Reactive perforating collagenosis

Reactive Perforating Collagenosis

“…The role of trauma in the causation of these lesions has been stressed by all authors [1][2][3], The lesions are located mainly on the areas prone to trau ma; Koebner phenomenon has been observed in almost all the reported cases and Bovenmyer [1] was successful in reproducing lesions in a patient following trauma by a hypodermic needle.…”

“…This would suggest that these individuals are more prone to develop necrobiosis of collagen in response to trauma. Onset of lesions at an early age and occurrence of disease in more than one member in the same family [1,3] suggest a hereditary predisposition, but so far the disease has not been observed in more than one generation, and the bio chemical defect has yet to be defined.…”

“…The lesions are located mainly on the extremities and show a relationship with trauma, Koebner phenomenon having been observed in most of the cases [1,3], Bovenmyf.r [1] also observed lesions following insect bites and acne vulgaris and experimentally produced the lesions by a scratch with a hypodermic needle. Histologically, the lesions are characterized by transepidermal extrusion of altered collagen fibres.…”

Reactive Perforating Collagenosis

“…Scratches and abrasions of varied intensi ty are the most frequent causes which induce new lesions; lesions following corporal pun ishment deserves special attention [11], New eruptions caused by low temperatures dur ing winter [5,10] and by insect bites [3,4,6] did not occur in our cases. Genetic predispo sition to the disease was previously suspect ed [5,6,8].…”

“…The familial cases [5,6,11] reported in the literature, inclusive in two successive generations [8], suggest that besides the trau matism there is probably a genetic predispo sition towards the elimination of altered col lagen. Perusal of the literature demonstrated that 31 cases have been reported to date.…”