Reactive Oxygen Species, Cancer and Anti-Cancer Therapies

Trends in the Evaluation of Lipid Peroxidation Processes

“…All these structural and functional changes have direct clinical consequences, leading to the acceleration of the general aging process, but also to some pathological phenomena, associated with the increase of the capillary permeability, impairment of the blood cell function, etc. ROS lesions are frequently associated with aging [Dröge & Schipper, 2007;Griffiths et al, 2011], atheroclerosis [Hulsmans & Holvoet, 2010], cardio-vascular disease [Dikalov & Nazarewicz, 2012;Puddu et al, 2009], type I or type II diabetes mellitus [Cai et al, 2004], autoimmune disorders, neurodegenerative disorders such as Parkinson [Yoritaka et al, 1996] or Alzheimer's disease [Sayre et al, 1997;Takeda et al, 2000], inflammatory diseases such as reumatoid arthritis [Griffiths et al, 2011] or different types of cancers [Lenaz, 2012;Li et al, 2009;Manda et al, 2009].…”

Indicators of oxidative and nitrosative stress and activity of enzymes of nitric oxide metabolism in rats treated with 4-thiazolidinone derivatives possessing antineoplastic activity

“…The mammalian cells produce free radi cal metabolites of oxygen and nitrogen that might be involved in transferring the regulatory signals in targeted cells [1,4,6]. The relevant signaling molecules affect cellular metabolism and play a key role in non-specific immune defense against the pathogenic factors, including those appearing at cancer development [5][6][7].…”

“…New antineoplastic strategy based on differential induction of FROdependent mechanisms in normal and tumor cells has been proposed [1,11,13]. It should be noted that the use of most existing therapies in oncology is accompanied by the development of harmful effects of FRO on the cells of normal tissues and organs [1,5,6,[11][12][13]. These negative side effects are mostly caused by ROS and RNS that significantly limits the applied dosage of appropriate anticancer drugs [1,5,6,12,14].…”

“…It should be noted that the use of most existing therapies in oncology is accompanied by the development of harmful effects of FRO on the cells of normal tissues and organs [1,5,6,[11][12][13]. These negative side effects are mostly caused by ROS and RNS that significantly limits the applied dosage of appropriate anticancer drugs [1,5,6,12,14]. Therefore, the oxidation-reduction balance in cells is an important biochemical target at the elimination of tumor cells.…”

DNA damage and base excision repair : an important role during zebrafish embryogenesis

“…Cellular redox status, reflected in the levels of glutathione and thioredoxin/thioredoxin reductase, is usually construed as the relative ability to make or break disulfide bonds (Manda, Nechifor, and Neagu 2009). Despite the ongoing production of ROS and resultant oxidative damage to DNA, the oxidative state of DNA is overlooked.…”