Reactive metal boride nanoparticles trap lipopolysaccharide and peptidoglycan for bacteria-infected wound healing

Meng, Yanlong; Chen, Lijie; Chen, Yang; Shi, Jieyun; Zhang, Zheng; Wang, Yiwen; Wu, Fan; Jiang, Xingwu; Yang, Wei; Zhang, Li; Wang, Chaochao; Meng, Xianfu; Wu, Yelin; Bu, Wenbo

doi:10.1038/s41467-022-35050-6

Cited by 68 publications

(38 citation statements)

References 53 publications

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“…By HSL conversion of the response color of 1–15 mmol/L, the color phase angle of each color was obtained, and its angle value was linearly fit, yielding R 2 = 0.96707 ( Figure 9 c), which already includes the human blood glucose concentration range (3.9–6.1 mmol/L), meeting the needs for simple testing of human blood glucose. Today, new kinds of polymers [ 80 , 81 , 89 ], organic and inorganic nanoparticles [ 90 , 91 ], and novel strategies for biomedical applications [ 92 , 93 , 94 , 95 , 96 , 97 ] are continuously reported. These achievements can be borrowed into the design and development of electrospun nanofibers, and thus promote new kinds of sensors and biomedical devices.…”

Section: Resultsmentioning

confidence: 99%

A Sequential Electrospinning of a Coaxial and Blending Process for Creating Double-Layer Hybrid Films to Sense Glucose

Yang

Kang

et al. 2023

Sensors

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This study presents a glucose biosensor based on electrospun core–sheath nanofibers. Two types of film were fabricated using different electrospinning procedures. Film F1 was composed solely of core–sheath nanofibers fabricated using a modified coaxial electrospinning process. Film F2 was a double-layer hybrid film fabricated through a sequential electrospinning and blending process. The bottom layer of F2 comprised core–sheath nanofibers fabricated using a modified process, in which pure polymethacrylate type A (Eudragit L100) was used as the core section and water-soluble lignin (WSL) and phenol were loaded as the sheath section. The top layer of F2 contained glucose oxidase (GOx) and gold nanoparticles, which were distributed throughout the polyvinylpyrrolidone K90 (PVP K90) nanofibers through a single-fluid blending electrospinning process. The study investigated the sequential electrospinning process in detail. The experimental results demonstrated that the F2 hybrid film had a higher degradation efficiency of β-D-glucose than F1, reaching a maximum of over 70% after 12 h within the concentration range of 10–40 mmol/L. The hybrid film F2 is used for colorimetric sensing of β-D-glucose in the range of 1–15 mmol/L. The solution exhibited a color that deepened gradually with an increase in β-D-glucose concentration. Electrospinning is flexible in creating structures for bio-cascade reactions, and the double-layer hybrid film can provide a simple template for developing other sensing nanomaterials.

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Section: Resultsmentioning

confidence: 99%

A Sequential Electrospinning of a Coaxial and Blending Process for Creating Double-Layer Hybrid Films to Sense Glucose

Yang

Kang

et al. 2023

Sensors

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“…Electrospun porous nanofibers have become a research hotspot, so with the progress and development of electrospinning technology and the unremitting efforts of scientists and researchers, more excellent performances of electrospun porous nanofibers can be developed. The expansion of their applications can be further strengthened along with the fast developments in modern science and technology, such as encapsulating new functional ingredients [ 182 , 183 , 184 ] and additives [ 185 , 186 ], exploring new types of filament-forming polymeric matrices [ 187 , 188 ], being introduced to popular life-improving applications [ 189 , 190 , 191 , 192 , 193 , 194 ], taking advantage of new strategies of synthesizing materials [ 195 , 196 ], and drawing support from traditional techniques for production on a large scale [ 197 , 198 ].…”

Section: Discussionmentioning

confidence: 99%

Recent Progress of the Preparation and Application of Electrospun Porous Nanofibers

