Reactivity in Free Radical Telomerization

Starks, Charles M.

doi:10.1016/b978-0-12-663650-5.50006-7

Cited by 13 publications

(12 citation statements)

References 58 publications

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“…Thus, telomerization of Tris(hydroxymethyl)acrylamidomethane in a presence of this hydrophobic thiol molecule as telogen was performed in a THF/methanol mixture at 65°C under an argon atmosphere, using a,a 0 -azobis isobutyronitrile (AIBN) as radical initiator. The AIBN concentration in the reaction mixture was roughly ten times lower than the thiol molecule (called telogen) [17].…”

Section: Detergent Synthesismentioning

confidence: 96%

New tensio‐active molecules stabilize a human G protein‐coupled receptor in solution

Damian¹,

Périno²,

Polidori³

et al. 2007

FEBS Letters

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Structural characterization of membrane proteins is hampered by the instability of the isolated proteins in detergent solutions. Here, we describe a new class of phospholipid-like surfactants that stabilize the G protein-coupled receptor, BLT1. These compounds, called C(13)U(9), C(13)U(19), C(15)U(25) and C(17)U(16), were synthesized by radical polymerization of Tris(hydroxymethyl) acrylamidomethane in the presence of thioglycerol, first endowed with two hydrocarbon chains with variable lengths (13-17 carbon atoms), as transfer reagent. C(13)U(19), C(17)U(16) or C(15)U(25) significantly enhanced the stability of BLT1 in solution compared to what was obtained with common detergents. These molecules therefore represent a promising step towards the structural characterization of BLT1 and possibly other membrane proteins.

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Section: Detergent Synthesismentioning

confidence: 96%

New tensio‐active molecules stabilize a human G protein‐coupled receptor in solution

Damian¹,

Périno²,

Polidori³

et al. 2007

FEBS Letters

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“…This coupling is not possible at present for NMR, but is common practice for mass spectrometry. For just this reason we were prompted to explore the use of mass spectrometry coupled with high resolution gas chromatography (GC-MS) in the analysis of an oligomeric mixture for the study of some aspects of the polymerization mechanism Our method of investigation is not completely new: the use of quenchers for studying the structure and fate of primary radicals is reported in the literature (4), as is the study of product distribution in oligomerization (5,6). We took advantage of very efficient separation methods (capillary GC columns) and directed our research to the study of the chain transfer reaction and to the presence of chain-end effects.…”

Section: Dipartimentomentioning

confidence: 99%

“…The birth and development of radical polymerization dates back to the first half of this century and was due to the efforts of a great number of scientists who proposed a consistent explanation for most of the experimental facts known at that Our method of investigation is not completely new: the use of quenchers for studying the structure and fate of primary radicals is reported in the literature (4), as is the study of product distribution in oligomerization (5,6). We took advantage of very efficient separation methods (capillary GC columns) and directed our research to the study of the chain transfer reaction and to the presence of chain-end effects.…”

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confidence: 99%

Recent studies on radical polymerization

Farina

Silvestro

Sozzani

et al. 1991

Makromolekulare Chemie. Macromolecular Symposia

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Different aspects of radical polymerization have been investigated in the author's laboratory. 1) Radical oligomerization has been studied by GC-MS and some kinetic parameters obtained in this way (chain transfer and reinitiation constants, reactivity ratios) compared with the results of classical experiments.2 ) Star-shaped polymers have been obtained by using a series of polyfunctional chain transfer agents; the experimental results agree very well with the theoretical expectations. 3 ) A reexamination of the copolymerization equation showed that the steady-state assumption is not a necessary condition for the kinetic derivation and that all approaches are conceptually equivalent. 4 ) The structure and the 2D NMR spectra of hemiisotactic polypropylene obtained by radical inclusion polymerization are discussed.Radical polymerization is often considered as an old and obsolete subject of polymer science, no longer worthy of further attention. This statement, however, can be easily confuted.The birth and development of radical polymerization dates back to the first half of this century and was due to the efforts of a great number of scientists who proposed a consistent explanation for most of the experimental facts known at that time.Attention was directed mainly to the kinetic interpretation as this gives a quantitative (or semiquantitative) prediction of the reaction rate and molecular weight. More subtle features of the process were disregarded.Structural aspects in particular were hardly investigated due to the lack of instrumentation existing at that time.The situation, however, has chanqed v e r y much in the last few 0 1991 Hiithig & Wepf Verlag, Base1 CCC 0258-0322/91/$02.50

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“…Tri-and tetrahaloalkanes were extensively studied as telogens in redox telomerization [22][23][24]52 (very few examples of dichlorinated, 54 -56 monobrominated, 57,58 and monochlorinated 53 active telogens were reported). Among them, polychloroalkanes were the most frequently used.…”

Section: Introductionmentioning

confidence: 99%

“…Among them, and as an extension of redox telomerization of an alkene with a (poly)haloalkane, [22][23][24] leading to low molecular weight products-generally monoadducts-with a high selectivity, several authors [25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43] developed transition metal catalyzed systems to control radical polymerization of various monomers.…”

Section: Introductionmentioning

confidence: 99%