Reactive oxygen species generated by titanium oxide nanoparticles stimulate the hemoglobin denaturation and cytotoxicity against human lymphocyte cell

Aliakbari, Fakhteh; Hosseinali, Sara Haji; Sarokhalil, Ziba Khalili; Shahpasand, Koorosh; Saboury, Ali Akbar; Akhtari, Keivan; Falahati, Mojtaba

doi:10.1080/07391102.2019.1568305

Cited by 14 publications

(7 citation statements)

References 15 publications

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“…A recent review in vitro and in vivo animal studies concluded that TiO 2 nanoparticles not only, accumulate in the tissues of mammals and other vertebrates, but that they also have a very limited elimination rate ( Kononenko et al, 2019;Aliakbari et al, 2019;Dorier et al, 2015;Kruger et al, 2014;Gerloff et al, 2012;Cho et al, 2013;Shi et al, 2013;Jovanović 2015;Wang et al, 2007;Powell et al, 2000;Wang et al, 2007;Trouiller et al, 2009;Valant et al, 2011;Duan et al, 2010;Nogueira et al, 2012;Bu et al, 2010;Tada-Oikawa et al, 2016;Song et al, 2013;Brun et al, 2014;Chalew et al, 2013;Gerloff et al, 2009;Monopoli et al, 2011;Lesniak et al, 2013;Wang et al, 2013). Nevertheless, the results are conflicting, some of them have reported little accumulation or toxicity (Monopoli et al, 2011) of ingested TiO 2 nanoparticles.…”

Section: Titanium Nanoparticlesmentioning

confidence: 99%

Recent advances and challenges on applications of nanotechnology in food packaging. A literature review

Enescu

Cerqueira

Fuciños

et al. 2019

Food and Chemical Toxicology

115

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Nanotechnology applied to food and beverage packaging has created enormous interest in recent years, but in the same time there are many controversial issues surrounding nanotechnology and food. The benefits of engineered nanoparticles (ENPs) in food-contact applications are accompanied by safety concerns due to gaps in understanding the toxicology. In case of incorporation in food contact polymers, the first step to consumer exposure is the transfer of ENPs from the polymer to the food. Hence, to improve understanding of risk and benefit, the key questions are whether nanoparticles can be released from food contact polymers and under which conditions. This review has two main goals. Firstly, it will be presented the current advancements in the application of ENPs in food and beverage packaging sector to grant active and intelligent properties. A particular focus will be placed on current demands in terms of risk assessment strategies associated with the use ENPs in food contact materials (FCMs), i.e. upto-date migration / cytotoxicity studies of ENPs which are partly contradictory. Secondly, the review provide an extensive analysis of present market dynamics on ENPs in food/beverage packaging moving beyond concept to current industrial applications.

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Section: Titanium Nanoparticlesmentioning

confidence: 99%

Recent advances and challenges on applications of nanotechnology in food packaging. A literature review

Enescu

Cerqueira

Fuciños

et al. 2019

Food and Chemical Toxicology

115

View full text Add to dashboard Cite

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“…Extensive use of TiO 2 NPs reasonably raises significant concerns due to their potential nanotoxicity, induced by oxidative stress, which is influenced by ROS (Reactive Oxygen Species) formation on the surface of TiO 2 NPs in the presence of UV light [ 9 , 10 , 11 , 12 ]. After the penetration of TiO 2 NPs into the human body, inflammation, cytotoxicity, genotoxicity, immunotoxicity, and neurotoxicity may occur.…”

Section: Introductionmentioning

confidence: 99%

Influence of Titanium Dioxide Nanoparticles on Human Health and the Environment

2021

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Nanotechnology has enabled tremendous breakthroughs in the development of materials and, nowadays, is well established in various economic fields. Among the various nanomaterials, TiO2 nanoparticles (NPs) occupy a special position, as they are distinguished by their high availability, high photocatalytic activity, and favorable price, which make them useful in the production of paints, plastics, paper, cosmetics, food, furniture, etc. In textiles, TiO2 NPs are widely used in chemical finishing processes to impart various protective functional properties to the fibers for the production of high-tech textile products with high added value. Such applications contribute to the overall consumption of TiO2 NPs, which gives rise to reasonable considerations about the impact of TiO2 NPs on human health and the environment, and debates regarding whether the extent of the benefits gained from the use of TiO2 NPs justifies the potential risks. In this study, different TiO2 NP exposure modes are discussed, and their toxicity mechanisms—evaluated in various in vitro and in vivo studies—are briefly described, considering the molecular interactions with human health and the environment. In addition, in the conclusion of this study, the toxicity and biocompatibility of TiO2 NPs are discussed, along with relevant risk management strategies.

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“…However, this reaction can increase the fluorescence intensity of the DCF product and give false-positive results [ 126 , 127 , 128 ]. In the case of the measurement of ROS production in tested nanomaterials, the form of DCFH-DA has been mostly used in ZnO 2 NMs [ 33 , 129 , 130 , 131 , 132 ] and TiO 2 NMs [ 133 , 134 , 135 , 136 ].…”

Section: Reactive Oxygen Speciesmentioning

confidence: 99%

Detection of Oxidative Stress Induced by Nanomaterials in Cells—The Roles of Reactive Oxygen Species and Glutathione

Čapek

Roušar

2021

Molecules

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The potential of nanomaterials use is huge, especially in fields such as medicine or industry. Due to widespread use of nanomaterials, their cytotoxicity and involvement in cellular pathways ought to be evaluated in detail. Nanomaterials can induce the production of a number of substances in cells, including reactive oxygen species (ROS), participating in physiological and pathological cellular processes. These highly reactive substances include: superoxide, singlet oxygen, hydroxyl radical, and hydrogen peroxide. For overall assessment, there are a number of fluorescent probes in particular that are very specific and selective for given ROS. In addition, due to the involvement of ROS in a number of cellular signaling pathways, understanding the principle of ROS production induced by nanomaterials is very important. For defense, the cells have a number of reparative and especially antioxidant mechanisms. One of the most potent antioxidants is a tripeptide glutathione. Thus, the glutathione depletion can be a characteristic manifestation of harmful effects caused by the prooxidative-acting of nanomaterials in cells. For these reasons, here we would like to provide a review on the current knowledge of ROS-mediated cellular nanotoxicity manifesting as glutathione depletion, including an overview of approaches for the detection of ROS levels in cells.

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Reactive oxygen species generated by titanium oxide nanoparticles stimulate the hemoglobin denaturation and cytotoxicity against human lymphocyte cell

Cited by 14 publications

References 15 publications

Recent advances and challenges on applications of nanotechnology in food packaging. A literature review

Recent advances and challenges on applications of nanotechnology in food packaging. A literature review

Influence of Titanium Dioxide Nanoparticles on Human Health and the Environment

Detection of Oxidative Stress Induced by Nanomaterials in Cells—The Roles of Reactive Oxygen Species and Glutathione

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