Reactive oxygen species (ROS) and wound healing: the functional role of ROS and emerging ROS‐modulating technologies for augmentation of the healing process

Abstract

Reactive oxygen species (ROS) play a pivotal role in the orchestration of the normal wound-healing response. They act as secondary messengers to many immunocytes and non-lymphoid cells, which are involved in the repair process, and appear to be important in coordinating the recruitment of lymphoid cells to the wound site and effective tissue repair. ROS also possess the ability to regulate the formation of blood vessels (angiogenesis) at the wound site and the optimal perfusion of blood into the wound-healing area. ROS act in the host's defence through phagocytes that induce an ROS burst onto the pathogens present in wounds, leading to their destruction, and during this period, excess ROS leakage into the surrounding environment has further bacteriostatic effects. In light of these important roles of ROS in wound healing and the continued quest for therapeutic strategies to treat wounds in general and chronic wounds, such as diabetic foot ulcers, venous and arterial leg ulcers and pressure ulcers in particular, the manipulation of ROS represents a promising avenue for improving wound-healing responses when they are stalled. This article presents a review of the evidence supporting the critical role of ROS in wound healing and infection control at the wound site, and some of the new emerging concepts associated with ROS modulation and its potential in improving wound healing are discussed.

Prevention of bacterial colonization on non-thermal atmospheric plasma treated surgical sutures for control and prevention of surgical site infections

“…The wound area, determined for various types of the 7-minute NTAP-treated sutures, didn’t show any statistically significant difference. As previously indicated in the literature, reactive oxygen species (ROS) generated with NTAP act as a signal molecule and accelerate the wound closure [52–55]. In another study, Murrell et al reported that ROS significantly promotes the migration and proliferation of human fibroblasts [56].…”

Multifunctional Thioredoxin-Like Protein from the Gastrointestinal Parasitic NematodesStrongyloides rattiandTrichuris suisAffects Mucosal Homeostasis

“…Trx may be important for redox control at wound margins, since much ROS emergence was proven there [91, 92]. ROS as second messenger ameliorates wound healing processes [93]. Therefore, among others, it serves the migration of cells and closure of wounds.…”

In Vitro Evaluation of the Antioxidant Activity and Wound Healing Properties of Jaboticaba (Plinia peruviana) Fruit Peel Hydroalcoholic Extract

“…Angiogenesis is triggered and leads to the formation of granulation tissue, which is important to support the nutrients and oxygen supply in injured tissue [4–6]. In this tissue, fibroblasts become myofibroblasts which synthesize and deposit extracellular matrix (ECM) compounds, especially collagen.…”