Wang

Cao

et al. 2023

Polymers

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Electrospun porous nanofibers have gained a lot of interest recently in various fields because of their adjustable porous structure, high specific surface area, and large number of active sites, which can further enhance the performance of materials. This paper provides an overview of the common polymers, preparation, and applications of electrospun porous nanofibers. Firstly, the polymers commonly used to construct porous structures and the main pore-forming methods in porous nanofibers by electrospinning, namely the template method and phase separation method, are introduced. Secondly, recent applications of electrospun porous nanofibers in air purification, water treatment, energy storage, biomedicine, food packaging, sensor, sound and wave absorption, flame retardant, and heat insulation are reviewed. Finally, the challenges and possible research directions for the future study of electrospun porous nanofibers are discussed.

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“…As an interdisciplinary field, drug delivery sources information mainly from three areas, the knowledge of pharmacokinetics and the pharmacology of drugs in vivo ( Niu et al, 2021a ; Wang et al, 2022 ; Meng et al, 2022 ; Tang et al, 2022 ; Wang and Feng, 2022 ; Wu et al, 2022 ), new types of pharmaceutical excipients for carrying the drug molecules to the lesion locations ( Murugesan and Raman, 2021 ; Li C. F. et al, 2022 ; Wang L. et al, 2022 ; Zhu et al, 2022 ; Wang et al, 2023 ; Kostka et al, 2023 ), and new pharmaceutical techniques and related strategies, which are often introduced from other disciplines ( Chen et al, 2022 ; Xie et al, 2022 ; Song et al, 2023a ; Wang et al, 2023 ; Chen et al, 2023 ; Huang and Feng, 2023 ). During the past several decades, the effective combination of these three aspects has continuously updated the commercial drug dosage forms for a more efficient, safer, and more convenient drug administration process ( Fatema et al, 2022 ; Hopkins et al, 2022 ; Shen et al, 2022 ; Zhao et al, 2023 ).…”

Section: Introductionmentioning

confidence: 99%

Fast and convenient delivery of fluidextracts liquorice through electrospun core-shell nanohybrids

Liu

Dai

et al. 2023

Front. Bioeng. Biotechnol.

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Introduction: As an interdisciplinary field, drug delivery relies on the developments of modern science and technology. Correspondingly, how to upgrade the traditional dosage forms for a more efficacious, safer, and convenient drug delivery poses a continuous challenge to researchers.Methods, results and discussion: In this study, a proof-of-concept demonstration was conducted to convert a popular traditional liquid dosage form (a commercial oral compound solution prepared from an intermediate licorice fluidextract) into a solid dosage form. The oral commercial solution was successfully encapsulated into the core–shell nanohybrids, and the ethanol in the oral solution was removed. The SEM and TEM evaluations showed that the prepared nanofibers had linear morphologies without any discerned spindles or beads and an obvious core–shell nanostructure. The FTIR and XRD results verified that the active ingredients in the commercial solution were compatible with the polymeric matrices and were presented in the core section in an amorphous state. Three different types of methods were developed, and the fast dissolution of the electrospun core–shell nanofibers was verified.Conclusion: Coaxial electrospinning can act as a nano pharmaceutical technique to upgrade the traditional oral solution into fast-dissolving solid drug delivery films to retain the advantages of the liquid dosage forms and the solid dosage forms.

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Reactive metal boride nanoparticles trap lipopolysaccharide and peptidoglycan for bacteria-infected wound healing

Cited by 68 publications

References 53 publications

A Sequential Electrospinning of a Coaxial and Blending Process for Creating Double-Layer Hybrid Films to Sense Glucose

A Sequential Electrospinning of a Coaxial and Blending Process for Creating Double-Layer Hybrid Films to Sense Glucose

Recent Progress of the Preparation and Application of Electrospun Porous Nanofibers

Fast and convenient delivery of fluidextracts liquorice through electrospun core-shell nanohybrids

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