Reactive oxygen species, apoptosis and cancer

Stojnev, Slavica; Ristic-Petrovic, Ana; Veličković, Ljubinka Janković

doi:10.2298/vsp1307675s

Cited by 24 publications

(12 citation statements)

References 41 publications

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“…(3) Mitochondrial dysfunction, which may promote cell death. It has been shown that ROS can initiate the apoptotic cascade via increasing the permeability of the mitochondrial membrane [21]. (4) Phagosome maturation, which involves the fusion between phagosomes and intracellular organelles and has been implicated in the elimination of cells that have undergone apoptosis [31].…”

Section: Discussionmentioning

confidence: 99%

Proteomics-Metabolomics Combined Approach Identifies Peroxidasin as a Protector against Metabolic and Oxidative Stress in Prostate Cancer

Dougan

Hawsawi

Burton

et al. 2019

IJMS

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: Peroxidasin (PXDN), a human homolog of Drosophila PXDN, belongs to the family of heme peroxidases and has been found to promote oxidative stress in cardiovascular tissue, however, its role in prostate cancer has not been previously elucidated. We hypothesized that PXDN promotes prostate cancer progression via regulation of metabolic and oxidative stress pathways. We analyzed PXDN expression in prostate tissue by immunohistochemistry and found increased PXDN expression with prostate cancer progression as compared to normal tissue or cells. PXDN knockdown followed by proteomic analysis revealed an increase in oxidative stress, mitochondrial dysfunction and gluconeogenesis pathways. Additionally, Liquid Chromatography with tandem mass spectrometry (LC-MS/MS)-based metabolomics confirmed that PXDN knockdown induced global reprogramming associated with increased oxidative stress and decreased nucleotide biosynthesis. We further demonstrated that PXDN knockdown led to an increase in reactive oxygen species (ROS) associated with decreased cell viability and increased apoptosis. Finally, PXDN knockdown decreased colony formation on soft agar. Overall, the data suggest that PXDN promotes progression of prostate cancer by regulating the metabolome, more specifically, by inhibiting oxidative stress leading to decreased apoptosis. Therefore, PXDN may be a biomarker associated with prostate cancer and a potential therapeutic target.

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Section: Discussionmentioning

confidence: 99%

Proteomics-Metabolomics Combined Approach Identifies Peroxidasin as a Protector against Metabolic and Oxidative Stress in Prostate Cancer

Dougan

Hawsawi

Burton

et al. 2019

IJMS

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“…Increased fluxes of free radicals are associated with biomolecule damage and play a key role in the initiation of various complications such as cardiovascular diseases 15 and cancer. 16 The final products of lipid peroxidation have an important role in activating oncogenes by interfering with the balance between the antioxidant/oxidative stress system and through expression of some genes that contribute to cancer initiation and progression. 17 We found that the antioxidant activities of PON1 and ARE were significantly lower in MM patients compared to the control group.…”

Section: Discussionmentioning

confidence: 99%

Serum 8-isoprostane levels and paraoxonase 1 activity in patients with stage I multiple myeloma

2016

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“…Reactive species have been implicated in different stages of carcinogenesis, including initiation, promotion and progression . Reactive species are important inducers of cancer by inducing DNA mutations, activating oncogenes and inhibiting tumor suppressor genes . In several animal experiments, an increase in antioxidant capacity has been suggested to lead to better cancer outcomes .…”

Section: The Dual Roles Of Reactive Species In Diseasementioning

confidence: 99%

Physiological regulation of reactive oxygen species in organisms based on their physicochemical properties

Huang

2019

Acta Physiologica

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Oxidative stress is recognized as free radical dyshomeostasis, which has damaging effects on proteins, lipids and DNA. However, during cell differentiation and proliferation and other normal physiological processes, free radicals play a pivotal role in message transmission and are considered important messengers. Organisms maintain free radical homeostasis through a sophisticated regulatory system in which these "2faced" molecules play appropriate roles under physiological and pathological conditions. Reactive oxygen species (ROS), including a large number of free radicals, act as redox signalling molecules in essential cellular signalling pathways, including cell differentiation and proliferation. However, excessive ROS levels can induce oxidative stress, which is an important risk factor for diabetes, cancer and cardiovascular disease. An overall comprehensive understanding of ROS is beneficial for understanding the pathogenesis of certain diseases and finding new therapeutic treatments.This review primarily focuses on ROS cellular localization, sources, chemistry and molecular targets to determine how to distinguish between the roles of ROS as messengers and in oxidative stress. K E Y W O R D Shomeostasis, oxidative stress, reactive oxygen, redox signalling, signalling pathways 2 of 16 | HUANG ANd LI for the development of new therapeutic strategies for cancer and cardiovascular disease. | SOURCES AND PHYSICOCHEMICAL PROPERTIES OF ROS | ROS sourcessecond messengers, what are the corresponding acceptors for these special ROS? To better recognize ROS, a new tool that can monitor changes in ROS levels and position in real time must be developed. Determining how to utilize the characteristics of ROS to treat diseases, such as cardiovascular disease, diabetes, autoimmune diseases, cancer and Alzheimer's diseases, is worth further exploration.

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Reactive oxygen species, apoptosis and cancer

Abstract: Projekat Ministarstva nauke Republike Srbije, br. 17509

Cited by 24 publications

References 41 publications

Proteomics-Metabolomics Combined Approach Identifies Peroxidasin as a Protector against Metabolic and Oxidative Stress in Prostate Cancer

Proteomics-Metabolomics Combined Approach Identifies Peroxidasin as a Protector against Metabolic and Oxidative Stress in Prostate Cancer

Serum 8-isoprostane levels and paraoxonase 1 activity in patients with stage I multiple myeloma

Physiological regulation of reactive oxygen species in organisms based on their physicochemical properties

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