kihel et al ( , 2013; Penning et al (1997); Dumas et al (2000). For starting materials, see: El Ouar et al (1995 Symmetry codes: (i) Àx þ 1; Ày; Àz þ 2; (ii) x; y þ 1; z þ 1; (iii) Àx þ 1; Ày; Àz þ 1.…”

“…In previous papers (El Kihel et al, 2007;2013;El Ouar et al, 1995), we have reported some reactions of 7-aminoindoles and the condensation of the 7-nitroindole-2-carbohydrazide with acetylacetone. Herein, we report the Table 2.…”

One‐Step Synthesis of Fused Chromeno[4,3‐b]pyrrolo[3,2‐h]quinolin‐7(1H)‐One Compounds and their Anticancer Activity Evaluation

“…El Ouar et al . have reported the synthesis of these molecules in modest yields by reacting ethyl‐7‐aminoindole‐2‐carboxylate with various 1,3‐diketones at 220 o C, in the presence of p ‐toluenesulfonic acid . Steve Ley and co‐workers, in their effort towards microwave assisted Leimgruber‐Batcho indole synthesis, have demonstrated diversity of their synthesis by showing formation of pyrrolo[3,2‐ h ]quinoline as one of the products .…”