Reactive Oxygen Species Scavenging Activity of Flavone Glycosides from Melilotus neapolitana

Fiorentino, Antonio; D’Abrosca, Brigida; Pacifico, Severina; Golino, Annunziata; Mastellone, Claudio; Oriano, Palma; Monaco, Pietro

doi:10.3390/12020263

Cited by 27 publications

(13 citation statements)

References 12 publications

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“…The phenolic hydroxyl moieties may easily react with O 2 − · and ·OH, reducing the accumulation of ROS (Rice-Evans et al 1996). Second, IQ is an effective antioxidant and it may inhibit MDA formation (Fiorentino et al 2007). IQ also possesses a potential chemopreventive action against liver preneoplastic lesion development (Yokohira et al 2008).…”

Section: Discussionmentioning

confidence: 99%

In vivo antioxidative effect of isoquercitrin on cadmium-induced oxidative damage to mouse liver and kidney

Yuan

Dong

et al. 2011

Naunyn-Schmiedeberg's Arch Pharmacol

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Cadmium (Cd) is an environmental pollutant and has been found to pose a potential threat to human health. Isoquercitrin (IQ) is one of the most important flavonoids and has been demonstrated to exhibit potent antioxidant effects on plants and yeast cells. However, only few studies have investigated the antioxidative activities of reactive oxygen species (ROS) and the nitrite scavenging activities of IQ against Cd-induced oxidation in mouse. The present work was to investigate the ROS and nitrite-scavenging activities of IQ in vitro as well as its preventive effects against lipid peroxidation and protein oxidative damage in liver and kidney of mouse induced by Cd(²+) using spectrophotometry. Our results showed that IQ possesses scavenging abilities for superoxide anion, hydroxyl radical and nitrite. Such scavenging capacities increase with the concentration of IQ. Moreover, cadmium chloride (CdCl₂ (2.5 mg/kg body weight, i.p. CdCl₂) significantly inhibited the activities of superoxide dismutase and catalase and raised the levels of malondialdehyde, nitric oxide, protein carbonyl, and the coefficients of DNA-protein crosslinks in livers and/or kidneys of mice. IQ attenuated the Cd(²+)-induced biochemical alterations in the livers and/or kidneys of mice, indicating that the formation of ROS and nitrite is possibly reduced. Our work demonstrates that IQ possesses ROS and nitrite-scavenging capacities and plays a significant role in combating Cd(²+)-induced toxicity in animals.

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Section: Discussionmentioning

confidence: 99%

In vivo antioxidative effect of isoquercitrin on cadmium-induced oxidative damage to mouse liver and kidney

Yuan

Dong

et al. 2011

Naunyn-Schmiedeberg's Arch Pharmacol

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“…The concentrations of thiobarbituric acid reactive substances (TBARS) and superoxide anion have been observed to increase after vincristine treatment (30,31). Furthermore, Melilotus extract has been shown to inhibit the formation of TBARS, the prooxidant H 2 O 2 and superoxide anion in a concentration-dependent manner (32,33). Therefore, the anti-allodynic activity of theoesberiven F observed in the present study may be attributed to the antioxidative effect of Melilotus extract.…”

Section: Discussionmentioning

confidence: 99%

Anti-allodynic effect of theoesberiven F in a vincristine-induced neuropathy model

Bang

Kim

Jeong

2016

Experimental and Therapeutic Medicine

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Abstract. Allodynia is a main symptom of the peripheral neuropathy induced by vincristine treatment. Theoesberiven F, a combination of Melilotus extract and proxyphylline, is currently used for the treatment of inflammatory conditions due to its potent anti-inflammatory and analgesic properties. The anti-allodynic effect of theoesberiven F on mechanical and cold allodynia in a rat model of vincristine-induced neuropathy was investigated in the present study. Intraperitoneal vincristine injections were administered to male Sprague-Dawley rats at a dose of 0.1 mg/kg/day over 12 days (5 days of injection, a 2-day cessation and 5 days of injection). Rats that were allodynic following the vincristine injections were randomly allocated into four groups. Normal saline was injected into rats in the control group. Theoesberiven F (0.1, 0.25 and 0.5 mg/kg) was administered to rats in the three experimental groups, respectively. Mechanical and cold allodynia were measured at preadministration and at 15,30, 60, 90, 120, 150 and 180 min following the intraperitoneal administration of normal saline or theoesberiven F. The decreased paw withdrawal threshold induced by vincristine injection was increased by theoesberiven F administration. The increased withdrawal frequency to cold stimuli developed by vincristine was reduced by theoesberiven F administration. The results of this study suggest that the administration of theoesberiven F may be beneficial in reducing the mechanical and cold allodynia developed during vincristine treatment.

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“…Recently, we reported the phytochemical study and antioxidant activities of secondary metabolites isolated from edible (Cefarelli et al, 2006; and no-edible plants (Fiorentino, D'Abrosca, Pacifico, Iacovino, et al, 2006;Fiorentino, DellaGreca, et al, 2006;Fiorentino, D'Abrosca, Pacifico, Golino, et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Antioxidant evaluation of polyhydroxylated nerolidols from redroot pigweed (Amaranthus retroflexus) leaves

Pacifico¹,

D’Abrosca²,

Golino³

et al. 2008

LWT - Food Science and Technology

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Reactive Oxygen Species Scavenging Activity of Flavone Glycosides from Melilotus neapolitana

Cited by 27 publications

References 12 publications

In vivo antioxidative effect of isoquercitrin on cadmium-induced oxidative damage to mouse liver and kidney

In vivo antioxidative effect of isoquercitrin on cadmium-induced oxidative damage to mouse liver and kidney

Anti-allodynic effect of theoesberiven F in a vincristine-induced neuropathy model

Antioxidant evaluation of polyhydroxylated nerolidols from redroot pigweed (Amaranthus retroflexus) leaves

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